Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein heterodimerization activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of cold-induced thermogenesis; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm; nuclear speck; and transcription factor complex. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human EPAS1 (endothelial PAS domain protein 1).