Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Fzd1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 27, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Fzd1
  • participates in the following biological processes:
    • cell-cell signaling ^[4]
    • epithelial cell differentiation ^[4]
    • negative regulation of BMP signaling pathway ^[5]
    • negative regulation of canonical Wnt receptor signaling pathway ^[1]
    • negative regulation of catenin import into nucleus ^[5]
• Researchers have inferred, based on physical interactions, that the gene product of Fzd1
  • performs the following molecular functions:
    • Wnt-protein binding ^[6]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Fzd1
  • participates in the following biological processes:
    • canonical Wnt receptor signaling pathway ^[3]
    • negative regulation of transcription, DNA-dependent ^[2]
    • positive regulation of protein phosphorylation ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Fzd1
  • participates in the following biological processes:
    • epithelial cell differentiation based on interactions with Barx1 ^[4]
    • hard palate development based on interactions with Fzd2 ^[7]
    • membranous septum morphogenesis based on interactions with Fzd2, Vangl2 ^[7]
    • muscular septum morphogenesis based on interactions with Fzd2, Vangl2 ^[7]
    • outflow tract morphogenesis based on interactions with Fzd2 ^[7]
    • planar cell polarity pathway involved in neural tube closure based on interactions with Fzd2, Vangl2 ^[7]
    • ventricular septum morphogenesis based on interactions with Fzd2 ^[7]
    • Wnt receptor signaling pathway based on interactions with Fzd10, Lrp5, Wnt7a ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Fzd1:
  • participates in the following biological processes:
    • autocrine signaling
    • axonogenesis
    • brain development
    • canonical Wnt receptor signaling pathway
    • canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation
    • canonical Wnt receptor signaling pathway involved in osteoblast differentiation
    • cell-cell signaling
    • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
    • gonad development
    • lung alveolus development
    • positive regulation of sequence-specific DNA binding transcription factor activity
    • positive regulation of transcription, DNA-dependent
    • regulation of transcription from RNA polymerase II promoter
    • response to drug
    • vasculature development
    • Wnt receptor signaling pathway
    • Wnt receptor signaling pathway, calcium modulating pathway
  • performs the following molecular functions:
    • PDZ domain binding
    • protein heterodimerization activity
    • protein homodimerization activity
    • receptor binding
    • Wnt-activated receptor activity
    • Wnt-protein binding
  • is located in the following cellular components:
    • apical part of cell
    • cell surface
    • cytoplasm
    • neuron projection
    • neuron projection membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Fzd1 encodes a protein or proteins that contain the following InterPro domains: Frizzled domain, Frizzled protein, Frizzled-1, Frizzled/secreted frizzled-related protein, GPCR, family 2-like, indicating that the gene product:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
  • performs the following molecular functions:
    • transmembrane signaling receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Fzd1 indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • multicellular organismal development
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Beigneux AP et al. (2004) ATP-citrate lyase deficiency in the mouse. J Biol Chem, 279:9557-64. (PubMed:14662765)
2. Borello U et al. (2006) The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development, 133:3723-32. (PubMed:16936075)
3. Gonzalez-Sancho JM et al. (2004) Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin. Mol Cell Biol, 24:4757-68. (PubMed:15143170)
4. Kim BM et al. (2005) The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling. Dev Cell, 8:611-22. (PubMed:15809042)
5. Roman-Roman S et al. (2004) Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. J Biol Chem, 279:5725-33. (PubMed:14627707)
6. Wang Z et al. (2005) Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5. Mol Cell Biol, 25:5022-30. (PubMed:15923619)
7. Yu H et al. (2010) Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development, 137:3707-17. (PubMed:20940229)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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