Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Darc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Darc
  • participates in the following biological processes:
    • inflammatory response ^[1]
    • regulation of chemokine production ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Darc:
  • performs the following molecular functions:
    • C-C chemokine binding

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Summary text based on GO annotations supported by structural data

• Darc encodes a protein or proteins that contain the following InterPro domains: Duffy antigen/chemokine receptor, indicating that the gene product:
  • performs the following molecular functions:
    • chemokine binding
    • chemokine receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Darc indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Dawson TC et al. (2000) Exaggerated response to endotoxin in mice lacking the duffy antigen/receptor for chemokines (DARC) Blood, 96:1681-4. (PubMed:10961863)
2. Mei J et al. (2010) CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity, 33:106-17. (PubMed:20643340)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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