Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II distal enhancer sequence-specific DNA binding activity; and histone deacetylase binding activity. Involved in several processes, including camera-type eye development; nervous system development; and regulation of transcription, DNA-templated. Localizes to the nucleus. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3).