Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Neurod6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on genetic interactions, that the gene product of Neurod6
  • participates in the following biological processes:
    • dentate gyrus development based on interactions with Neurod1 ^[1]

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Summary text based on GO annotations supported by structural data

• Neurod6 encodes a protein or proteins that contain the following InterPro domains: Helix-loop-helix domain, Neurogenic differentiation factor, domain of unknown function, Transcription factor, basic helix-loop-helix, NeuroD, indicating that the gene product:
  • performs the following molecular functions:
    • protein dimerization activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Neurod6 indicates that it:
  • participates in the following biological processes:
    • cell differentiation
    • multicellular organismal development
    • nervous system development
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent
  • performs the following molecular functions:
    • DNA binding
  • is located in the following cellular components:
    • nucleus

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References

1. Schwab MH et al. (2000) Neuronal basic helix-loop-helix proteins (NEX and BETA2/Neuro D) regulate terminal granule cell differentiation in the hippocampus. J Neurosci, 20:3714-24. (PubMed:10804213)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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