Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have several functions, including chemokine receptor activity; cytoskeletal protein binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including circulatory system development; gamete generation; and nervous system development. Localizes to cell-cell junction; external side of plasma membrane; and growth cone. Predicted to colocalize with early endosome. Is expressed in several structures, including alimentary system; cardiovascular system; extraembryonic component; nervous system; and sensory organ. Used to study WHIM syndrome. Human ortholog(s) of this gene implicated in WHIM syndrome; hematologic cancer (multiple); leukopenia; osteoporosis; and pancreatic adenocarcinoma. Orthologous to human CXCR4 (C-X-C motif chemokine receptor 4).
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