Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cxcr4. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cxcr4
  • participates in the following biological processes:
    • neuron migration ^[9]
  • is located in the following cellular components:
    • cell surface ^[11]
    • cell-cell junction ^[7]
    • external side of plasma membrane ^[1]
    • growth cone ^[8]
• The gene product of Cxcr4 has been shown to bind to the gene products of Cd164. ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cxcr4
  • participates in the following biological processes:
    • ameboidal cell migration ^[2]
    • brain development ^[5]
    • germ cell development ^[9]
    • germ cell migration ^[9]
    • motor neuron axon guidance ^{[6, 8]}
    • myelin maintenance ^[10]
    • patterning of blood vessels ^[2]
    • positive regulation of oligodendrocyte differentiation ^[10]
    • regulation of cell migration ^{[5, 9]}
    • T cell proliferation ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Cxcr4
  • participates in the following biological processes:
    • regulation of cell migration based on interactions with Gab1 ^[12]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cxcr4:
  • participates in the following biological processes:
    • calcium-mediated signaling
    • cardiac muscle contraction
    • cell migration
    • cellular response to cytokine stimulus
    • chemokine-mediated signaling pathway
    • epithelial cell development
    • G-protein coupled receptor signaling pathway
    • neuron migration
    • regulation of calcium ion transport
    • regulation of chemotaxis
    • regulation of programmed cell death
    • telencephalon cell migration
  • performs the following molecular functions:
    • actin binding
    • C-X-C chemokine receptor activity
    • drug binding
    • myosin light chain binding
    • ubiquitin binding
    • ubiquitin protein ligase binding
  • is located in the following cellular components:
    • cell leading edge
    • cell surface
    • cytoplasmic membrane-bounded vesicle
    • cytoplasmic vesicle
    • early endosome
    • endosome
    • extracellular vesicular exosome
    • late endosome
    • lysosome
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Cxcr4 encodes a protein or proteins that contain the following InterPro domains: Chemokine receptor family, CXC chemokine receptor 4, CXC chemokine receptor 4 N-terminal domain, G protein-coupled receptor, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • chemotaxis
    • neutrophil activation
  • performs the following molecular functions:
    • chemokine receptor activity
    • cytokine binding
    • G-protein coupled receptor activity
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cxcr4 indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • cell junction
    • integral component of membrane
    • membrane

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References

1. Abe J et al. (2008) Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Am J Pathol, 173:1682-92. (PubMed:19008373)
2. Ara T et al. (2005) The role of CXCL12 in the organ-specific process of artery formation. Blood, 105:3155-61. (PubMed:15626744)
3. Ara T et al. (2003) A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo. J Immunol, 170:4649-55. (PubMed:12707343)
4. Bae GU et al. (2008) Regulation of myoblast motility and fusion by the CXCR4-associated sialomucin, CD164. J Biol Chem, 283:8301-9. (PubMed:18227060)
5. Bagri A et al. (2002) The chemokine SDF1 regulates migration of dentate granule cells. Development, 129:4249-60. (PubMed:12183377)
6. Lewcock JW et al. (2007) The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron, 56:604-20. (PubMed:18031680)
7. Liang Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol, 14:858-66. (PubMed:23793062)
8. Lieberam I et al. (2005) A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons. Neuron, 47:667-79. (PubMed:16129397)
9. Molyneaux KA et al. (2003) The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development, 130:4279-86. (PubMed:12900445)
10. Patel JR et al. (2010) CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proc Natl Acad Sci U S A, 107:11062-7. (PubMed:20534485)
11. Pereira LA et al. (2012) Pdgfralpha and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells. Stem Cell Res, 8:165-79. (PubMed:22265737)
12. Vasyutina E et al. (2005) CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev, 19:2187-98. (PubMed:16166380)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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