YS

Inbr (Nctr) 84. Mottled yellow, pseudoagouti,black, piebald, depending on genotype. A^vy/a, or a/a,s. Origin: Jackson Laboratory to Chase in 1942. Crossed to get mice with a B/b and ss genotype to develop a strain designated Y_z57 . Chase to Inst. of Cancer Research 1959 at F38-39. In 1962 outcrossed to an N3 male from a (C3H/HeJxC57BL/6)xC57BL/6 cross. A^vy/a mice were backcrossed to the YS strain to N35. To Nctr in 1972, then caesarian derived and fostered on C3Hf.

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Characteristics

Strain has impared glucose tolerance on which the impairment of glucose tolerance due to obesity of A^vy/a mice is superimposed. High level of serum-glutamyltranspeptidase activity. Pseudoagouti phenotype in about 16% of A^vy/a mice. Hepatoma incidence in males at 12-16 months: 11% in A^y/a, 3% in a/a. Large testes weight (1/8) (Shire and Bartke, 1972). Maint. by Nctr.

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Shire J. G. M. and Bartke A. (1972) Strain differences in testicular weight and spermatogenesis with special reference to C57BL/10J and DBA/2J mice. J. Endocrinol. 55, 163-171.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK