Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits ligase activity. Involved in several processes, including cellular protein metabolic process; positive regulation of T cell anergy; and regulation of protein metabolic process. Localizes to several cellular components, including cell cortex; cytoplasmic vesicle; and nucleus. Predicted to colocalize with early endosome. Is expressed in several structures, including central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human ITCH (itchy E3 ubiquitin protein ligase).