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Gene Ontology Classifications
Symbol
Name
ID
Six3
sine oculis-related homeobox 3
MGI:102764

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Six3. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the sine oculis homeobox transcription factor family. The encoded protein plays a role in eye development. Mutations in this gene have been associated with holoprosencephaly type 2. [provided by RefSeq, Oct 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Goudreau G et al. (2002) Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. Proc Natl Acad Sci U S A, 99:8719-24. (PubMed:12072567)
  2. Kawakami K et al. (1996) Identification and expression of six family genes in mouse retina. FEBS Lett, 393:259-63. (PubMed:8814301)
  3. Lagutin OV et al. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev, 17:368-79. (PubMed:12569128)
  4. Lavado A et al. (2008) Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon. Development, 135:441-50. (PubMed:18094027)
  5. Liu W et al. (2006) Six3 activation of Pax6 expression is essential for mammalian lens induction and specification. EMBO J, 25:5383-95. (PubMed:17066077)
  6. Purcell P et al. (2005) Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction. Gene Expr Patterns, 6:110-8. (PubMed:16024294)
  7. Vandunk C et al. (2011) Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci, 31:6457-67. (PubMed:21525287)
  8. Zhu CC et al. (2002) Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development, 129:2835-49. (PubMed:12050133)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory