Automated description from the Alliance of Genome Resources
Exhibits Notch binding activity. Involved in several processes, including animal organ development; negative regulation of cell differentiation; and positive regulation of cell differentiation. Localizes to the adherens junction and apical plasma membrane. Predicted to colocalize with the membrane. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).