Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnj6. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kcnj6
  • participates in the following biological processes:
    • regulation of ion transmembrane transport ^[2]
  • performs the following molecular functions:
    • G-protein activated inward rectifier potassium channel activity ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Kcnj6
  • participates in the following biological processes:
    • thyroid hormone metabolic process ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnj6:
  • performs the following molecular functions:
    • G-protein alpha-subunit binding
  • is located in the following cellular components:
    • axon
    • cell surface
    • cytoplasm
    • dendrite
    • Golgi apparatus
    • neuronal cell body membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Kcnj6 encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin E-set, Potassium channel, inwardly rectifying, Kir, Potassium channel, inwardly rectifying, Kir, cytoplasmic, Potassium channel, inwardly rectifying, Kir3.2, indicating that the gene product:
  • participates in the following biological processes:
    • potassium ion transport
  • performs the following molecular functions:
    • inward rectifier potassium channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnj6 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transport
    • transport
  • performs the following molecular functions:
    • ion channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Adachi K et al. (1996) Levels of thyroid hormones in the brain of ataxic mutant mice. Med Sci Res, 24:675-7.
2. Lesage F et al. (1994) Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett, 353:37-42. (PubMed:7926018)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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