Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Per2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Per2
  • participates in the following biological processes:
    • circadian rhythm ^[3]
    • negative regulation of transcription from RNA polymerase II promoter ^[5]
  • is located in the following cellular components:
    • cytoplasm ^[9]
    • nucleus ^[8]
• The gene product of Per2 has been shown to bind to the gene products of Arntl, Clock, Cry2, Csnk1d, Csnk1e, Ddx5, Dhx9, Ncbp1, Setx, Timeless. ^{[1, 2, 4, 6, 7, 8, 10]} Researchers have inferred, based on physical interactions, that the gene product of Per2
  • performs the following molecular functions:
  • is located in the following cellular components:
    • nucleus ^[9]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Per2:
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • protein binding transcription factor activity
  • is located in the following cellular components:
    • nucleus

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Summary text based on GO annotations supported by structural data

• Per2 encodes a protein or proteins that contain the following InterPro domains: PAC motif, PAS domain, PAS fold-3, Period circadian-like, C-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • signal transduction
  • performs the following molecular functions:
    • signal transducer activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Per2 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • rhythmic process
    • transcription, DNA-dependent

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References

1. Asher G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell, 134:317-28. (PubMed:18662546)
2. Asher G et al. (2010) Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell, 142:943-53. (PubMed:20832105)
3. Dudley CA et al. (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science, 301:379-83. (PubMed:12843397)
4. Etchegaray JP et al. (2009) Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol, 29:3853-66. (PubMed:19414593)
5. Jin X et al. (1999) A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell, 96:57-68. (PubMed:9989497)
6. Langmesser S et al. (2008) Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol, 9:41. (PubMed:18430226)
7. Ozber N et al. (2010) Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol, 11:69. (PubMed:20840750)
8. Padmanabhan K et al. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science, 337:599-602. (PubMed:22767893)
9. Sakakida Y et al. (2005) Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. J Biol Chem, 280:13272-8. (PubMed:15689618)
10. Sangoram AM et al. (1998) Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron, 21:1101-13. (PubMed:9856465)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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