Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acvr2a. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 6, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acvr2a
  • participates in the following biological processes:
    • regulation of signal transduction ^[1]
  • is located in the following cellular components:
    • cell surface ^[6]
• Researchers have inferred, based on physical interactions, that the gene product of Acvr2a
  • performs the following molecular functions:
    • activin binding ^[8]
    • growth factor binding ^[4]
    • inhibin binding ^[14]
    • PDZ domain binding ^[6]
    • protein self-association ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Acvr2a
  • participates in the following biological processes:
    • BMP signaling pathway ^[13]
    • embryonic skeletal system development ^[9]
    • male gonad development ^[9]
    • mesoderm development ^[11]
    • penile erection ^[7]
    • regulation of BMP signaling pathway ^[13]
    • regulation of nitric-oxide synthase activity ^[7]
    • Sertoli cell proliferation ^[12]
    • sperm ejaculation ^[7]
  • performs the following molecular functions:
    • growth factor binding ^[10]
• Researchers have inferred, based on genetic interactions, that the gene product of Acvr2a
  • participates in the following biological processes:
    • anterior/posterior pattern specification based on interactions with , , Acvr2b ^{[5, 11]}
    • determination of left/right symmetry based on interactions with Acvr2b ^[5]
    • gastrulation with mouth forming second based on interactions with , ^[11]
    • spermatogenesis based on interactions with , ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acvr2a:
  • participates in the following biological processes:
    • BMP signaling pathway
    • positive regulation of activin receptor signaling pathway
    • positive regulation of bone mineralization
    • positive regulation of erythrocyte differentiation
    • positive regulation of follicle-stimulating hormone secretion
    • positive regulation of osteoblast differentiation
    • positive regulation of pathway-restricted SMAD protein phosphorylation
    • positive regulation of protein phosphorylation
  • performs the following molecular functions:
    • activin binding
    • activin receptor activity, type II
    • coreceptor activity
    • inhibin binding
  • is located in the following cellular components:
    • cytoplasm
    • inhibin-betaglycan-ActRII complex

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Summary text based on GO annotations supported by structural data

• Acvr2a encodes a protein or proteins that contain the following InterPro domains: Activin type II receptor, Activin type II/Transforming growth factor-beta II receptor, Protein kinase, catalytic domain, Protein kinase-like domain, Serine/threonine-protein kinase, active site, TGF-beta receptor/activin receptor, type I/II, indicating that the gene product:
  • participates in the following biological processes:
    • activin receptor signaling pathway
    • protein phosphorylation
    • signal transduction by phosphorylation
    • transmembrane receptor protein serine/threonine kinase signaling pathway
  • performs the following molecular functions:
    • activin-activated receptor activity
    • ATP binding
    • protein kinase activity
    • protein serine/threonine kinase activity
    • receptor signaling protein serine/threonine kinase activity
    • transferase activity, transferring phosphorus-containing groups
    • transforming growth factor beta-activated receptor activity
    • transmembrane receptor protein serine/threonine kinase activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acvr2a indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • metal ion binding
    • nucleotide binding
    • protein serine/threonine kinase activity
    • transferase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol, 311:500-11. (PubMed:17936261)
2. De Winter JP et al. (1996) Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. Exp Cell Res, 224:323-34. (PubMed:8612709)
3. Kumar TR et al. (2001) Male reproductive phenotypes in double mutant mice lacking both FSHbeta and activin receptor IIA. Endocrinology, 142:3512-8. (PubMed:11459797)
4. Lee SJ et al. (2001) Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A, 98:9306-11. (PubMed:11459935)
5. Lee YJ et al. (2006) Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis, 44:487-94. (PubMed:16991118)
6. Liu ZH et al. (2006) Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling. J Endocrinol, 189:409-21. (PubMed:16648306)
7. Ma X et al. (2005) Impaired male sexual behavior in activin receptor type II knockout mice. Biol Reprod, 73:1182-90. (PubMed:16093358)
8. Mathews LS et al. (1991) Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell, 65:973-82. (PubMed:1646080)
9. Matzuk MM et al. (1995) Different phenotypes for mice deficient in either activins or activin receptor type II [see comments] Nature, 374:356-60. (PubMed:7885474)
10. Oh SP et al. (2002) Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev, 16:2749-54. (PubMed:12414726)
11. Song J et al. (1999) The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol, 213:157-69. (PubMed:10452853)
12. Wreford NG et al. (2001) Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis. Endocrinology, 142:2916-20. (PubMed:11416011)
13. Xia Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem, 282:18129-40. (PubMed:17472960)
14. Xu J et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem, 270:6308-13. (PubMed:7890768)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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