of Mice: GRS
Inbr (A) 101. Albino a,c.
Origin:Formerly called GR/A. Muhlbock
1965 from outbred mice obtained from Grumbach in Zurich.
Breeding females have a high incidence of mammary tumours which are highly
hormone-responsive. Carries a mammary tumour agent different from MTI,
transmitted by milk and gametes, which is not eliminated by foster nursing.
Hormone-dependent tumours are also produced in GRS x RIII F1
hybrids (Muhlbock, 1965; van Nie and Thung,
1965; Brcand and Daehnfeldt, 1973
High incidence of hepatomas in mice treated with normal horse serum or
horse-anti-mouse antilymphocyte serum (Den Engelese
et al., 1976
., 1976). Leukosis 11% (Hilgers
and Galesloot, 1973
). Susceptibility to mammary tumour induction with
progesterone and oestrone in ovariectomised mice may be due to a single
gene, although linkage with eighteen marker loci could not be established
(van Nie and Hilgers, 1976
). Resistant to
the development of uterine tumours following treatment with DMBA at 4-weeks
of age (cf 3/6) (Tsubura et al, 1993
P. and Daehnfeldt J. L. (1973) Enzyme patterns of glucose catabolism in
hormone-dependent and independent mammary tumours of GR mice. Eur.
J. Cancer 9, 763-770.
L., Misdorp W., and Emmelot P. (1976) Hepatomas in GRS/A male mice treated
with horse serum or horse anti-mouse antilymphocyte serum. Eur. J.
Cancer 12, 101-106.
J. and Galesloot J. (1973) Genetic control of MuLV-gs expression in crosses
between high and low leukemia incidence strains. Int. J. Cancer
A., Senzaki H., Oyaizu T., Fujita Y., and Morii S. (1993) Strain differences
in neoplastic response to DMBA-induced uterine vascular tumors in mice.
International Journal of Oncology 2, 927-930.
van Nie R. and
Thung P. J. (1965) Responsiveness of mouse mammary tumours to pregnancy.
Eur. J. Cancer 1, 41-50.
van Nie R. and
Hilgers J. (1976) Genetic analysis of mammary tumor induction and expression
of mammary tumor virus antigen in hormone- treated ovariectomized GR mice.
J. Natl. Cancer Inst. 56, 27-32.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,