Inbred Strains
of Mice: CWD
Inbr (Le) 53. Non-agouti dilute:
a,d,cw (curly-whiskers). Origin:
cw arose in CBA/Cbi at Chester Beatty Res. Inst. To Harwell. Stock
T11H from A.G.Searle to J in 1971. Crossed to B6C3Fe-
a/a F1 then
to DBA/2, then inbred.
Characteristics
Like AKR, HRS and C58, each of three CWD lymphomas produced infectious
xenotropic murine leukemia virus related to endogenous xenotropic provirus
Bxv1 (
Massey et al 1990). However,
in a later study the majority of CWD tumours contained recombinant viruses
which lacked
Bxv1 specific sequences (
Massey
et al, 1994).
Maint. by Le.
CXA-1 (reserved symbol)
Massey
A. C., Coppola M. A., and Thomas C. Y. (1990) Origin of pathogenic determinants
of recombinant murine leukemia viruses: analysis of Bxv-1-related xenotropic
viruses from CWD mice. J. Virol. 64, 5491-5499.
Massey
A. C., Lawrenz-Smith S. C., Innes D. J., and Thomas C. Y. (1994) Origins
of enhancer sequences of recombinant murine leukemia viruses from spontaneous
B- and T-cell lymphomas of CWD mice. Journal of Virology 68,
3773-3783.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK