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Gene Ontology Classifications
sine oculis-related homeobox 3

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Six3. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Abe Y et al. (2009) EYA4, deleted in a case with middle interhemispheric variant of holoprosencephaly, interacts with SIX3 both physically and functionally. Hum Mutat, 30:E946-55. (PubMed:19606496)
  2. Appolloni I et al. (2008) Six3 controls the neural progenitor status in the murine CNS. Cereb Cortex, 18:553-62. (PubMed:17576749)
  3. Carl M et al. (2002) Six3 inactivation reveals its essential role for the formation and patterning of the vertebrate eye. Development, 129:4057-63. (PubMed:12163408)
  4. Gaston-Massuet C et al. (2008) Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development. Dev Biol, 324:322-33. (PubMed:18775421)
  5. Geng X et al. (2008) Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Dev Cell, 15:236-47. (PubMed:18694563)
  6. Goudreau G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A, 99:8719-24. (PubMed:12072567)
  7. Kawakami K et al. (1996) Identification and expression of six family genes in mouse retina. FEBS Lett, 393:259-63. (PubMed:8814301)
  8. Lagutin O et al. (2001) Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos. Dev Dyn, 221:342-9. (PubMed:11458394)
  9. Lagutin OV et al. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev, 17:368-79. (PubMed:12569128)
  10. Lavado A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development, 135:441-50. (PubMed:18094027)
  11. Lavado A et al. (2011) Six3 is required for ependymal cell maturation. Development, 138:5291-300. (PubMed:22071110)
  12. Lengler J et al. (2001) Antagonistic action of Six3 and Prox1 at the gamma-crystallin promoter. Nucleic Acids Res, 29:515-26. (PubMed:11139622)
  13. Liu W et al. (2010) Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate. J Clin Invest, 120:3568-77. (PubMed:20890044)
  14. Liu W et al. (2006) Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J, 25:5383-95. (PubMed:17066077)
  15. Manavathi B et al. (2007) Repression of Six3 by a corepressor regulates rhodopsin expression. Proc Natl Acad Sci U S A, 104:13128-33. (PubMed:17666527)
  16. Purcell P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns, 6:110-8. (PubMed:16024294)
  17. Vandunk C et al. (2011) Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci, 31:6457-67. (PubMed:21525287)
  18. Zhu CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development, 129:2835-49. (PubMed:12050133)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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