GO Annotations Graph

• Symbol: Cxcr4
• Name: chemokine (C-X-C motif) receptor 4
• ID: MGI:109563

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Wed Mar 2 12:11:24 2016.

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0016494	C-X-C chemokine receptor activity	ISO	J:155856
Molecular Function	GO:0004950	chemokine receptor activity	IEA	J:72247
Molecular Function	GO:0019955	cytokine binding	IEA	J:72247
Molecular Function	GO:0008144	drug binding	ISO	J:155856
Molecular Function	GO:0004930	G-protein coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G-protein coupled receptor activity	IEA	J:60000
Molecular Function	GO:0032027	myosin light chain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:135334
Molecular Function	GO:0004871	signal transducer activity	IEA	J:60000
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0031252	cell leading edge	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:190263
Cellular Component	GO:0009986	cell surface	ISO	J:200103
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0016023	cytoplasmic, membrane-bounded vesicle	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0030426	growth cone	IDA	J:101029
Cellular Component	GO:0016021	integral component of membrane	IEA	J:72247
Cellular Component	GO:0016021	integral component of membrane	IEA	J:60000
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Biological Process	GO:0001667	ameboidal-type cell migration	IMP	J:98453
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:0007420	brain development	IMP	J:79852
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:147597
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:155856
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	ISO	J:155856
Biological Process	GO:0006935	chemotaxis	IEA	J:72247
Biological Process	GO:0002064	epithelial cell development	ISO	J:155856
Biological Process	GO:0007186	G-protein coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007281	germ cell development	IMP	J:84597
Biological Process	GO:0008354	germ cell migration	IMP	J:84597
Biological Process	GO:0035701	hematopoietic stem cell migration	IMP	J:178186
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:132726
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:101029
Biological Process	GO:0043217	myelin maintenance	IMP	J:161391
Biological Process	GO:0007399	nervous system development	TAS	J:69255
Biological Process	GO:0001764	neuron migration	IDA	J:84597
Biological Process	GO:0001764	neuron migration	ISO	J:155856
Biological Process	GO:0042119	neutrophil activation	IEA	J:72247
Biological Process	GO:0009887	organ morphogenesis	TAS	J:69256
Biological Process	GO:0001569	patterning of blood vessels	IMP	J:98453
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IMP	J:161391
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:178186
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0030334	regulation of cell migration	IMP	J:84597
Biological Process	GO:0030334	regulation of cell migration	IGI	J:100909
Biological Process	GO:0030334	regulation of cell migration	IMP	J:79852
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:164563
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:155856
Biological Process	GO:0043067	regulation of programmed cell death	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0042098	T cell proliferation	IMP	J:82996
Biological Process	GO:0022029	telencephalon cell migration	ISO	J:155856
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---