Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Larp7. (This text reflects annotations as of Wednesday, August 14, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 11, 2013. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which is found in the 7SK snRNP (small nuclear ribonucleoprotein). This snRNP complex inhibits a cyclin-dependent kinase, positive transcription elongation factor b, which is required for paused RNA polymerase II at a promoter to begin transcription elongation. A pseudogene of this gene is located on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Larp7
  • participates in the following biological processes:
    • germ cell proliferation ^[1]
    • positive regulation of G1/S transition of mitotic cell cycle ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Larp7
  • participates in the following biological processes:
    • negative regulation of chromatin binding based on interactions with Mepce ^[1]
    • negative regulation of transcription from RNA polymerase II promoter based on interactions with Mepce ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Larp7:
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Larp7 encodes a protein or proteins that contain the following InterPro domains: Lupus La protein, Nucleotide-binding, alpha-beta plait, RNA recognition motif domain, RNA-binding motif, RNA-binding protein Lupus La, Winged helix-turn-helix DNA-binding domain, indicating that the gene product:
  • participates in the following biological processes:
    • RNA processing
  • performs the following molecular functions:
    • nucleic acid binding
    • nucleotide binding
    • RNA binding
  • is located in the following cellular components:
    • ribonucleoprotein complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Larp7 indicates that it:
  • performs the following molecular functions:
    • RNA binding
• Annotations directly to for the gene Larp7 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Okamura D et al. (2012) Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev, 26:2477-82. (PubMed:23154982)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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