Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables centromeric DNA binding activity and damaged DNA binding activity. Acts upstream of or within mismatch repair and somatic recombination of immunoglobulin gene segments. Predicted to be part of MutSbeta complex. Predicted to be active in nucleus. Is expressed in early conceptus; oocyte; and secondary oocyte. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3).