Inbred Strains
of Mice: IF
Inbr: F70 (A). Black and tan. Genet:
at
. Origin: G. Bonser (Leeds) 1932-1936 by selection for formation of a
`wart' after tar application.
Characteristics
Now more susceptible than five other strains (including BALB/c and CBA)
to tar, methylcholanthrene and 3,4-benzpyrene. No spontaneous mammary
tumours (
Bonser, 1938). Susceptible to induction
of brain tumours by
N-ethyl-
N-nitrosourea (
Searle and Jones, 1972). High incidence of spontaneous
pseudopregnancy. Maint. by A.
Bonser G. M. (1938)
The hereditary factor in induced skin tumours in mice: establishment of
a strain specially sensitive to carcinogenic agents applied to the skin.
J. Pathol. Bacteriol. 46, 581-602.
Searle
C. E. and Jones E. L. (1972) Tumours of the nervous system in mice treated
neonatally with N-ethyl-N-nitrosourea. Nature 240, 559-560.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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