Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nrp2. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nrp2
  • participates in the following biological processes:
    • semaphorin-plexin signaling pathway ^[3]
  • performs the following molecular functions:
    • semaphorin receptor activity ^[3]
  • is located in the following cellular components:
    • axon ^[8]
• The gene product of Nrp2 has been shown to bind to the gene products of Plxna1, Sema3c. ^{[3, 7]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nrp2
  • participates in the following biological processes:
    • axon extension involved in axon guidance ^[5]
    • axon guidance ^[6]
    • gonadotrophin-releasing hormone neuronal migration to the hypothalamus ^[1]
    • negative chemotaxis ^[6]
    • nerve development ^[5]
    • neural crest cell migration ^[2]
    • neuron migration ^[1]
    • semaphorin-plexin signaling pathway involved in neuron projection guidance ^[5]
    • sympathetic ganglion development ^[5]
    • sympathetic neuron projection extension ^[5]
    • sympathetic neuron projection guidance ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Nrp2
  • participates in the following biological processes:
    • heart development based on interactions with Nrp1 ^[4]
    • negative chemotaxis based on interactions with Sema3f ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Nrp2
  • is located in the following cellular components:
    • plasma membrane ^[3]

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Summary text based on GO annotations supported by structural data

• Nrp2 encodes a protein or proteins that contain the following InterPro domains: Coagulation factor 5/8 C-terminal type domain, Concanavalin A-like lectin/glucanases superfamily, CUB domain, Galactose-binding domain-like, MAM domain, Neuropilin, Neuropilin-1, C-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • angiogenesis
    • cell adhesion
    • vascular endothelial growth factor signaling pathway
  • performs the following molecular functions:
    • vascular endothelial growth factor-activated receptor activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nrp2 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
  • performs the following molecular functions:
    • heparin binding
    • metal ion binding
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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References

1. Cariboni A et al. (2011) Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Hum Mol Genet, 20:336-44. (PubMed:21059704)
2. Gammill LS et al. (2006) Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling. Development, 133:99-106. (PubMed:16319111)
3. Gitler AD et al. (2004) PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell, 7:107-16. (PubMed:15239958)
4. Gu C et al. (2003) Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell, 5:45-57. (PubMed:12852851)
5. Maden CH et al. (2012) NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev Biol, 369:277-85. (PubMed:22790009)
6. Suto F et al. (2005) Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J Neurosci, 25:3628-37. (PubMed:15814794)
7. Takahashi T et al. (1999) Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell, 99:59-69. (PubMed:10520994)
8. Yoshihara S et al. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development, 132:751-62. (PubMed:15677725)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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