Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables Wnt receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of neuron projection arborization; and vasculature development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; progesterone secretion; and vasculature development. Located in cell-cell junction; dendrite; and plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4).