Cxcr4 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Cxcr4
C-X-C motif chemokine receptor 4
MGI:109563

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003779	actin binding	ISO	J:164563
Molecular Function	GO:0019957	C-C chemokine binding	ISO	J:164563
Molecular Function	GO:0038147	C-X-C motif chemokine 12 receptor activity	ISO	J:164563
Molecular Function	GO:0004950	chemokine receptor activity	IEA	J:72247
Molecular Function	GO:0019955	cytokine binding	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0032027	myosin light chain binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:135334
Molecular Function	GO:0005515	protein binding	IPI	J:284781
Molecular Function	GO:0036094	small molecule binding	ISO	J:155856
Molecular Function	GO:0043130	ubiquitin binding	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:164563
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0031252	cell leading edge	ISO	J:164563
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0009986	cell surface	IDA	J:190263
Cellular Component	GO:0009986	cell surface	ISO	J:200103
Cellular Component	GO:0005911	cell-cell junction	IDA	J:205441
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0031410	cytoplasmic vesicle	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:155856
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005769	early endosome	ISO	J:164563
Cellular Component	GO:0005768	endosome	ISO	J:155856
Cellular Component	GO:0009897	external side of plasma membrane	IDA	J:141392
Cellular Component	GO:0031012	extracellular matrix	ISO	J:155856
Cellular Component	GO:0030426	growth cone	IDA	J:101029
Cellular Component	GO:0005770	late endosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0005764	lysosome	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:160174
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Biological Process	GO:0009887	animal organ morphogenesis	TAS	J:69256
Biological Process	GO:0035904	aorta development	IMP	J:222159
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:98453
Biological Process	GO:0043534	blood vessel endothelial cell migration	IMP	J:98453
Biological Process	GO:0007420	brain development	IBA	J:265628
Biological Process	GO:0007420	brain development	IMP	J:79852
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:98453
Biological Process	GO:0001569	branching involved in blood vessel morphogenesis	IMP	J:98453
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:147597
Biological Process	GO:0060048	cardiac muscle contraction	ISO	J:155856
Biological Process	GO:0016477	cell migration	ISO	J:155856
Biological Process	GO:0071345	cellular response to cytokine stimulus	ISO	J:164563
Biological Process	GO:0071345	cellular response to cytokine stimulus	IDA	J:37252
Biological Process	GO:0071417	cellular response to organonitrogen compound	ISO	J:155856
Biological Process	GO:0006935	chemotaxis	IEA	J:72247
Biological Process	GO:0038160	CXCL12-activated CXCR4 signaling pathway	ISO	J:164563
Biological Process	GO:0038160	CXCL12-activated CXCR4 signaling pathway	IDA	J:284781
Biological Process	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	ISO	J:155856
Biological Process	GO:0045446	endothelial cell differentiation	ISO	J:155856
Biological Process	GO:0061154	endothelial tube morphogenesis	ISO	J:155856
Biological Process	GO:0002064	epithelial cell development	ISO	J:155856
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048699	generation of neurons	IEP	J:169939
Biological Process	GO:0007281	germ cell development	IMP	J:84597
Biological Process	GO:0008354	germ cell migration	IMP	J:84597
Biological Process	GO:0035701	hematopoietic stem cell migration	IMP	J:178186
Biological Process	GO:0006955	immune response	IBA	J:265628
Biological Process	GO:0001822	kidney development	IMP	J:231949
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:101029
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:132726
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:101029
Biological Process	GO:0043217	myelin maintenance	IMP	J:161391
Biological Process	GO:0007399	nervous system development	TAS	J:69255
Biological Process	GO:0061351	neural precursor cell proliferation	IEP	J:169939
Biological Process	GO:0022008	neurogenesis	ISO	J:155856
Biological Process	GO:0022008	neurogenesis	IBA	J:265628
Biological Process	GO:0001764	neuron migration	ISO	J:155856
Biological Process	GO:0001764	neuron migration	IDA	J:84597
Biological Process	GO:0090280	positive regulation of calcium ion import	IDA	J:37252
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0050921	positive regulation of chemotaxis	ISO	J:155856
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:217569
Biological Process	GO:1903861	positive regulation of dendrite extension	ISO	J:155856
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	IMP	J:160174
Biological Process	GO:2000448	positive regulation of macrophage migration inhibitory factor signaling pathway	ISO	J:164563
Biological Process	GO:1905322	positive regulation of mesenchymal stem cell migration	ISO	J:155856
Biological Process	GO:0050769	positive regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0048714	positive regulation of oligodendrocyte differentiation	IMP	J:161391
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:178186
Biological Process	GO:0035470	positive regulation of vascular wound healing	ISO	J:155856
Biological Process	GO:0051924	regulation of calcium ion transport	ISO	J:155856
Biological Process	GO:0030155	regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030334	regulation of cell migration	IMP	J:84597
Biological Process	GO:0030334	regulation of cell migration	IGI	J:100909
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:164563
Biological Process	GO:0050920	regulation of chemotaxis	ISO	J:155856
Biological Process	GO:2001222	regulation of neuron migration	IMP	J:79852
Biological Process	GO:0043067	regulation of programmed cell death	ISO	J:155856
Biological Process	GO:0050792	regulation of viral process	ISO	J:155856
Biological Process	GO:0014070	response to organic cyclic compound	ISO	J:155856
Biological Process	GO:1901327	response to tacrolimus	ISO	J:155856
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0042098	T cell proliferation	IMP	J:82996
Biological Process	GO:0022029	telencephalon cell migration	ISO	J:155856
Biological Process	GO:0003281	ventricular septum development	IMP	J:222159

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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