Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including negative regulation of nitrogen compound metabolic process; positive regulation of long-term synaptic potentiation; and positive regulation of protein localization to plasma membrane. Localizes to several cellular components, including aggresome; autolysosome; and sperm midpiece. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in Paget's disease of bone and frontotemporal dementia and/or amyotrophic lateral sclerosis-3. Orthologous to human SQSTM1 (sequestosome 1).