Automated description from the Alliance of Genome Resources
Exhibits K63-linked polyubiquitin modification-dependent protein binding activity; identical protein binding activity; and ionotropic glutamate receptor binding activity. Involved in several processes, including negative regulation of growth of symbiont in host; positive regulation of long-term synaptic potentiation; and positive regulation of protein localization to plasma membrane. Localizes to the aggresome; cytoplasm; and sperm midpiece. Used to study Paget's disease of bone. Human ortholog(s) of this gene implicated in FTDALS3 and Paget's disease of bone. Orthologous to human SQSTM1 (sequestosome 1).