Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and DNA binding activity. Involved in negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including DNA methylation; cellular response to amino acid stimulus; and regulation of gene expression. Located in chromosome, centromeric region; heterochromatin; and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system. Used to study immunodeficiency-centromeric instability-facial anomalies syndrome 1. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune disease (multiple); carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).