Automated description from the Alliance of Genome Resources (Release 3.1)
Exhibits Notch binding activity. Involved in several processes, including animal organ development; negative regulation of cell differentiation; and positive regulation of cell differentiation. Localizes to adherens junction and apical plasma membrane. Predicted to colocalize with membrane. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study Alagille syndrome. Human ortholog(s) of this gene implicated in Alagille syndrome; congenital heart disease; multiple sclerosis; and tetralogy of Fallot. Orthologous to human JAG1 (jagged canonical Notch ligand 1).