of Mice: C57BL
Black, a. Origin: Little 1921 from the mating of female 57 with male 52
from Miss Abbie Lathrop's stock. The same cross gave rise to strains C57L
and C57BR. Female 58 mated with the same male gave rise to strain C58.
C57BL is probably the most widely used of all inbred strains, (substrain
C57BL/6 alone accounts for over 14% of occasions on which an inbred strain
is used) though in many ways it seems to be atypical of inbred strains
of laboratory mice. In contrast to 36 other standard inbred strains, it
carries a Y chromosome of Asian Mus musculus
origin (c.f. AKR
and SWR) (Tucker et al 1992
), and a LINE-1
element derived from Mus spretus
the frequency of which suggests
that up to 6.5% of the genome may be of M. spretus
origin (Rikke et al, 1995
). A probe designated B6-38
to the pseudoautosomal region of the X and Y chromosome has a characteristic
Pst I pattern of fragment sizes which is present only in the C57BL family
of strains (Kalcheva et al, 1995
It usually has a good breeding performance, depending on substrain, and
has been used as the genetic background for a large number of congenic
strains covering both polymorphic and mutant loci. Four major substrains
A, GrFa, 6 and 10 appear to be quite similar, and any differences are
consistent with what might be expected from the accumulation of new mutations
and a small ammount of residual heterozygosity, though McClive et al (1994) have found that B6 and B10 differ
at multiple loci on chrosome 4 including the microsatellite markers D4Mit69,
D4Mit71 and D4Mit72. Additional microsatellites which distinguish between
B6, B10 and C57BLKS are given by Slingsby et al (1996). The former Ks substrain differs at several loci probably
as a result of genetic contamination with a DBA substrain. This has been
re-named C57BLKS, and is listed separately. The seven major substrains
existing in 1935 are listed below.
Inbr(A) ?+142. Origin. Little to A c1932. Maint. by A.
Little to Andervont 1932. Differs from B6 and B10 at the Ce1
Origin: Little to Gruneberg 1932, to Falconer 1947. Most British substrains
derived from this stock, though 6 and 10 substrains have been imported
more recently. This substrain seems to resemble the 6 rather than the
10 substrain. Maint. by Ola
To N 1965 from Lw at F35. Maint. by N.
C57BL/Ks see C57BLKS
Inbr (J) 150. Origin: substrains 6 and 10 were separated prior to 1937.
This substrain is now probably the most widely used of all inbred strains.
Substrain 6 and 10 differ at the H9, Igh2
Maint. by J,N, Ola.
Inbr (J) 158. Origin: see C57BL/6. Maint. by J.
Inbr (J) ? +136. Little to W.L.Russell to J.P.Scott at F26 as a separate
substrain. To Snell at F35-36. Behaviour differs from C57BL/10J. Maint.
by J,N, Ola.
Carries spontaneous lipopolysaccharide mutation lps
to resemble that found in C3H/HeJ (Vogel et
Carries a spontaneous mutation, Wlds
, causing a marked slowing of axonal degeneration during Wallerian degeneration
(Tsao et al, 1994
High incidence of tail rattling (1/5) (St. John, 1973).
Short latency to attack and eat crickets (2/7) (Butler,
1973). High alcohol (ethanol) preference ratio (1/5) (McClearn,
1965). Short latency to emerge from home cage (1/7), short latency
to cross barrier in open-field (1/7), low number of stairs climbed (7/7),
low urination (6/7) and defaecation (7/7) (McClearn
et al., 1970., 1970).
High alcohol (ethanol) preference (1/4) (Fuller, 1964b), (2/18) (Rodgers,
). Achieve blood alcohol levels of 60 mg% when access to alcohol
is restricted to 60 mins. per day (Le et al, 1994
Alcohol preference may be associated with strain differences in mesolimbic
enkephalin gene expression (Ng et al, 1996
A quasi-congenic QTL introgression strain carrying a low alcohol consumption
gene from BALB/c has lower voluntary alcohol consumption than C57BL/6,
with 96% of loci in common (Vadasz et al,
). Low severity of ethanol withdrawal symptoms compared with DBA/2,
possibly associated with differences in neuroactive steriod sensitivity
(Finn et al, 1997
). Alcohol preference is
due to at least two recessive quantitative trait loci that are sex-restricted
in expression (Melo et al, 1996
Low `emotionality' (12/15), high open-field exploration (2/15) (Thompson,
1953). High spontaneous locomotor activity (8/9) (Nikulina et al 1991). Short time of immobility in a forced
swimming test (8/9) (Nikulina et al 1991).
Low shock-avoidance learning (7/9) (Bovet et
al., 1966., 1966, 1969). Low shuttle-box avoidance (5/5), high wheel
activity (1/5) (Messeri et al., 1972.,
1972). Rapid shock-avoidance learning (2/7) and slow extinction (6/7)
(Schlesinger and Wimer, 1967). High
shock-avoidance learning (1/8) (Wahlsten, 1973).
High radial-arm maze learning (1/3) (Ammassari-Teule
et al, 1993).
High locomotor activity (1/5) (Davis and King,
1967). High locomotor activity when grouped (2/6) and single (1/6)
(Davis et al., 1967., 1967). Resistant
to audiogenic seizures (11/11) (Fuller and
Sjursen, 1967). Relatively insensitive to the primary odorant isovaleric
acid (contrast seven other strains) and may provide an animal model of
specific anosmia (Wysocki et al., 1977.,
1977). Low balsa-wood gnawing activity (2/16) Fawdington and Festing (1980).
High preference for sweet tasting substances (saccharin, sucrose, dulcin
and acesulfame, averaged) (1/26) (Lush 1988).
Rejects saline at moderate concentrations (contrast 129) (Beauchamp and Fisher, 1993,
Gannon and Contreras, 1995). Feed restriction for nine days failed
to cause stereotypic cage cover climbing (contrast DBA/2) (Cabib and Bonaventira, 1997).
High open-field activity (3/15) (Thompson, 1953
High alcohol preference (6/18) (Rodgers, 1966
Good water escape learning (1/6) (Festing 1973b). Good performance in
food-seeking task (1/6) (Henderson, 1970
Insensitive to the odour of isovaleric acid (see C57BL/6). High preference
for sweet tasting substances (saccharin, sucrose, dulcin and acesulfame,
averaged) (4/26) (Lush 1988
Life-span and spontaneous disease
Mammary tumours less than 1% (Heston and Vlahakis,
1971). Lung adenomas 0-9% in LiA substrain (Mühlbock and Tengbergen,
1971). Zero incidence of mammary tumours at 2 years (cf. 3/7) (Bentvelzen et al., 1970., 1970).
Mean life-span 800 days in males and 750 days in females according to
Rowlatt et al. (1976), who also
give details of pathology in a large aging colony of C57BL/Icrf-at
mice. Hyperphalangy and polydactyly occur with a low incidence in all
C57BL strains and substrains (Dagg, 1966). Hydrocephalus
4.1% (Mori, 1968). Type B reticulum cell neoplasms
75% at about 20 weeks in HeDe substrain (Dunn
and Deringer, 1968).
Median life-span 23 months in males. Main autopsy findings include reticulum
cell sarcoma type B (29%), testes interstitial tumour (13%), thyroid follicular
adenoma (9%), unclassified lymphoreticular tumours (9%). Nine other tumour
types found. Non-neoplastic lesions include amyloid (83%), Sendai virus
pneumonia (20%), periarteritis nodosa (16%), mesenteric disease (10%).
Several other lesions noted. (Zurcher et al
., 1975). About 50%
of mice develop homogeneous immunoglobulins resembling idiopathic paraproteinaemia
in man by 24 months (Radl and Hollander, 1974).
Long life-span in males (14/17 = 645 days), but intermediate in females
(5/17 = 580 days) in SPF fostered conditions (Festing
and Blackmore, 1971
). Hydronephrosis 0.5% in females, 1.5% in males
(Taylor and Fraser, 1973
Primary lung tumours 1% in males, 3% in breeding females and zero in virgin
females. Lymphatic leukaemia less than 2%, mammary adenocarcinomas less
than 1% (Hoag, 1963
). Leukaemia 7% (Myers et al., 1970
., 1970). Rare "lipomatous" hamartomas
or choristomas have been noted (Adkison et
Susceptible to the development of atheromatous lesions on wall of aorta
after 20 weeks on a high-fat diet (Thompson, 1968; Roberts and Thompson, 1976). Develop fatty
streak-like lesions in the valve sinus region of the ascending aorta after
10-20 weeks on a diet enriched in saturated fat and cholesterol. After
a further 15 weeks fibro-fatty lesions with many of the characteristics
of human atheromatous plaques are found (Stewart-Phillips and Lough 1991). Exhibit aortic cartilaginous
metaplasia (contrast C3H) (Qiao et al, 1995).
Susceptible to diet-induced aortic fatty streak lesions which correlates
with a low level of paroxinase mRNA (contrast C3H) (Shih et al, 1996).
Develops non-insulin-dependent diabetes mellitus and hypertension when
fed a high fat-high simple carbohydrate diet, whereas A/J mice do not
(Mills et al 1993). Susceptible to the
development of atherosclerosis on a semi-synthetic high fat diet (1/9)
(Nishina et al, 1993). Blood glucose
levels and insulin insensitivity in crosses between diet-induced type
II diabetes sensitive C57BL/6 and resistant A/J are genetically independent
(Surwit et al 1991). High simple carbohydrate
diet for five months induced hyperglycemia, hyperinsulinemia and hypercholesterolemia
and non-insulin-dependent diabetes mellitus which appeared to be associated
with the metabolic characteristics of visceral fat (Rebuffe-Scrive et al, 1993). Gain more weight on high fat
diets without consuming more calories than A/J mice and develop adipocyte
hyperplasia. However, animals fed a low fat, high sucrose diet were leaner
than those fed a high-complex-carbohydrate diet. These results suggest
that genetic differences in metabolic response to fat is more important
in the development of obesity and diabetes than caloric intake (Surwit et al, 1995). Loci on chromosomes 1, 3, 5 and 11
are associated with variation in high density lipoprotein levels with
coordinate expression of cholesterol-7-alpha hydroxylase in a cross involving
atherosclerosis resistant C3H/HeJ mice (Machleder
et al, 1997). Hepatic stearoyl CoA desaturase mRNA levels significantly
elevated compared with atherosclerosis-resistant BALB/c mice, and was
reduced in mice fed a high fat diet (Park et
Congenital abnormalities 10%, including eye defects, polydactyly and otocephaly
(Kalter, 1968). Microphthalmia and anophthalmia
8-20% and hydrocephalus 1-3% (Dagg, 1966). Occular
defects appear to be due to defects in development of the lens (Robinson et al, 1993).
Develop spontaneous auditory degeneration with onset during young adulthood,
with enhanced susceptibility to acoustic injury and delayed effects of
toluene (contrast CBA/Ca) (Li, 1992, Willott et al, 1993, Li et al,
1993, Li and Borg, 1993). This is associated
with early hair cell changes including bent and fused stereocillia, bulging
of the cuticle plates, hair cell loss and swelling of affected dendrites
(Hultcrantz and Li, 1993). Carry a
single recessive gene different from that found in BALB/cBy and WB/ReJ,
causing age-related hearing loss (Willott
et al, 1995). Hearing loss is caused by degeneration of the organ
of Corti, originating in the basal, high frequency region and then proceeding
apically over time. This results in a severe sensorineural hearing loss
by 14 months of age (Walton et al, 1995).
More susceptible to noise-induced hearing loss than CBA/J (Erway et al, 1996).
Life-span above average in both sexes in conventional conditions (17/22
= 676 days in males, 18/22 = 692 days in females) (Storer,
1966). Life-span 827 _ 34 days in males, 818 _ 21 days in females
(Goodrick, 1975). Life-span 878 _ 10 days
in males and 794 _ 6 days in females (Kunstyr
and Leuenberger, 1975). Median life-span 600 days (Curtis,
1971). Gross tumour incidence 70%, maximum life-span about 1200 days
in SPF conditions (Mewissen, 1971).
Dermatitis with intense pruritis leading to self-mutilation and death,
and sometimes associated with the mite Myobia musculi appears
to be more severe in this strain than others (Csiza
and McMartin, 1976). Impaired axonal regeneration involving multiple
genetic loci (Lu et al, 1994)
Long life-span (826_29 days in males, 693_31 days in females). Overall
tumour incidence 33% in males and 31% in females, most of which is due
to lymphoma (31% in males, 29% in females) (Smith
et al., 1973
., 1973). Microphthalmia and anophthalmia 8-20% and hydrocephalus
1-3% (Dagg, 1966
). Dermatitis leading to self-mutilation
as described in C57BL/6 is also common in this substrain. Incidence may
reach 4% (Sparrow, personal communication).
