Automated description from the Alliance of Genome Resources
Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in several processes, including animal organ development; face morphogenesis; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm and nuclear chromatin. Used to study split hand-foot malformation 1. Human ortholog(s) of this gene implicated in split hand-foot malformation 1 with sensorineural hearing loss. Orthologous to human DLX5 (distal-less homeobox 5).