Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Jag1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Jag1
  • participates in the following biological processes:
    • negative regulation of fat cell differentiation ^[10]
    • positive regulation of myeloid cell differentiation ^[11]
    • positive regulation of Notch signaling pathway ^{[11, 14]}
    • response to muramyl dipeptide ^[1]
  • is located in the following cellular components:
    • apical part of cell ^[4]
    • plasma membrane ^{[3, 7]}
• The gene product of Jag1 has been shown to bind to the gene products of Mib1, Notch1. ^{[7, 14]} Researchers have inferred, based on physical interactions, that the gene product of Jag1
  • performs the following molecular functions:
    • Notch binding ^[12]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Jag1
  • participates in the following biological processes:
    • aorta morphogenesis ^[5]
    • auditory receptor cell differentiation ^[3]
    • cardiac neural crest cell development involved in outflow tract morphogenesis ^[5]
    • cardiac right ventricle morphogenesis ^[5]
    • cardiac septum morphogenesis ^[5]
    • endocardial cushion cell development ^[5]
    • inner ear development ^[2]
    • morphogenesis of an epithelial sheet ^[9]
    • negative regulation of cell differentiation ^[6]
    • negative regulation of neuron differentiation ^[8]
    • Notch signaling involved in heart development ^[5]
    • organ morphogenesis ^[13]
    • positive regulation of transcription from RNA polymerase II promoter ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Jag1:
  • participates in the following biological processes:
    • auditory receptor cell differentiation
    • negative regulation of cell differentiation
    • negative regulation of stem cell differentiation
    • Notch signaling involved in heart development
    • Notch signaling pathway
    • positive regulation of transcription from RNA polymerase II promoter
    • pulmonary artery morphogenesis
    • pulmonary valve morphogenesis
    • regulation of cell proliferation
  • is located in the following cellular components:
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Jag1 encodes a protein or proteins that contain the following InterPro domains: Delta/Serrate/lag-2 (DSL) protein, EGF-like calcium-binding, EGF-like calcium-binding, conserved site, EGF-like, conserved site, EGF-type aspartate/asparagine hydroxylation site, Epidermal growth factor-like domain, Jagged/Serrate protein, Notch ligand, N-terminal, von Willebrand factor, type C, indicating that the gene product:
  • participates in the following biological processes:
    • cell communication
    • multicellular organismal development
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Jag1 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Bansal K et al. (2011) Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J Biol Chem, 286:5823-35. (PubMed:21156799)
2. Bosman EA et al. (2009) Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol, 328:285-96. (PubMed:19389353)
3. Brooker R et al. (2006) Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development, 133:1277-86. (PubMed:16495313)
4. Chen L et al. (2005) Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol, 288:F939-52. (PubMed:15821257)
5. High FA et al. (2009) Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest, 119:1986-96. (PubMed:19509466)
6. Kong Y et al. (2004) Functional diversity of notch family genes in fetal lung development. Am J Physiol Lung Cell Mol Physiol, 286:L1075-83. (PubMed:15064243)
7. Koo BK et al. (2005) Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development, 132:3459-70. (PubMed:16000382)
8. Marklund U et al. (2010) Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development, 137:437-45. (PubMed:20081190)
9. McCright B et al. (2002) A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development, 129:1075-82. (PubMed:11861489)
10. Ross DA et al. (2004) Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Mol Cell Biol, 24:3505-13. (PubMed:15060169)
11. Rupec RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity, 22:479-91. (PubMed:15845452)
12. Shimizu K et al. (1999) Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem, 274:32961-9. (PubMed:10551863)
13. Tsai H et al. (2001) The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Hum Mol Genet, 10:507-12. (PubMed:11181574)
14. Yang LT et al. (2005) Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell, 16:927-42. (PubMed:15574878)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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