Automated description from the Alliance of Genome Resources
Exhibits protein domain specific binding activity. Involved in several processes, including establishment of T cell polarity; microtubule cytoskeleton organization; and negative regulation of actin filament severing. Localizes to several cellular components, including the brush border; cytoskeleton; and uropod. Colocalizes with several cellular components, including the focal adhesion; immunological synapse; and spindle. Used to study MYH-9 related disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal failure; and proteinuria. Orthologous to human MYH9 (myosin heavy chain 9).