Automated description from the Alliance of Genome Resources
Exhibits phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein kinase binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of apoptotic process. Localizes to several cellular components, including the Schmidt-Lanterman incisure; myelin sheath adaxonal region; and nucleus. Used to study several diseases, including Bannayan-Riley-Ruvalcaba syndrome; Cowden syndrome; autistic disorder; endocrine gland cancer (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; breast cancer (multiple); lung non-small cell carcinoma; macrocephaly-autism syndrome; and nervous system cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog).