Automated description from the Alliance of Genome Resources
Predicted to have protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Involved in several processes, including intermediate filament organization; protein localization to adherens junction; and ventricular compact myocardium morphogenesis. Localizes to the basolateral plasma membrane; desmosome; and intercalated disc. Colocalizes with the intermediate filament. Used to study arrhythmogenic right ventricular dysplasia 8 and dilated cardiomyopathy with woolly hair and keratoderma. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; dilated cardiomyopathy; and dilated cardiomyopathy with woolly hair and keratoderma. Orthologous to human DSP (desmoplakin).