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Gene Ontology Classifications
jagged 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Jag1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bansal K et al. (2011) Intracellular pathogen sensor NOD2 programs macrophages to trigger Notch1 activation. J Biol Chem, 286:5823-35. (PubMed:21156799)
  2. Bosman EA et al. (2009) Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome. Dev Biol, 328:285-96. (PubMed:19389353)
  3. Brooker R et al. (2006) Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development, 133:1277-86. (PubMed:16495313)
  4. Chen L et al. (2005) Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol, 288:F939-52. (PubMed:15821257)
  5. Falix FA et al. (2014) Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning. Dev Biol, 396:201-13. (PubMed:25446530)
  6. High FA et al. (2009) Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest, 119:1986-96. (PubMed:19509466)
  7. James AC et al. (2014) Notch4 reveals a novel mechanism regulating Notch signal transduction. Biochim Biophys Acta, 1843:1272-84. (PubMed:24667410)
  8. Kong Y et al. (2004) Functional diversity of notch family genes in fetal lung development. Am J Physiol Lung Cell Mol Physiol, 286:L1075-83. (PubMed:15064243)
  9. Koo BK et al. (2005) Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development, 132:3459-70. (PubMed:16000382)
  10. Marklund U et al. (2010) Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development, 137:437-45. (PubMed:20081190)
  11. Maruyama K et al. (2013) Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med, 210:1947-60. (PubMed:23980096)
  12. McCright B et al. (2002) A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development, 129:1075-82. (PubMed:11861489)
  13. Ross DA et al. (2004) Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Mol Cell Biol, 24:3505-13. (PubMed:15060169)
  14. Rupec RA et al. (2005) Stroma-mediated dysregulation of myelopoiesis in mice lacking I kappa B alpha. Immunity, 22:479-91. (PubMed:15845452)
  15. Shimizu K et al. (1999) Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods. J Biol Chem, 274:32961-9. (PubMed:10551863)
  16. Tsai H et al. (2001) The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti. Hum Mol Genet, 10:507-12. (PubMed:11181574)
  17. Xue Y et al. (1999) Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Hum Mol Genet, 8:723-30. (PubMed:10196361)
  18. Yang LT et al. (2005) Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell, 16:927-42. (PubMed:15574878)
  19. Zhou Y et al. (2013) Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye. Proc Natl Acad Sci U S A, 110:8966-71. (PubMed:23676271)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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