GO Annotations Graph

• Symbol: Acvr2a
• Name: activin receptor IIA
• ID: MGI:102806

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0048185	activin binding	ISO	J:164563
Molecular Function	GO:0048185	activin binding	ISO	J:155856
Molecular Function	GO:0048185	activin binding	IBA	J:265628
Molecular Function	GO:0048185	activin binding	IPI	J:11226
Molecular Function	GO:0017002	activin receptor activity	ISO	J:164563
Molecular Function	GO:0017002	activin receptor activity	IBA	J:265628
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0098821	BMP receptor activity	ISO	J:164563
Molecular Function	GO:0098821	BMP receptor activity	IMP	J:229306
Molecular Function	GO:0015026	coreceptor activity	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	IMP	J:79880
Molecular Function	GO:0019838	growth factor binding	IPI	J:70668
Molecular Function	GO:0034711	inhibin binding	IPI	J:116370
Molecular Function	GO:0034711	inhibin binding	ISO	J:155856
Molecular Function	GO:0019209	kinase activator activity	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0030165	PDZ domain binding	IPI	J:108339
Molecular Function	GO:0005515	protein binding	IPI	J:108339
Molecular Function	GO:0005515	protein binding	IPI	J:108339
Molecular Function	GO:0005515	protein binding	IPI	J:245705
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0043621	protein self-association	IPI	J:32794
Molecular Function	GO:0004674	protein serine/threonine kinase activity	ISO	J:164563
Molecular Function	GO:0004674	protein serine/threonine kinase activity	TAS	Reactome:R-MMU-2470487
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72247
Molecular Function	GO:0004675	transmembrane receptor protein serine/threonine kinase activity	IEA	J:72245
Cellular Component	GO:0048179	activin receptor complex	IBA	J:265628
Cellular Component	GO:0009986	cell surface	IDA	J:108339
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0034673	inhibin-betaglycan-ActRII complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:72247
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-1225898
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2470487
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-2470495
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0032924	activin receptor signaling pathway	IBA	J:265628
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:114533
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:57262
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:114533
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:229306
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:164563
Biological Process	GO:0030509	BMP signaling pathway	IMP	J:123381
Biological Process	GO:0030509	BMP signaling pathway	ISO	J:123381
Biological Process	GO:0071773	cellular response to BMP stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	IBA	J:265628
Biological Process	GO:0007368	determination of left/right symmetry	IGI	J:114533
Biological Process	GO:0048706	embryonic skeletal system development	IMP	J:23924
Biological Process	GO:0001702	gastrulation with mouth forming second	IGI	J:57262
Biological Process	GO:0008584	male gonad development	IMP	J:23924
Biological Process	GO:0007498	mesoderm development	IGI	J:57262
Biological Process	GO:0042475	odontogenesis of dentin-containing tooth	IGI	J:104362
Biological Process	GO:0043084	penile erection	IMP	J:115447
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0032927	positive regulation of activin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0030501	positive regulation of bone mineralization	ISO	J:164563
Biological Process	GO:0045648	positive regulation of erythrocyte differentiation	ISO	J:164563
Biological Process	GO:0046881	positive regulation of follicle-stimulating hormone secretion	ISO	J:155856
Biological Process	GO:0045669	positive regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	ISO	J:164563
Biological Process	GO:0001934	positive regulation of protein phosphorylation	ISO	J:123381
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IBA	J:265628
Biological Process	GO:0050999	regulation of nitric-oxide synthase activity	IMP	J:115447
Biological Process	GO:0009966	regulation of signal transduction	IDA	J:127541
Biological Process	GO:0060011	Sertoli cell proliferation	IMP	J:71932
Biological Process	GO:0042713	sperm ejaculation	IMP	J:115447
Biological Process	GO:0007283	spermatogenesis	IGI	J:108808
Biological Process	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	IEA	J:72247