Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA binding activity and nuclear receptor activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of RNA polymerase II transcription regulator complex; chromatin; and receptor complex. Predicted to be active in nucleus. Predicted to colocalize with caveola. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); liver disease (multiple); lung disease (multiple); and melanoma (multiple). Orthologous to human VDR (vitamin D receptor).
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