Normal physiology and biochemistry
Substrain other than /6 or /10
High thyroid activity (1/5) (Van Heyningen, 1961).
Mammary gland insensitive to oestradiol and progesterone (6/7) (Singh et al., 1970., 1970). Low brain aromatic L- amino
acid decarboxylase (5/5) and low acetylcholinesterase activity (5/5) (Pryor et al., 1966., 1966). Blood catalase
has a low specific activity (6/7) (Magdon, 1962).
Low hind foot pad (9/9) but high (1/9) tail temperature (Shepard and Habas, 1967). High serum calcium (2/6) (Barrett et al., 1975., 1975). Low erythrocyte
catalase (12/18 to 17/18, depending on substrain) (Hoffman and Rechcigl, 1971). High basal level of serum prolactin
(1/6) (Sinha et al., 1975., 1975). Resistant
to dietary induction of obesity (Fenton and
Dowling, 1953). High level of alpha-fetoprotein in plasma at 7 days
(1/6) (Adinolfi et al 1990).
Low plasma cholesterol at 12 and 24 weeks (8/8) (Weibust,
). Low plasma triglyceride levels (1/11 in By and 3/11 in J substrains)
and low plasma cholesterol (2/11 in By and 4/11 in J substrains) (Jiao et al 1990
). Low serum ceruloplasmin levels in males
(24/26) but intermediate in females (Meier
and MacPike, 1968
). High blood sugar (3/12) (Nishimura,
). Low serum cholesterol (5/5) in C57BL/6-ata
(Bruell et al., 1962
., 1962). Arterial
blood has a low pH (10/10) (Bernstein, 1966
Low concentration of prostaglandin F in epididymis (6/6) (Badr,
). High liver tyrosine aminotransferase in fasted mice (3/10)
but low in C57BL/6-ob
(10/10) (Blake, 1970
Low brain L
-glutamic acid decarboxylase (GAD) (7/7) and acetylcholinesterase
activity (7/7) but high catechol-O
(2/7) (Tunnicliff et al., 1973
Low calcium uptake by the heart (4/5) (Mokler
and Iturrian, 1973
). Low sensitivity to thyrotropin (20/21) (Levy et al., 1965
., 1965). High brain sulphatide (1/5)
(Sampugna et al., 1975
., 1975). High
hepatic benz (alpha) pyrene hydroxylase activity (1/6) (Kodama and Bock, 1970
). Low hepatic delta-aminolaevulinate
dehydratase activity (8/8) (Doyle and Schimke,
). High aldehyde dehydrogenase and alcohol dehydrogenase activity
compared with DBA/2 (Sheppard et al., 1968
1968). High metabolism of 131
I with low 48 h retention (1/6)
(Chai et al., 1957
., 1957). High liver arylsulphatase
activity (1/12) (Daniel, 1976
). Low porphyrin
content of Harderian gland (16/16) (Margolis,
). Low hepatic urokinase activity (4/6 to 6/6) but high hepatic
histidine ammonia-lyase activity (1/6 to 2/6 in two substrains) (Hanford et al., 1974
., 1974). Low basal levels of kidney
catalase (4/4), superoxide dismutase (4/4) and renal glutathione reductase
(4/4) (Misra et al 1991
). Iron overload
causes inhibition of hepatic uroporphyrinogen decarboxylase and uroporphyria
in C57BL/10ScSn but not DBA/2 mice. This was not correlated with the Ah
locus in a study involving 12 mouse strains (Smith
and Francis, 1993
). Low levels of apoA-IV messenger RNA in liver compared
with 129/J (Reue et al, 1993
Low susceptibility to audiogenic seizures (6/6) (Deckard et al., 1976., 1976). Long tau DD, the endogenous
(free-running) period of the circadian pacemaker measured in constant
environmental darkness (12/12) (Schwartz
and Zimmerman 1990)
Has defective secretory group II phospholipase A2 gene (cf strains 129/Sv
and B10.RIII) (Kennedy et al, 1995).
Susceptible to severe hypercapnia with hypoxia assessed by elevated minute
ventilation rate (1/8) (Tankersley et
al, 1994). Has a rapid and shallow breathing pattern phenotype (contrast
C3H) (Tankersley et al, 1997). Susceptible
(1/7) to cerebral ischemia following bilateral carotid occlusion with
90% of mice showing typical neuological signs such as torsion of the neck
and rolling fits with selective neuronal death in the hippocampus and
caudoputamen after 20 minutes of ischemia (Yang
et al, 1997).
