of Mice: STS
Inbr (A) 100. Albino: c.
Origin: Muhlbock, from albino mice from
the Hyg. Inst. Zurich in 1955.
In contrast with five other strains, STS is resistant to mammary tumour
induction by hypophysial isografts (van der Gugten
et al 1985
). No mammary tumours but lung tumours in both sexes; closely
related to LIS/A and LTS/A. Leukosis 8% (Hilgers
and Galesloot, 1973
). High preference for sweet tasting substances
(saccharin, sucrose, dulcin and acesulfame, averaged) (3/26) (Lush
). Carries an incomplete proviral genome of endogenous mammary
tumour virus (MMTV) on the Y chromosome (c.f. 4/10) (Nishikawa et al 1991
). Higher proliferative response in
the mixed lymphocyte culture than BALB/c when tested with cells from eleven
other mouse strains with 10 MHC types (Holan
et al, 1996
J. and Galesloot J. (1973) Genetic control of MuLV-gs expression in crosses
between high and low leukemia incidence strains. Int. J. Cancer
Lipoldova M., and Demant P. (1996) Identical genetic-control of MLC reactivity
to different MHC incompatibilities, independent of production of and response
to IL-2. Immunogenet. 44, 27-35.
Lush I.M. (1988) The genetics
of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet.
Res. 53, 95-99.
R., Okumoto M., Iwai M., Iwai Y., Takamori Y., Imai S., and Hilgers J.
(1991) Incomplete proviral genome of mouse mammary tumour virus is present
on chromosome Y of NIH Swiss and some genetically related mouse strains.
Lab. Anim. 25, 4-8.
van der Gugten
A. A., Ropcke G., van Nie R., and Hilgers J. (1985) Mouse strain (STS/A)
resistant to mammary tumor induction by hypophysial isografts. Cancer
Res. 45, 3448-3453.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,