Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cpt1a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cpt1a
  • is located in the following cellular components:
    • mitochondrial inner membrane ^[1]
    • mitochondrion ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cpt1a:
  • participates in the following biological processes:
    • carnitine metabolic process
    • eating behavior
    • glucose metabolic process
    • long-chain fatty acid metabolic process
    • positive regulation of fatty acid beta-oxidation
    • protein homooligomerization
    • regulation of fatty acid oxidation
    • regulation of insulin secretion
    • triglyceride metabolic process
  • performs the following molecular functions:
    • carnitine O-palmitoyltransferase activity
    • identical protein binding
  • is located in the following cellular components:
    • integral to membrane
    • integral to mitochondrial outer membrane
    • intracellular membrane-bounded organelle
    • mitochondrial outer membrane
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Cpt1a encodes a protein or proteins that contain the following InterPro domains: Acyltransferase ChoActase/COT/CPT, indicating that the gene product:
  • performs the following molecular functions:
    • transferase activity, transferring acyl groups

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cpt1a indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
    • transport
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • membrane

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References

1. Da Cruz S et al. (2003) Proteomic analysis of the mouse liver mitochondrial inner membrane. J Biol Chem, 278:41566-71. (PubMed:12865426)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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