Low plasma testosterone level (4/5) (Hampl et
., 1971). High Na/K ratio in erythrocytes (3/9) and plasma
(2/9) (Waymouth, 1973
). Low serum ceruloplasmin
levels in males (25/26) but intermediate in females (Meier and MacPike, 1968
). Low systolic blood pressure (18/19)
(Schlager and Weibust, 1967
). Low brain
glutamic acid decarboxylase in B10.BR (10/10) and ScSn substrains (9/10)
(Gaitonde and Festing, 1976
to electroconvulsive seizures (6/6) (Deckard
et al., 1976
., 1976). Iron overload causes inhibition of hepatic uroporphyrinogen
decarboxylase and uroporphyria in C57BL/10ScSn but not DBA/2 mice. This
was not correlated with the Ah
locus in a study involving 12
mouse strains (Smith and Francis, 1993
Low proportion of basophilic cells in adenohypophysis (5/5) (Keramidas and Symeonidis, 1973).
Small kidney/body weight ratio (19/21) (Schlager,
). Large thyroid (1/5) (Mendoza et
., 1967). High total leukocyte count (2/18), low erythrocyte
count (14/18) (Russell et al., 1951
1951). Small hippocampus (9/9) (Wimer et al.,
., 1969). Accessory spleens in about 32% of mice (2/9) and low
number of Peyer's patches (7/7) (Hummel et
., 1966). Higher bone mass than A/J (Kaye
and Kusy, 1995
). Low number of haematopoetic stem cells in bone marrow
(contrast DBA/2) (Muller-Sieburg and Riblet, 1996).
Less susceptible to the development of micronuclei than BALB/c following
treatment with clastogenic base analogues and nucleosides (Sato et al, 1993). High level of spontaneous sister chromatid
exchange (4/4) (Nishi et al, 1993). A detailed
staging of these mice between gestation days 11 and 13 (Theiler's stages
18 and 21) has been published by Miyake et al, (1996). Hematopoetic stem-cell
pool 11-fold lower than in DBA/2. This is largely due to loci on chromosome
1 (Mullersieburg and Riblet, 1996). Low bone density of femur (11/11)
(Beamer et al, 1996). The timing of onset
and duration of condensation and onset of matrix formation of first arch
cartilages has been described by Miyake et al (1996a).
A detailed staging table to facilitate study of cranial skeletal development
every 2hrs. between days 11 and 13 of gestation has also been described
(Miyake et al, 1996b)
Small kidney/body weight ratio (21/21) (Schlager,
). High number of bristles on foot pad (1/8 to 3/8 in three congenic
lines) (Festing, 1976a). High yield of peritoneal exudate cells (1/5)
with a high percentage of macrophages (1/5), low percentage of lymphocytes
(5/5) and high granulocytes (1/5) (Schwartz
et al., 1975
Resistant to induction of adenocarcinomas of the colon by 1, 2-dimethylhydrazine
(cf. 2/4) (Evans et al., 1974., 1974).
Resistant to induction of pulmonary tumours (6/6) and leukaemia (5/6)
by neonatal administration of DMBA (Flaks, 1968).
Susceptible to the induction of pulmonary fibrosis by bleomycin (contrast
C3Hf/Kam) (Haston et al, 1996) and irradiation,
though the sensitivity of lung fibroblasts to irradiation in-vitro
does not correlate with in-vivo sensitivity (Dileto and Travis, 1996).
Sensitive to the development of uterine tumours following treatment with
DMBA at 4-weeks of age (cf 3/6) (Tsubura
et al, 1993). Resistant to induction of mammary tumours by urethane
(7/7) (Bentvelzen et al., 1970., 1970).
Pituitary adenoma induced in most mice by oestrogens (Heston,
1963). Resistant to skin tumour induction by methylcholanthrene (5/5)
(Andervont and Edgcomb, 1956). Susceptible
to fibrosarcoma induction by methylcholanthrene (4/15 males, 3/15 females)
Resistant to chloroform toxicity (cf. 5/9) (Deringer
et al., 1953., 1953). Resistant to induction of cleft palate by cortisone
(4/5) (Kalter, 1965).
Resistant to lethal effects of ozone (22/22) (Goldstein
et al., 1973., 1973). Resistant to colon carcinogenesis by 1,2-dimethylhydrazine
(cf. 4/7) (Evans et al., 1977., 1977).
Resistant to induction of lung tumours by urethane (6/6) (Falconer and Bloom, 1962
). Insensitive to insulin (8/9),
sensitive to histamine (2/9) (Brown, 1965
Susceptible to skin ulceration by DMBA (cf. 13/22) (Thomas et al., 1973
., 1973). Susceptible to induction of subcutaneous
tumours by 3-methylcholanthrene (3/14) (Kouri
et al., 1973
., 1973), (1/12) (Whitmire
et al., 1971
., 1971). High incidence of lymphomas after methylcholanthrene
administration by gavage (2/5) (Akamatsu and Barton, 1974). Susceptible
to toxic effects of DMBA (6/6) (Schmid et
., 1966). Pre-treatment with beta-naphthoflavone 48 hr. before
administration of N-nitrosoethylurea (ENU), once weekly for 4 weeks caused
a significant doubling in the number of lung tumor bearers (contrast 4
strains) (Anderson et al 1990
in the diet to give an intake of 85mg/kg per day resulted in 4% of animals
developing basophilic nodules by 91 weeks of age (contrast 70% in C3H/He),
but no increase in liver carcinomas (Evans
et al, 1992
). However, there was a two-fold lower level of DNA synthesis
in C57BL/6 mice relative to C3H mice after partial hepatactomy, though
partial hepatectomy is a tumour promoter in C57BL/6 but not in C3H mice
(Bennett et al, 1995
Sensitive to teratogenic effects of acetazolamide (2/6) (Green et al., 1973., 1973). Resistant to teratogenic effect
(cleft palate) by cortisone acetate (2/6) (Kalter 1981). Hepatic epoxide
hydrase activity induced by pentobarbital i.p. (cf. 4/7) (Oesch et al., 1973., 1973). Resistant to teratogenic effects
of cortisone acetate (4/4) (Dostal and Jelinek,
1973). Resistant to lethal effects of ozone (16/21) (Goldstein et al., 1973., 1973), but susceptible (cf 5/8)
to ozone-induced decreases of tracheal potential (Takahashi et al, 1995) and to airway inflammation (contrast
C3H/He) (Kleeberger et al, 1993).
Susceptible to ozone-induced lung inflammation, which is exacerbated by
vitamin A deficiency (Paquette et al, 1996).
High incidence of convulsions induced by flurothyl (1/5) (Davis and King, 1967). Susceptible to hyperbaric oxygen
(4/18) (Hill et al., 1968., 1968). Resistant
to chloroform toxicity (cf. 5/9) (Hill et al.,
1975; Deringer et al., 1953 al.,
1953). Resistant to toxic effects of isoniazid (2/10) (Taylor 1976b).
Sensitive, as judged by eosinophil response, to cortisone acetate (cf.
3/6) (Wragg and Speirs, 1952). High (89%)
ovulatory response to 3 I.U. of PMS in immature mice (2/6), but only a
56% response to 7 I.U. No facilitation by exposure to males at these doses
(Zarrow et al., 1971., 1971). High locomotor
activity after treatment with D-amphetamine (1/6) (Babbini et al., 1974., 1974). Nicotine increases learning
ability (1/9) (Bovet et al., 1966., 1966).
Resistant to colon carcinogenesis by 1,2-dimethylhydrazine (cf. 4/7) (Evans et al., 1977., 1977). Low ED50 to behavioural
effects of nicotine (3/19) (Marks et al 1989).
High self-selection of nicotine (1/6) which is inversely correlated with
sensitivity to nicotine-induced seizures (Robinson
et al, 1996).
Low bronchial reactivity (6/6) to methacholine and serotonin (Konno et al 1993). Resistant (6/8) to daunomycin-induced
nephorsis (Kimura et al 1993). Low (10/10)
neural sensitivity to pentylenetetrazol convulsions (Kosobud et al 1992). Susceptible to biliary tract injury
following oral dosing with 500 micrograms of the fungal toxin sporidesmin
(1/4) (Bhathal et al 1990). Low histamine
release from peritoneal mast cells induced by compound 48/80, a calcium
dependent histamine releaser ( c.f. 5/8) (Toda
et al 1989). Low histamine release from peritoneal mast cells induced
by Ca2+ ionophore A23187 ( c.f. 1/8, contrast BALB/c, C3H/He, DBA/2 etc.)
