Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including ionotropic glutamate receptor binding activity; modification-dependent protein binding activity; and molecular condensate scaffold activity. Involved in several processes, including aggrephagy; brown fat cell proliferation; and positive regulation of long-term synaptic potentiation. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in several cellular components, including aggresome; autolysosome; and sperm midpiece. Is active in intracellular non-membrane-bounded organelle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis-3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1).