About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Cdc42
cell division cycle 42
MGI:106211

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdc42. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Aoki K et al. (2005) Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell, 16:2207-17. (PubMed:15728722)
  2. Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci, 9:1099-107. (PubMed:16892058)
  3. Chiang SH et al. (2003) TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport. EMBO J, 22:2679-91. (PubMed:12773384)
  4. Gakidis MA et al. (2004) Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol, 166:273-82. (PubMed:15249579)
  5. Gomes ER et al. (2005) Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell, 121:451-63. (PubMed:15882626)
  6. Haebig K et al. (2010) ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One, 5:e13762. (PubMed:21048939)
  7. Harada Y et al. (2012) DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood, 119:4451-61. (PubMed:22461490)
  8. Hirsch DS et al. (2001) A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. J Biol Chem, 276:875-83. (PubMed:11035016)
  9. Joberty G et al. (1999) The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol, 19:6585-97. (PubMed:10490598)
  10. Johansson A et al. (2000) The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. J Cell Sci, 113:3267-75. (PubMed:10954424)
  11. Kawasaki Y et al. (2009) The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. EMBO Rep, 10:1355-62. (PubMed:19893577)
  12. Kostenko EV et al. (2006) Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol, 26:8964-75. (PubMed:17000758)
  13. Liang Y et al. (2013) The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol, 14:858-66. (PubMed:23793062)
  14. Matsuda C et al. (2008) Affixin activates Rac1 via betaPIX in C2C12 myoblast. FEBS Lett, 582:1189-96. (PubMed:18325335)
  15. Miki T et al. (1993) Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737] Nature, 362:462-5. (PubMed:8464478)
  16. Nevins AK et al. (2005) A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis. J Biol Chem, 280:1944-52. (PubMed:15537656)
  17. Nishikimi A et al. (2005) Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes. FEBS Lett, 579:1039-46. (PubMed:15710388)
  18. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)
  19. Nojima H et al. (2008) IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol, 10:971-8. (PubMed:18604197)
  20. Oh JE et al. (2009) Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway. FASEB J, 23:2088-99. (PubMed:19244314)
  21. Prakash SK et al. (2000) Functional analysis of ARHGAP6, a novel GTPase-activating protein for RhoA. Hum Mol Genet, 9:477-88. (PubMed:10699171)
  22. Qian L et al. (2011) Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species. J Cell Biol, 193:1181-96. (PubMed:21690310)
  23. Ryan XP et al. (2005) The Rho-Specific GEF Lfc Interacts with Neurabin and Spinophilin to Regulate Dendritic Spine Morphology. Neuron, 47:85-100. (PubMed:15996550)
  24. Sharma M et al. (2006) Membrane localization of adenomatous polyposis coli protein at cellular protrusions: targeting sequences and regulation by beta-catenin. J Biol Chem, 281:17140-9. (PubMed:16621792)
  25. Tunggal JA et al. (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J, 24:1146-56. (PubMed:15775979)
  26. Urena JM et al. (2005) Expression, synaptic localization, and developmental regulation of Ack1/Pyk1, a cytoplasmic tyrosine kinase highly expressed in the developing and adult brain. J Comp Neurol, 490:119-32. (PubMed:16052498)
  27. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)
  28. Wu X et al. (2008) ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell, 135:137-48. (PubMed:18854161)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory