Automated description from the Alliance of Genome Resources
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including SMAD protein signal transduction; lipid homeostasis; and regulation of gene expression. Localizes to the nucleus. Used to study maturity-onset diabetes of the young type 1. Human ortholog(s) of this gene implicated in Fanconi syndrome; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).