Inbred Strains
of Mice: GRS
Inbr (A) 101. Albino
a,c. Origin:Formerly called GR/A. Muhlbock
1965 from outbred mice obtained from Grumbach in Zurich.
Characteristics
Breeding females have a high incidence of mammary tumours which are highly
hormone-responsive. Carries a mammary tumour agent different from MTI,
transmitted by milk and gametes, which is not eliminated by foster nursing.
Hormone-dependent tumours are also produced in GRS x RIII F
1
hybrids (Muhlbock, 1965
; van Nie and Thung,
1965; Brcand and Daehnfeldt, 1973).
High incidence of hepatomas in mice treated with normal horse serum or
horse-anti-mouse antilymphocyte serum (
Den Engelese
et al., 1976., 1976). Leukosis 11% (
Hilgers
and Galesloot, 1973). Susceptibility to mammary tumour induction with
progesterone and oestrone in ovariectomised mice may be due to a single
gene, although linkage with eighteen marker loci could not be established
(
van Nie and Hilgers, 1976). Resistant to
the development of uterine tumours following treatment with DMBA at 4-weeks
of age (cf 3/6) (
Tsubura et al, 1993).
Brcand
P. and Daehnfeldt J. L. (1973) Enzyme patterns of glucose catabolism in
hormone-dependent and independent mammary tumours of GR mice. Eur.
J. Cancer 9, 763-770.
Den Engelese
L., Misdorp W., and Emmelot P. (1976) Hepatomas in GRS/A male mice treated
with horse serum or horse anti-mouse antilymphocyte serum. Eur. J.
Cancer 12, 101-106.
Hilgers
J. and Galesloot J. (1973) Genetic control of MuLV-gs expression in crosses
between high and low leukemia incidence strains. Int. J. Cancer
11, 780-793.
Tsubura
A., Senzaki H., Oyaizu T., Fujita Y., and Morii S. (1993) Strain differences
in neoplastic response to DMBA-induced uterine vascular tumors in mice.
International Journal of Oncology 2, 927-930.
van Nie R. and
Thung P. J. (1965) Responsiveness of mouse mammary tumours to pregnancy.
Eur. J. Cancer 1, 41-50.
van Nie R. and
Hilgers J. (1976) Genetic analysis of mammary tumor induction and expression
of mammary tumor virus antigen in hormone- treated ovariectomized GR mice.
J. Natl. Cancer Inst. 56, 27-32.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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