HR/De

Inbr: F78 +. Pink-eyed dilute strain carrying hairless mutation. Genet: p, hr with forced heterozygosity. Inbred by Deringer from hr stock received from Carnochan in 1948.

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Characteristics

Haemangioendotheliomas 19-33% (Heston, 1963). Skin papillomas in 3-9% of hairless animals at 18-22 weeks (Murphy, 1966). High incidence of haemangioendotheliomas (54-76%) in mice treated with 4-0- tolylazo-Otoluidine (Heston, 1963). Sensitive to chloroform toxicity (cf. 4/9) (Deringer et al., 1953., 1953). Type B reticulum-cell neoplasms at 20 weeks 12% (haired) and 8% (hairless) (Dunn and Deringer, 1968).

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Deringer M. K., Dunn T. B., and Heston W. E. (1953) Results of exposure of strain C3H mice to chloroform. Proc. Soc. Exp. Biol. Med. 83, 474-479.

Dunn T. B. and Deringer M. K. (1968) Reticulum cell neoplasm, type B, or `Hodgkin's-like lesion' of the mouse. J. Natl. Cancer Inst. 40, 771-821.

Heston W. E. (1963) Genetics of neoplasia, in Methodology in mammalian genetics (Burdette W. J., ed), pp. 247-268. Holden-Day, San Francisco.

Murphy E. D. (1966) Characteristic tumors, in Biology of the laboratory mouse, 2nd. ed. (Green E. L., ed), pp. 521-562. McGraw-Hill, New York.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK