Automated description from the Alliance of Genome Resources
Exhibits several functions, including calcium channel regulator activity; calcium-dependent protein binding activity; and signaling receptor binding activity. Involved in several processes, including nervous system development; postsynaptic membrane organization; and regulation of synapse organization. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; axonal growth cone; and integral component of presynaptic active zone membrane. Predicted to colocalize with the slit diaphragm. Used to study autism spectrum disorder and schizophrenia. Human ortholog(s) of this gene implicated in Pitt-Hopkins-like syndrome 2. Is expressed in several structures, including limb; nervous system; neural retina; nose; and oral epithelium. Orthologous to human NRXN1 (neurexin 1).
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