GO Annotations Graph

• Symbol: Arhgef2
• Name: Rho/Rac guanine nucleotide exchange factor 2
• ID: MGI:103264

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:99758
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0008017	microtubule binding	ISO	J:164563
Molecular Function	GO:0008017	microtubule binding	IBA	J:265628
Molecular Function	GO:0008017	microtubule binding	IDA	J:99758
Molecular Function	GO:0005515	protein binding	IPI	J:209645
Molecular Function	GO:0005515	protein binding	IPI	J:173122
Molecular Function	GO:0005515	protein binding	IPI	J:99758
Molecular Function	GO:0005515	protein binding	IPI	J:171956
Molecular Function	GO:0005515	protein binding	IPI	J:99758
Molecular Function	GO:0031267	small GTPase binding	ISO	J:164563
Cellular Component	GO:0005923	bicellular tight junction	IEA	J:60000
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0031410	cytoplasmic vesicle	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	ISO	J:164563
Cellular Component	GO:0005856	cytoskeleton	IBA	J:265628
Cellular Component	GO:0043198	dendritic shaft	IDA	J:99758
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0005794	Golgi apparatus	IEA	J:60000
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0005874	microtubule	ISO	J:164563
Cellular Component	GO:0043025	neuronal cell body	IDA	J:99758
Cellular Component	GO:0002102	podosome	IDA	J:171956
Cellular Component	GO:0014069	postsynaptic density	IDA	J:187362
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	ISO	J:164563
Cellular Component	GO:0032587	ruffle membrane	IBA	J:265628
Cellular Component	GO:0031982	vesicle	ISO	J:164563
Biological Process	GO:0007015	actin filament organization	ISO	J:164563
Biological Process	GO:0007015	actin filament organization	IBA	J:265628
Biological Process	GO:0007015	actin filament organization	IPI	J:99758
Biological Process	GO:0007015	actin filament organization	IPI	J:99758
Biological Process	GO:0055059	asymmetric neuroblast division	IMP	J:242973
Biological Process	GO:0055059	asymmetric neuroblast division	ISO	J:164563
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0051301	cell division	IEA	J:60000
Biological Process	GO:0000902	cell morphogenesis	ISO	J:164563
Biological Process	GO:0000902	cell morphogenesis	IBA	J:265628
Biological Process	GO:0000902	cell morphogenesis	IDA	J:99758
Biological Process	GO:0071225	cellular response to muramyl dipeptide	ISO	J:164563
Biological Process	GO:0000132	establishment of mitotic spindle orientation	IMP	J:161097
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007026	negative regulation of microtubule depolymerization	ISO	J:164563
Biological Process	GO:0050768	negative regulation of neurogenesis	IMP	J:161097
Biological Process	GO:0071802	negative regulation of podosome assembly	IMP	J:171956
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0032755	positive regulation of interleukin-6 production	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	IMP	J:242973
Biological Process	GO:0045666	positive regulation of neuron differentiation	ISO	J:164563
Biological Process	GO:0045666	positive regulation of neuron differentiation	IBA	J:265628
Biological Process	GO:2001224	positive regulation of neuron migration	IMP	J:242973
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	ISO	J:164563
Biological Process	GO:0035023	regulation of Rho protein signal transduction	IBA	J:265628
Biological Process	GO:0035023	regulation of Rho protein signal transduction	IDA	J:99758