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Inbred Strains of Mice: CWD

CWD

Inbr (Le) 53. Non-agouti dilute: a,d,cw (curly-whiskers). Origin: cw arose in CBA/Cbi at Chester Beatty Res. Inst. To Harwell. Stock T11H from A.G.Searle to J in 1971. Crossed to B6C3Fe-a/a F1 then to DBA/2, then inbred.


Characteristics

Like AKR, HRS and C58, each of three CWD lymphomas produced infectious xenotropic murine leukemia virus related to endogenous xenotropic provirus Bxv1 (Massey et al 1990). However, in a later study the majority of CWD tumours contained recombinant viruses which lacked Bxv1 specific sequences (Massey et al, 1994).

Maint. by Le.

CXA-1 (reserved symbol)


Massey A. C., Coppola M. A., and Thomas C. Y. (1990) Origin of pathogenic determinants of recombinant murine leukemia viruses: analysis of Bxv-1-related xenotropic viruses from CWD mice. J. Virol. 64, 5491-5499. \par

Massey A. C., Lawrenz-Smith S. C., Innes D. J., and Thomas C. Y. (1994) Origins of enhancer sequences of recombinant murine leukemia viruses from spontaneous B- and T-cell lymphomas of CWD mice. Journal of Virology 68, 3773-3783. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory