Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables NADH dehydrogenase (quinone) activity. Involved in several processes, including protein polyubiquitination; response to lipopolysaccharide; and vitamin K metabolic process. Acts upstream of or within response to oxidative stress. Is active in cytoplasm and nucleus. Is expressed in heart; liver; main olfactory bulb; olfactory epithelium; and skin. Human ortholog(s) of this gene implicated in several diseases, including hematologic cancer (multiple); hypertension; lung disease (multiple); macular degeneration; and small cell carcinoma. Orthologous to human NQO1 (NAD(P)H quinone dehydrogenase 1).