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Gene Ontology Classifications
period circadian clock 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Per2. (This text reflects annotations as of Thursday, January 16, 2014.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Asher G et al. (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell, 134:317-28. (PubMed:18662546)
  2. Asher G et al. (2010) Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell, 142:943-53. (PubMed:20832105)
  3. Dudley CA et al. (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science, 301:379-83. (PubMed:12843397)
  4. Etchegaray JP et al. (2009) Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol, 29:3853-66. (PubMed:19414593)
  5. Jin X et al. (1999) A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Cell, 96:57-68. (PubMed:9989497)
  6. Langmesser S et al. (2008) Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol Biol, 9:41. (PubMed:18430226)
  7. Ozber N et al. (2010) Identification of two amino acids in the C-terminal domain of mouse CRY2 essential for PER2 interaction. BMC Mol Biol, 11:69. (PubMed:20840750)
  8. Padmanabhan K et al. (2012) Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science, 337:599-602. (PubMed:22767893)
  9. Sakakida Y et al. (2005) Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. J Biol Chem, 280:13272-8. (PubMed:15689618)
  10. Sangoram AM et al. (1998) Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription. Neuron, 21:1101-13. (PubMed:9856465)
  11. Schneider K et al. (2012) CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions. EMBO Rep, 13:1138-44. (PubMed:23079727)
  12. Wallach T et al. (2013) Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. PLoS Genet, 9:e1003398. (PubMed:23555304)
  13. Yoo SH et al. (2013) Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm. Cell, 152:1091-105. (PubMed:23452855)
  14. Zylka MJ et al. (1998) Molecular analysis of mammalian timeless. Neuron, 21:1115-22. (PubMed:9856466)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.17
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