Automated description from the Alliance of Genome Resources
Exhibits Wnt-activated receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; regulation of transcription, DNA-templated; and vasculature development. Localizes to several cellular components, including the cell-cell junction; dendrite; and glutamatergic synapse. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to human FZD4 (frizzled class receptor 4).