Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of TORC1 signaling; positive regulation of Golgi lumen acidification; and proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; reproductive structure development; and sperm entry. Located in cytosol and nucleus. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; radius; and retina. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein ligase E3A).