Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein kinase binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of apoptotic process. Localizes to several cellular components, including Schmidt-Lanterman incisure; myelin sheath adaxonal region; and neuron projection. Used to study several diseases, including Bannayan-Riley-Ruvalcaba syndrome; Cowden syndrome; endocrine gland cancer (multiple); intestinal pseudo-obstruction; and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome; PTEN hamartoma tumor syndrome; breast cancer (multiple); macrocephaly-autism syndrome; and nervous system cancer (multiple). Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and sensory organ. Orthologous to human PTEN (phosphatase and tensin homolog).