Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits Rho guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including cytoskeleton organization; generation of neurons; and negative regulation of podosome assembly. Localizes to several cellular components, including dendritic shaft; podosome; and postsynaptic density. Is expressed in several structures, including brain; dorsal root ganglion; and testis. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2).