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Gene Ontology Classifications
phosphatase and tensin homolog

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pten. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Chang CJ et al. (2008) PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Mol Cell Biol, 28:3281-9. (PubMed:18332125)
  2. Cotter L et al. (2010) Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science, 328:1415-8. (PubMed:20448149)
  3. Fouladkou F et al. (2008) The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A, 105:8585-90. (PubMed:18562292)
  4. Fraser MM et al. (2008) Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience, 151:476-488. (PubMed:18082964)
  5. Garcia-Garcia MJ et al. (2005) Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A, 102:5913-9. (PubMed:15755804)
  6. Hamada K et al. (2005) The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev, 19:2054-65. (PubMed:16107612)
  7. Kim JY et al. (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron, 63:761-73. (PubMed:19778506)
  8. Kwon CH et al. (2006) Pten regulates neuronal arborization and social interaction in mice. Neuron, 50:377-88. (PubMed:16675393)
  9. Li W et al. (2014) PTEN degradation after ischemic stroke: a double-edged sword. Neuroscience, 274:153-61. (PubMed:24875179)
  10. Luikart BW et al. (2011) Pten knockdown in vivo increases excitatory drive onto dentate granule cells. J Neurosci, 31:4345-54. (PubMed:21411674)
  11. Ma L et al. (2005) Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev, 19:1779-86. (PubMed:16027168)
  12. Ma X et al. (2005) Targeted biallelic inactivation of Pten in the mouse prostate leads to prostate cancer accompanied by increased epithelial cell proliferation but not by reduced apoptosis. Cancer Res, 65:5730-9. (PubMed:15994948)
  13. Manning BD et al. (2005) Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev, 19:1773-8. (PubMed:16027169)
  14. Marino S et al. (2002) PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development, 129:3513-22. (PubMed:12091320)
  15. O'Donovan KJ et al. (2014) B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med, 211:801-14. (PubMed:24733831)
  16. Ogawa S et al. (2007) A seizure-prone phenotype is associated with altered free-running rhythm in Pten mutant mice. Brain Res, 1168:112-23. (PubMed:17706614)
  17. Ozcelik M et al. (2010) Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. J Neurosci, 30:4120-31. (PubMed:20237282)
  18. Page DT et al. (2009) Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci U S A, 106:1989-94. (PubMed:19208814)
  19. Pan Y et al. (2008) Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Res, 10:R5. (PubMed:18190691)
  20. Podsypanina K et al. (1999) Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci U S A, 96:1563-8. (PubMed:9990064)
  21. Robbins D et al. (2012) Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells. FEBS Lett, 586:4108-13. (PubMed:23123091)
  22. Shen WH et al. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128:157-70. (PubMed:17218262)
  23. Song MS et al. (2011) Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell, 144:187-99. (PubMed:21241890)
  24. Stambolic V et al. (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell, 95:29-39. (PubMed:9778245)
  25. Sun H et al. (1999) PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A, 96:6199-204. (PubMed:10339565)
  26. Takahashi Y et al. (2006) PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J, 25:910-20. (PubMed:16456542)
  27. Ventruti A et al. (2011) Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain. Neuroscience, 189:32-42. (PubMed:21664258)
  28. Wang S et al. (2003) Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell, 4:209-21. (PubMed:14522255)
  29. Xu B et al. (2014) PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility. Proc Natl Acad Sci U S A, 111:18643-8. (PubMed:25512490)
  30. Xu D et al. (2010) Regulation of PTEN stability and activity by Plk3. J Biol Chem, 285:39935-42. (PubMed:20940307)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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