Inbred Strains
of Mice: MA
Inbr (J): 132. Albino. Genet.
c. Origin: Marsh's strain 3. Started
from a pair of mice from the Lathrop-Loeb colony (1903-1915). 32 generations
of cousin mating by Marsh, to W.S.Murray who started b x s (
Murray
1963).
Characteristics
Primary lung tumours 37% in males, 42% in females. Lymphatic leukaemia
1% in males and breeding females, zero in virgin females. Mammary tumours
zero (
Hoag, 1963). Low gross tumour incidence
(22/22) (
Storer, 1966). Polydipsia-polyuria
(
Bernstein, 1966), which may be associated
with cysts pressing on posterior lobe of pituitary (
Russell and Meier, 1966). Life-span intermediate in both
sexes (7/22 = 459 days in males, 12/22 = 585 days in females) (
Storer,
1966).
High metabolic rate (3/18) (Storer, 1967). High
plasma cholinesterase activity in females (4/22) but low in males (18/22)
(Angel et al., 1967., 1967). Low liver
arylsulphatase activity (11/12) (Daniel, 1976).
Only strain out of 29 tested that carries the mannosephosphate isomerase
Mpi 1a allele (Nichols et al., 1973., 1973).
Small spinal cord (23/25) (Roderick et al.,
1973., 1973). Large kidney/body weight ratio (4/21) (Schlager,
1968). Large hippocampus (2/9) (Wimer et
al., 1969., 1969). Fusion between left part of median lobe and left
lateral lobe of liver is common (Bunker, 1959).
Resistant to X-irradiation (2/27 in J substrain, 7/27 in My substrain)
(Roderick, 1963). Resistant to pulmonary hyaline-membrane
formation (1/10) and long survival in 90% oxygen (3/10) (Lieberman and Kellog, 1967).
Highly susceptible to the mammary tumour virus, which is not normally carried
by the strain (Murray and Little, 1967).
Angel C.
R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability
of plasma cholinesterase activity in inbred mouse strains. Science
156, 529-530.
Bernstein S.
E. (1966) Physiological characteristics, in Biology of the Laboratory
Mouse, 2nd. ed. (Green E. L., ed), pp. 337-350. McGraw-Hill, New
York.
Bunker L. E. (1959)
Hepatic fusion, a new gene in linkage group I of the mouse. J. Hered.
50, 40-44.
Daniel W. L. (1976)
Genetics of murine liver and kidney arylsulfatase B. Genetics
82, 477-491.
Hoag W. G. (1963) Spontaneous
cancer in mice. Ann. NY Acad. Sci. 108, 805-831.
Lieberman
J. and Kellog F. (1967) Hyaline-membrane formation and pulmonary plasminogen-activator
activity in various strains of mice. Pediatrics 39, 75-81.
Murray
W. S. and Little C. C. (1967) Genetic studies of carcinogenesis in mice.
J. Natl. Cancer Inst. 38, 639-656.
Murray W. S. (1963)
MA/My strain of the Marsh albino mouse. J. Natl. Cancer Inst.
30, 605-610.
Nichols
E. A., Chapman V. M., and Ruddle F. H. (1973) Polymorphism and linkage
for mannosephosphate isomerase in Mus musculus. Biochem. Genet.
8, 47-53.
Roderick
T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic
and phenotypic variation in weight of brain and spinal cord between inbred
strains of mice. Brain Res. 64, 345-353.
Roderick T. H.
(1963) The response of twenty-seven inbred strains of mice to daily doses
of whole-body X-irradiation. Radiation Res. 20, 631-639.
Russell
E. S. and Meier H. (1966) Constitutional diseases, in Biology of the
Laboratory Mouse, 2nd. ed. (Green E. L., ed), pp. 571-587. McGraw-Hill,
New York.
Schlager G. (1968)
Kidney weight in mice: strain differences and genetic determination. J.
Hered. 59, 171-174.
Storer J. B. (1966)
Longevity and gross pathology at death in 22 inbred strains of mice. J.
Gerontol. 21, 404-409.
Storer J. B. (1967)
Relation of lifespan to brain weight, body weight and metabolic rate among
inbred mouse strains. Exp. Gerontol. 2, 173-182.
Wimer R.
E., Wimer C. C., and Roderick T. H. (1969) Genetic variability in forebrain
structures between inbred strains of mice. Brain Res. 16,
257-264.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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