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Gene Ontology Classifications
hepatic nuclear factor 4, alpha

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Hnf4a. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ang SL et al. (1993) The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins. Development, 119:1301-15. (PubMed:8306889)
  2. Antes TJ et al. (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5' of the apolipoprotein B gene, that confers expression in the intestine J Biol Chem, 275:26637-48. (PubMed:10859308)
  3. Briancon N et al. (2006) In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. EMBO J, 25:1253-62. (PubMed:16498401)
  4. Chen WS et al. (1994) Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev, 8:2466-77. (PubMed:7958910)
  5. Duncan SA et al. (1997) Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. Development, 124:279-87. (PubMed:9053305)
  6. Faure AJ et al. (2012) Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res, 22:2163-75. (PubMed:22780989)
  7. Furihata T et al. (2006) Hepatocyte nuclear factor-4alpha plays pivotal roles in the regulation of mouse carboxylesterase 2 gene transcription in mouse liver. Arch Biochem Biophys, 447:107-17. (PubMed:16527247)
  8. Gupta RK et al. (2005) The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest, 115:1006-1015. (PubMed:15761495)
  9. Hayhurst GP et al. (2001) Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol, 21:1393-403. (PubMed:11158324)
  10. Kamiya A et al. (2004) Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver. FEBS Lett, 578:63-8. (PubMed:15581617)
  11. Kyrmizi I et al. (2006) Plasticity and expanding complexity of the hepatic transcription factor network during liver development. Genes Dev, 20:2293-305. (PubMed:16912278)
  12. Laz EV et al. (2007) Characterization of three growth hormone-responsive transcription factors preferentially expressed in adult female liver. Endocrinology, 148:3327-37. (PubMed:17412818)
  13. Lee D et al. (2008) ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell, 2:497-507. (PubMed:18462699)
  14. Nakhei H et al. (1998) An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell types. Nucleic Acids Res, 26:497-504. (PubMed:9421506)
  15. Pare JF et al. (2004) The fetoprotein transcription factor (FTF) gene is essential to embryogenesis and cholesterol homeostasis and is regulated by a DR4 element. J Biol Chem, 279:21206-16. (PubMed:15014077)
  16. Ponugoti B et al. (2007) Functional Interaction of Hepatic Nuclear Factor-4 and Peroxisome Proliferator-Activated Receptor-{gamma} Coactivator 1{alpha} in CYP7A1 Regulation Is Inhibited by a Key Lipogenic Activator, Sterol Regulatory Element-Binding Protein-1c. Mol Endocrinol, 21:2698-712. (PubMed:17636037)
  17. Qu X et al. (2007) Cited2, a coactivator of HNF4alpha, is essential for liver development. EMBO J, 26:4445-56. (PubMed:17932483)
  18. Sadagurski M et al. (2006) Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation. Mol Cell Biol, 26:2675-87. (PubMed:16537911)
  19. Sato Y et al. (2012) Anks4b, a novel target of HNF4alpha protein, interacts with GRP78 protein and regulates endoplasmic reticulum stress-induced apoptosis in pancreatic beta-cells. J Biol Chem, 287:23236-45. (PubMed:22589549)
  20. Schmutz I et al. (2010) The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors. Genes Dev, 24:345-57. (PubMed:20159955)
  21. Sirard C et al. (1998) The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev, 12:107-19. (PubMed:9420335)
  22. Yamasaki H et al. (2006) Suppression of C/EBP{alpha} expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression. Development, 133:4233-43. (PubMed:17021047)
  23. Yokomori N et al. (1997) Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver. J Steroid Biochem Mol Biol, 62:307-14. (PubMed:9408084)
  24. Zhao R et al. (2005) GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol, 25:2622-31. (PubMed:15767668)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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