About   Help   FAQ
Gene Ontology Classifications
transient receptor potential cation channel, subfamily C, member 2

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Trpc2. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of October 6, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Chu X et al. (2004) Interaction of TRPC2 and TRPC6 in erythropoietin modulation of calcium influx. J Biol Chem, 279:10514-22. (PubMed:14699131)
  2. Ferrero DM et al. (2013) A juvenile mouse pheromone inhibits sexual behaviour through the vomeronasal system. Nature, null:null. (PubMed:24089208)
  3. Hofmann T et al. (2000) Cloning, expression and subcellular localization of two novel splice variants of mouse transient receptor potential channel 2. Biochem J, 351:115-22. (PubMed:10998353)
  4. Jungnickel MK et al. (2001) Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3. Nat Cell Biol, 3:499-502. (PubMed:11331878)
  5. Kimchi T et al. (2007) A functional circuit underlying male sexual behaviour in the female mouse brain. Nature, 448:1009-14. (PubMed:17676034)
  6. Leypold BG et al. (2002) Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A, 99:6376-81. (PubMed:11972034)
  7. Lucas P et al. (2003) A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron, 40:551-61. (PubMed:14642279)
  8. Prince JE et al. (2013) Kirrel3 is required for the coalescence of vomeronasal sensory neuron axons into glomeruli and for male-male aggression. Development, 140:2398-408. (PubMed:23637329)
  9. Stowers L et al. (2002) Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science, 295:1493-500. (PubMed:11823606)
  10. Vannier B et al. (1999) Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative Ca2+ entry channel. Proc Natl Acad Sci U S A, 96:2060-4. (PubMed:10051594)
  11. Yildirim E et al. (2003) The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. Proc Natl Acad Sci U S A, 100:2220-5. (PubMed:12601176)
  12. Yuan JP et al. (2003) Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell, 114:777-89. (PubMed:14505576)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory