Automated description from the Alliance of Genome Resources (Release 4.1.0)
Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Involved in intermediate filament organization; protein localization to cell-cell junction; and ventricular compact myocardium morphogenesis. Acts upstream of or within several processes, including cell-cell junction organization; intermediate filament cytoskeleton organization; and skin development. Located in basolateral plasma membrane; desmosome; and intercalated disc. Colocalizes with intermediate filament. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; heart; and sensory organ. Used to study Carvajal syndrome and arrhythmogenic right ventricular dysplasia 8. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; and dilated cardiomyopathy. Orthologous to human DSP (desmoplakin).