Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including SMAD protein signal transduction; lipid homeostasis; and regulation of gene expression. Localizes to nucleus. Is expressed in several structures, including ear; early conceptus; gut; metanephros; and nervous system. Used to study Fanconi syndrome and maturity-onset diabetes of the young type 1. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha).