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Inbred Strains of Mice: MA

MA

Inbr (J): 132. Albino. Genet. c. Origin: Marsh's strain 3. Started from a pair of mice from the Lathrop-Loeb colony (1903-1915). 32 generations of cousin mating by Marsh, to W.S.Murray who started b x s (Murray 1963).


Characteristics

Primary lung tumours 37% in males, 42% in females. Lymphatic leukaemia 1% in males and breeding females, zero in virgin females. Mammary tumours zero (Hoag, 1963). Low gross tumour incidence (22/22) (Storer, 1966). Polydipsia-polyuria (Bernstein, 1966), which may be associated with cysts pressing on posterior lobe of pituitary (Russell and Meier, 1966). Life-span intermediate in both sexes (7/22 = 459 days in males, 12/22 = 585 days in females) (Storer, 1966). \par

High metabolic rate (3/18) (Storer, 1967). High plasma cholinesterase activity in females (4/22) but low in males (18/22) (Angel et al., 1967., 1967). Low liver arylsulphatase activity (11/12) (Daniel, 1976). Only strain out of 29 tested that carries the mannosephosphate isomerase Mpi 1a allele (Nichols et al., 1973., 1973). \par

Small spinal cord (23/25) (Roderick et al., 1973., 1973). Large kidney/body weight ratio (4/21) (Schlager, 1968). Large hippocampus (2/9) (Wimer et al., 1969., 1969). Fusion between left part of median lobe and left lateral lobe of liver is common (Bunker, 1959). \par

Resistant to X-irradiation (2/27 in J substrain, 7/27 in My substrain) (Roderick, 1963). Resistant to pulmonary hyaline-membrane formation (1/10) and long survival in 90% oxygen (3/10) (Lieberman and Kellog, 1967). \par

Highly susceptible to the mammary tumour virus, which is not normally carried by the strain (Murray and Little, 1967).


Angel C. R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability of plasma cholinesterase activity in inbred mouse strains. Science 156, 529-530. \par

Bernstein S. E. (1966) Physiological characteristics, in Biology of the Laboratory Mouse, 2nd. ed. (Green E. L., ed), pp. 337-350. McGraw-Hill, New York. \par

Bunker L. E. (1959) Hepatic fusion, a new gene in linkage group I of the mouse. J. Hered. 50, 40-44. \par

Daniel W. L. (1976) Genetics of murine liver and kidney arylsulfatase B. Genetics 82, 477-491. \par

Hoag W. G. (1963) Spontaneous cancer in mice. Ann. NY Acad. Sci. 108, 805-831. \par

Lieberman J. and Kellog F. (1967) Hyaline-membrane formation and pulmonary plasminogen-activator activity in various strains of mice. Pediatrics 39, 75-81. \par

Murray W. S. and Little C. C. (1967) Genetic studies of carcinogenesis in mice. J. Natl. Cancer Inst. 38, 639-656. \par

Murray W. S. (1963) MA/My strain of the Marsh albino mouse. J. Natl. Cancer Inst. 30, 605-610. \par

Nichols E. A., Chapman V. M., and Ruddle F. H. (1973) Polymorphism and linkage for mannosephosphate isomerase in Mus musculus. Biochem. Genet. 8, 47-53. \par

Roderick T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice. Brain Res. 64, 345-353. \par

Roderick T. H. (1963) The response of twenty-seven inbred strains of mice to daily doses of whole-body X-irradiation. Radiation Res. 20, 631-639. \par

Russell E. S. and Meier H. (1966) Constitutional diseases, in Biology of the Laboratory Mouse, 2nd. ed. (Green E. L., ed), pp. 571-587. McGraw-Hill, New York. \par

Schlager G. (1968) Kidney weight in mice: strain differences and genetic determination. J. Hered. 59, 171-174. \par

Storer J. B. (1966) Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21, 404-409. \par

Storer J. B. (1967) Relation of lifespan to brain weight, body weight and metabolic rate among inbred mouse strains. Exp. Gerontol. 2, 173-182. \par

Wimer R. E., Wimer C. C., and Roderick T. H. (1969) Genetic variability in forebrain structures between inbred strains of mice. Brain Res. 16, 257-264. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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last database update
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