Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates and DNA binding activity. Involved in several processes, including DNA methylation; cellular response to amino acid stimulus; and regulation of gene expression. Localizes to chromosome, centromeric region and nuclear heterochromatin. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and hemolymphoid system. Used to study immunodeficiency-centromeric instability-facial anomalies syndrome 1. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune thrombocytopenic purpura; carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and rheumatoid arthritis. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).