Automated description from the Alliance of Genome Resources
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including NIK/NF-kappaB signaling; leukocyte differentiation; and regulation of gene expression. Localizes to the cytosol and nucleus. Predicted to colocalize with the centrosome. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and primary immunodeficiency disease. Is expressed in axial skeleton; eye; heart; and ureter. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit).