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Gene Ontology Classifications
Symbol
Name
ID
Acvr2a
activin receptor IIA
MGI:102806

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acvr2a. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 6, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol, 311:500-11. (PubMed:17936261)
  2. De Winter JP et al. (1996) Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. Exp Cell Res, 224:323-34. (PubMed:8612709)
  3. Kumar TR et al. (2001) Male reproductive phenotypes in double mutant mice lacking both FSHbeta and activin receptor IIA. Endocrinology, 142:3512-8. (PubMed:11459797)
  4. Lee SJ et al. (2001) Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A, 98:9306-11. (PubMed:11459935)
  5. Lee YJ et al. (2006) Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis, 44:487-94. (PubMed:16991118)
  6. Liu ZH et al. (2006) Characterization of isoforms of activin receptor-interacting protein 2 that augment activin signaling. J Endocrinol, 189:409-21. (PubMed:16648306)
  7. Ma X et al. (2005) Impaired male sexual behavior in activin receptor type II knockout mice. Biol Reprod, 73:1182-90. (PubMed:16093358)
  8. Mathews LS et al. (1991) Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell, 65:973-82. (PubMed:1646080)
  9. Matzuk MM et al. (1995) Different phenotypes for mice deficient in either activins or activin receptor type II [see comments] Nature, 374:356-60. (PubMed:7885474)
  10. Oh SP et al. (2002) Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning. Genes Dev, 16:2749-54. (PubMed:12414726)
  11. Song J et al. (1999) The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice. Dev Biol, 213:157-69. (PubMed:10452853)
  12. Wreford NG et al. (2001) Analysis of the testicular phenotype of the follicle-stimulating hormone beta-subunit knockout and the activin type II receptor knockout mice by stereological analysis. Endocrinology, 142:2916-20. (PubMed:11416011)
  13. Xia Y et al. (2007) Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem, 282:18129-40. (PubMed:17472960)
  14. Xu J et al. (1995) Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem, 270:6308-13. (PubMed:7890768)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory