Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits microtubule binding activity. Involved in melanosome transport. Localizes to cell leading edge; microtubule cytoskeleton; and protein-containing complex. Predicted to colocalize with retromer complex. Is expressed in brain; embryo; and head. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and distal hereditary motor neuronopathy type 7B. Orthologous to human DCTN1 (dynactin subunit 1).