Automated description from the Alliance of Genome Resources (Release 3.1.1)
Predicted to have ankyrin binding activity; protein N-terminus binding activity; and structural molecule activity. Predicted to be involved in several processes, including hemidesmosome assembly; intermediate filament cytoskeleton organization; and response to nutrient. Localizes to brush border and contractile fiber. Predicted to colocalize with intermediate filament. Is expressed in retina and skin. Used to study epidermolysis bullosa simplex Ogna type and epidermolysis bullosa simplex with muscular dystrophy. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2Q; epidermolysis bullosa simplex; epidermolysis bullosa simplex Ogna type; and epidermolysis bullosa simplex with muscular dystrophy. Orthologous to human PLEC (plectin).