Automated description from the Alliance of Genome Resources (Release 3.1.1)
Predicted to have protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Involved in several processes, including cell-cell junction organization; intermediate filament organization; and ventricular compact myocardium morphogenesis. Localizes to basolateral plasma membrane; desmosome; and intercalated disc. Colocalizes with intermediate filament. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; heart; and sensory organ. Used to study Carvajal syndrome and arrhythmogenic right ventricular dysplasia 8. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; and dilated cardiomyopathy. Orthologous to human DSP (desmoplakin).