of Mice: MSM
Inbr. 20. White-bellied agouti Aw,b,c.
Origin: Wild mice trapped in Mishima City, Shizuoka Prefecture, Japan
and inbred in 1979 by Moriwaki. Has not been crossed with laboratory mice.
Previously called M.MOL-MSM. Resistant to the development of lymphoma,
due to at least two loci in crosses involving strain SL/Kh (Pataer et al, 1996
). Fibroblast-like cells from the brains
of these mice immortalise in tissue culture in a similar way to those
of other strains (Yuasa et al, 1996
F1 hybrids treated with N-methyl-N-nitrosourea (MNU) develop squamous
cell carcinomas of the forestomach with about 20% and 15% having mutations
and p53, respectively (Masui
et al, 1997
Tezuka N., Nakanishi H., Inada K. I., Miyashita N., and Tatematsu M. (1997)
Induction of invasive squamous cell carcinomas in the forestomach of (C3H
x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis
of the H-ras and p53 genes. Cancer Lett. 111,
A., Kamoto T., Lu L. M., Yamada Y., and Hiai H. (1996) Two dominant host-resistance
genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer
Res. 56, 3716-3720.
Abe E., Oshimura M., and Namba M. (1996) Immortalization of cells from
brains derived from a strain (MSM/MSfB6C3F1) of wild mouse. Acta Medica
Okayama 50, 319-324.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,