Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables glutamate-cysteine ligase catalytic subunit binding activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; glutathione biosynthetic process; and negative regulation of extrinsic apoptotic signaling pathway. Part of glutamate-cysteine ligase complex. Is expressed in several structures, including alimentary system; liver; nervous system; urinary system; and vibrissa. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit).