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Gene Ontology Classifications
Symbol
Name
ID
Per2
period circadian clock 2
MGI:1195265

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GO curators for mouse genes have assigned the following annotations to the gene product of Per2. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
References
  1. Dudley CA et al. (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science, 301:379-83. (PubMed:12843397)
  2. Jin X et al. (1999) A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell, 96:57-68. (PubMed:9989497)
  3. Padmanabhan K et al. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science, 337:599-602. (PubMed:22767893)
  4. Sakakida Y et al. (2005) Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. J Biol Chem, 280:13272-8. (PubMed:15689618)
  5. Zylka MJ et al. (1998) Molecular analysis of mammalian timeless. Neuron, 21:1115-22. (PubMed:9856466)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory