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Gene Ontology Classifications
interferon gamma

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ifng. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II interferon family. The protein encoded is a soluble cytokine with antiviral, immunoregulatory and anti-tumor properties and is a potent activator of macrophages. Mutations in this gene are associated with aplastic anemia.[provided by RefSeq, Nov 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity, 15:739-50. (PubMed:11728336)
  2. Amsen D et al. (2007) Direct regulation of gata3 expression determines the T helper differentiation potential of notch. Immunity, 27:89-99. (PubMed:17658279)
  3. Basler M et al. (2004) Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus. J Immunol, 173:3925-34. (PubMed:15356141)
  4. Brass AL et al. (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell, 139:1243-54. (PubMed:20064371)
  5. Bune AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology, 102:103-13. (PubMed:11168643)
  6. Celada A et al. (1989) The expression of I-A correlates with the uptake of interferon-gamma by macrophages. Eur J Immunol, 19:205-8. (PubMed:2493384)
  7. Celada A et al. (1991) IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway. J Immunol, 146:114-20. (PubMed:1845803)
  8. Celada A et al. (1989) Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages. Eur J Immunol, 19:1103-9. (PubMed:2502420)
  9. Chae WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A, 103:9631-6. (PubMed:16769892)
  10. Chen Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR Nature, 407:916-20. (PubMed:11057672)
  11. Collazo CM et al. (2001) Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J Exp Med, 194:181-8. (PubMed:11457893)
  12. Dai R et al. (2008) Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood, 112:4591-7. (PubMed:18791161)
  13. Dardalhon V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol, 9:1347-55. (PubMed:18997793)
  14. Day EB et al. (2011) Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc Natl Acad Sci U S A, 108:9536-41. (PubMed:21606376)
  15. Degrandi D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol, 179:7729-40. (PubMed:18025219)
  16. Deshmukh HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect Immun, 77:1376-82. (PubMed:19139201)
  17. Du C et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat Immunol, 10:1252-9. (PubMed:19838199)
  18. Fulcher AJ et al. (2008) Interferon gamma is recognised by importin alpha/beta: enhanced nuclear localising and transactivation activities of an interferon gamma mimetic. FEBS Lett, 582:1569-74. (PubMed:18405666)
  19. Gerth AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int Immunol, 15:937-44. (PubMed:12882831)
  20. Guo L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A, 106:13463-8. (PubMed:19666510)
  21. Hervas-Stubbs S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J Immunol, 178:2361-9. (PubMed:17277142)
  22. Hu J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J Biol Chem, 277:30253-63. (PubMed:12050152)
  23. Ioan-Facsinay A et al. (2002) FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity, 16:391-402. (PubMed:11911824)
  24. Kim PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol, 177:6650-9. (PubMed:17082577)
  25. Kobayashi K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature, 416:194-9. (PubMed:11894098)
  26. Li Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat Immunol, 12:178-85. (PubMed:21217760)
  27. Lin W et al. (2005) Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J Cell Biol, 169:603-12. (PubMed:15911877)
  28. Lin W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J Allergy Clin Immunol, 116:1106-15. (PubMed:16275384)
  29. Liu J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J Exp Med, 198:1265-76. (PubMed:14568984)
  30. McKee AS et al. (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol, 173:1224-31. (PubMed:15240714)
  31. McLoughlin RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest, 112:598-607. (PubMed:12925700)
  32. Moriggl R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity, 10:249-59. (PubMed:10072077)
  33. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol, 12:450-9. (PubMed:21460847)
  34. Nishimura H et al. (2005) A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. J Immunol, 175:4627-34. (PubMed:16177108)
  35. Onodera A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J Exp Med, 207:2493-506. (PubMed:20956546)
  36. Scharton-Kersten T et al. (1997) Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J Exp Med, 186:1523-34. (PubMed:9348310)
  37. Schiavoni G et al. (2004) Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway. J Immunol, 173:1266-75. (PubMed:15240719)
  38. Shang L et al. (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J Biol Chem, 281:1876-84. (PubMed:16280321)
  39. Sharma S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc Natl Acad Sci U S A, 108:11381-6. (PubMed:21709260)
  40. Stellato C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J Immunol, 187:441-9. (PubMed:21613615)
  41. Walter W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br J Cancer, 83:1192-201. (PubMed:11027433)
  42. Wang L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur J Immunol, 40:2385-90. (PubMed:20706986)
  43. Watanabe T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol, 5:800-8. (PubMed:15220916)
  44. Yagi R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity, 32:507-17. (PubMed:20399120)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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