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Gene Ontology Classifications
distal-less homeobox 5

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dlx5. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Cho YD et al. (2010) The canonical BMP signaling pathway plays a crucial part in stimulation of dentin sialophosphoprotein expression by BMP-2. J Biol Chem, 285:36369-76. (PubMed:20843790)
  2. Eisenstat DD et al. (1999) DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation. J Comp Neurol, 414:217-37. (PubMed:10516593)
  3. Kim YJ et al. (2004) Bone morphogenetic protein-2-induced alkaline phosphatase expression is stimulated by Dlx5 and repressed by Msx2. J Biol Chem, 279:50773-80. (PubMed:15383550)
  4. Levi G et al. (2006) Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation. Mech Dev, 123:3-16. (PubMed:16330189)
  5. Liu JK et al. (1997) Dlx genes encode DNA-binding proteins that are expressed in an overlapping and sequential pattern during basal ganglia differentiation. Dev Dyn, 210:498-512. (PubMed:9415433)
  6. Lo Iacono N et al. (2008) Regulation of Dlx5 and Dlx6 gene expression by p63 is involved in EEC and SHFM congenital limb defects. Development, 135:1377-88. (PubMed:18326838)
  7. Long JE et al. (2003) DLX5 regulates development of peripheral and central components of the olfactory system. J Neurosci, 23:568-78. (PubMed:12533617)
  8. Masuda Y et al. (2001) Dlxin-1, a novel protein that binds Dlx5 and regulates its transcriptional function. J Biol Chem, 276:5331-8. (PubMed:11084035)
  9. Merlo GR et al. (2002) Mouse model of split hand/foot malformation type I. Genesis, 33:97-101. (PubMed:12112878)
  10. Merlo GR et al. (2002) The Dlx5 homeobox gene is essential for vestibular morphogenesis in the mouse embryo through a BMP4-mediated pathway. Dev Biol, 248:157-69. (PubMed:12142028)
  11. Robledo RF et al. (2006) Dlx5 and Dlx6 homeobox genes are required for specification of the mammalian vestibular apparatus. Genesis, 44:425-37. (PubMed:16900517)
  12. Ruest LB et al. (2004) Endothelin-A receptor-dependent and -independent signaling pathways in establishing mandibular identity. Development, 131:4413-23. (PubMed:15306564)
  13. Suzuki K et al. (2008) Abnormal urethra formation in mouse models of Split-hand/split-foot malformation type 1 and type 4. Eur J Hum Genet, 16:36-44. (PubMed:17878916)
  14. Verzi MP et al. (2007) The transcription factor MEF2C is required for craniofacial development. Dev Cell, 12:645-52. (PubMed:17420000)
  15. Wissmuller S et al. (2006) The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors. Nucleic Acids Res, 34:1735-44. (PubMed:16582099)
  16. Zaghetto AA et al. (2007) Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J Neurosci, 27:9757-68. (PubMed:17804636)
  17. Zhu H et al. (2009) Dlx5 Is a cell autonomous regulator of chondrocyte hypertrophy in mice and functionally substitutes for Dlx6 during endochondral ossification. PLoS One, 4:e8097. (PubMed:19956613)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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