Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nrxn1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nrxn1
  • participates in the following biological processes:
    • gephyrin clustering ^[3]
    • neuroligin clustering ^[3]
    • positive regulation of synapse maturation ^[1]
    • postsynaptic density protein 95 clustering ^[3]
    • postsynaptic membrane assembly ^[3]
  • performs the following molecular functions:
    • acetylcholine receptor binding ^[1]
  • is located in the following cellular components:
    • cell surface ^[3]
    • presynaptic membrane ^[6]
• The gene product of Nrxn1 has been shown to bind to the gene products of Cbln1, Cbln2, Cbln4, Clstn3. ^{[4, 5, 8]} Researchers have inferred, based on physical interactions, that the gene product of Nrxn1
  • performs the following molecular functions:
    • cell adhesion molecule binding ^[3]
    • neuroligin family protein binding ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nrxn1
  • participates in the following biological processes:
    • adult behavior ^[2]
    • learning ^[2]
    • neuromuscular process controlling balance ^[2]
    • positive regulation of excitatory postsynaptic membrane potential ^[2]
    • positive regulation of synaptic transmission, glutamatergic ^[2]
    • prepulse inhibition ^[2]
    • regulation of grooming behavior ^[2]
    • regulation of insulin secretion involved in cellular response to glucose stimulus ^[7]
• Researchers have inferred, based on genetic interactions, that the gene product of Nrxn1
  • participates in the following biological processes:
    • neurotransmitter secretion based on interactions with Nrxn2, Nrxn3 ^[6]
    • positive regulation of synapse assembly based on interactions with Cbln1, Cbln2 ^[4]
    • synapse assembly based on interactions with Nrxn2, Nrxn3 ^[6]
    • synaptic transmission based on interactions with Nrxn2, Nrxn3 ^[6]
  • performs the following molecular functions:
    • calcium channel regulator activity based on interactions with Nrxn2, Nrxn3 ^[6]
  • is located in the following cellular components:
    • cell based on interactions with Nrxn2, Nrxn3 ^[6]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Nrxn1
  • is located in the following cellular components:
    • plasma membrane ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nrxn1:
  • participates in the following biological processes:
    • adult behavior
    • learning
    • protein heterotetramerization
    • social behavior
    • vesicle docking involved in exocytosis
    • vocal learning
    • vocalization behavior
  • performs the following molecular functions:
    • calcium ion binding
    • cell adhesion molecule binding
    • neuroligin family protein binding
    • receptor binding
  • is located in the following cellular components:
    • cell surface
    • endocytic vesicle
    • plasma membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nrxn1 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
  • performs the following molecular functions:
    • metal ion binding
  • is located in the following cellular components:
    • cell junction
    • integral component of membrane
    • membrane
    • synapse

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References

1. Cheng SB et al. (2009) Presynaptic targeting of alpha4beta 2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. J Biol Chem, 284:23251-9. (PubMed:19567877)
2. Etherton MR et al. (2009) Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Proc Natl Acad Sci U S A, 106:17998-8003. (PubMed:19822762)
3. Gauthier J et al. (2011) Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum Genet, null:null. (PubMed:21424692)
4. Joo JY et al. (2011) Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons. Biochem Biophys Res Commun, 406:627-32. (PubMed:21356198)
5. Lim SH et al. (2009) Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn. EMBO J, 28:3564-78. (PubMed:19816407)
6. Missler M et al. (2003) Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature, 423:939-48. (PubMed:12827191)
7. Mosedale M et al. (2012) Neurexin-1alpha contributes to insulin-containing secretory granule docking. J Biol Chem, 287:6350-61. (PubMed:22235116)
8. Pettem KL et al. (2013) The Specific alpha-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development. Neuron, 80:113-28. (PubMed:24094106)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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