Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Zic1. (This text reflects annotations as of Tuesday, May 21, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Zic1
  • participates in the following biological processes:
    • brain development ^[1]
    • pattern specification process ^[9]
    • positive regulation of protein import into nucleus ^[6]
    • positive regulation of transcription, DNA-dependent ^{[5, 6, 8]}
  • performs the following molecular functions:
    • sequence-specific DNA binding transcription factor activity ^{[5, 8]}
  • is located in the following cellular components:
    • cytoplasm ^[7]
    • nucleus ^{[6, 7]}
• The gene product of Zic1 has been shown to bind to the gene products of Gli2, Mdfic. ^{[6, 7]} Researchers have inferred, based on physical interactions, that the gene product of Zic1
  • participates in the following biological processes:
    • regulation of smoothened signaling pathway ^[6]
  • performs the following molecular functions:
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Zic1
  • participates in the following biological processes:
    • adult walking behavior ^[2]
    • central nervous system development ^[2]
    • spinal cord development ^[3]
• Researchers have inferred, based on genetic interactions, that the gene product of Zic1
  • participates in the following biological processes:
    • central nervous system development based on interactions with Zic2 ^[4]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Zic1:
  • participates in the following biological processes:
    • brain development
  • is located in the following cellular components:
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Zic1 encodes a protein or proteins that contain the following InterPro domains: Zinc finger C2H2-type/integrase DNA-binding domain, Zinc finger, C2H2, Zinc finger, C2H2-like, indicating that the gene product:
  • performs the following molecular functions:
    • metal ion binding
    • nucleic acid binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Zic1 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
    • metal ion binding

---

References

1. Aruga J et al. (1994) A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells. J Neurochem, 63:1880-90. (PubMed:7931345)
2. Aruga J et al. (1998) Mouse Zic1 is involved in cerebellar development. J Neurosci, 18:284-93. (PubMed:9412507)
3. Aruga J et al. (2002) Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. Dev Biol, 244:329-41. (PubMed:11944941)
4. Aruga J et al. (2002) Zic2 controls cerebellar development in cooperation with zic1. J Neurosci, 22:218-25. (PubMed:11756505)
5. Ishiguro A et al. (2004) Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. Biochem Biophys Res Commun, 324:302-7. (PubMed:15465018)
6. Koyabu Y et al. (2001) Physical and functional interactions between Zic and Gli proteins. J Biol Chem, 276:6889-92. (PubMed:11238441)
7. Mizugishi K et al. (2004) Myogenic repressor I-mfa interferes with the function of Zic family proteins. Biochem Biophys Res Commun, 320:233-40. (PubMed:15207726)
8. Mizugishi K et al. (2001) Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem, 276:2180-8. (PubMed:11053430)
9. Nagai T et al. (1997) The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation. Dev Biol, 182:299-313. (PubMed:9070329)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---