Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and transcription coactivator activity. Involved in several processes, including camera-type eye development; nervous system development; and regulation of transcription, DNA-templated. Localizes to nucleus. Is expressed in several structures, including embryo ectoderm; limb; nervous system; and sensory organ. Used to study holoprosencephaly 2. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Orthologous to human SIX3 (SIX homeobox 3).