Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Myh11. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 29, 2006. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Myh11
  • participates in the following biological processes:
    • smooth muscle contraction ^[1]
  • is located in the following cellular components:
    • muscle myosin complex ^{[1, 3]}
    • myosin complex ^[4]
    • smooth muscle contractile fiber ^[1]
    • stress fiber ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Myh11
  • participates in the following biological processes:
    • metabolic process ^[3]
    • smooth muscle contraction ^{[2, 3]}
  • performs the following molecular functions:
    • motor activity ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Myh11:
  • participates in the following biological processes:
    • cardiac muscle fiber development
    • elastic fiber assembly
  • performs the following molecular functions:
    • structural constituent of muscle

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Summary text based on GO annotations supported by structural data

• Myh11 encodes a protein or proteins that contain the following InterPro domains: IQ motif, EF-hand binding site, Myosin head, motor domain, Myosin tail, Myosin, N-terminal, SH3-like, indicating that the gene product:
  • performs the following molecular functions:
    • ATP binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Myh11 indicates that it:
  • performs the following molecular functions:
    • actin binding
    • ATP binding
    • calmodulin binding
    • nucleotide binding
  • is located in the following cellular components:
    • cytoplasm
    • myosin filament

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References

1. Babu GJ et al. (2001) Loss of SM-B myosin affects muscle shortening velocity and maximal force development. Nat Cell Biol, 3:1025-9. (PubMed:11715025)
2. Karagiannis P et al. (2003) The smooth muscle myosin seven amino acid heavy chain insert's kinetic role in the crossbridge cycle for mouse bladder. J Physiol, 547:463-73. (PubMed:12562924)
3. Morano I et al. (2000) Smooth-muscle contraction without smooth-muscle myosin. Nat Cell Biol, 2:371-5. (PubMed:10854329)
4. Suzuki T et al. (1996) Preferential differentiation of P19 mouse embryonal carcinoma cells into smooth muscle cells. Use of retinoic acid and antisense against the central nervous system-specific POU transcription factor Brn-2. Circ Res, 78:395-404. (PubMed:8593698)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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