(Toda et al 1989). Carries gene (Tpmt)
for low levels of thiopurine methyltransferase activity, catalyzing the
S-methylation of 6-mercaptopurine and other heterocyclic and
aromaticthiol compounds (like AKR, unlike DBA/2) (Otterness and Weinshilboum 1987a,b). More sensitive to
acute toxic effects of aflatoxin B-1 than strains CBA/J or BALB/c (Almeida et al, 1996).
Airways hyporeactive to acetylcholine (c.f. 3/7) (Zhang
et al, 1995). High voluntary comsumption of morphine in two-bottle
choice situation (1/15) (Belknap et al, 1993).
Estrogen induces an increase in VLDL and LDL-cholesterol (like C57L,
contrast BALB/c and C3H) (Srivastava, 1995).
Nine-fold higher ED50 for haloperidol-induced catalepsy than DBA/2, but
this is not associated with numbers of cholinergic neurons (Dains et al, 1996). Accumulates three to five-fold lower
levels of mercury in liver and blood than DBA/2 or A.SW after 4 weeks
exposure to mercuric chloride, but higher levels in spleen following 8-12
weeks of exposure (Griem et al, 1997).
Nicotine decreases shock-avoidance learning (8/9) (Bovet
et al., 1966
., 1966). Low ED50 to behavioural effects of nicotine
(1/19) (Marks et al 1989
). Congenic line
B10.BR susceptible to induction of subcutaneous tumours by 3-methylcholanthrene
(Kouri et al., 1973
Poor immune response to low levels of bovine gamma-globulin (cf. 4/8)
(Levine and Vaz, 1970). Poor primary immune
response to bovine serum albumin (6/6) (James
and Milne, 1972). Poor primary immune response to sheep erythrocytes
(3/6 to 6/6, depending on test and dose) (Ghaffar
and James, 1973). Poor immune response to Vi antigen (cf. 3/5) (Gaines et al., 1965., 1965). Low antibody
affinity (7/7) and small quantity of antibody production (6/7) (Alpers et al., 1972., 1972). Low antibody affinity to HSA
(9/9) (Petty et al., 1972., 1972).
Serum anti-nuclear factor in 12% of animals tested (5/17) (Barnes and Tuffrey, 1967
). Good primary immune response
to bacteriophage fd (2/7) (Kolsch et al
High susceptibility to induction of amyloid by casein (1/6) (Willerson et al., 1969
., 1969). Poor immune response to
type III pneumococcal polysaccharide (4/5) (Braley
and Freeman, 1971
). Poor immune response to synthetic double- stranded
RNA (6/7) (Steinberg et al., 1971
1971). Good immune response to cholera A and B antigens (2/8) (Cerny et al., 1971
., 1971). Resistant to induction of anaphylactic
shock by ovalbumin (cf. 6/13) (Tanioka and
). Rapid rejection of about 76% of male skin isografts
by females by 25 days (1/10) (Gasser and Silvers,
). Poor immune response to GAT (random terpolymer of Glu60
) (9/10) (Dorf
et al., 1974
., 1974). Good immune response to Salmonella senftenberg
(1/5) and S. anatum
(2/5) lipopolysaccharide (Di
). Non-responder to synthetic polypeptide Glu57
(cf. 4/7) (Pinchuck
and Maurer, 1965
). High sporadic occurrence of natural haemagglutinins
to sheep red blood cells (Brooke, 1965
between `H' and `L' sheep erythrocytes (cf. 12/18) (McCarthy and Dutton, 1975
). Poor immune response to Pro-Gly-Pro-ovalbumin
(7/7) and (Pro66
(6/7) but good
immune response to (Pro-Gly-Pro)n
(1/17) (Fuchs et al., 1974
., 1974). High (2/6) PHA- stimulated lymphocyte
blastogenic response (Hellman and Fowler,
). Erythrocytes have low agglutinability (cf. 11/25) (Rubinstein et al., 1974
., 1974). High immune response to
ferritin in B6-Tla
(2/16) (Young et
., 1976). Low responder to dextran (cf. 6/10) (Blomberg et al., 1972
., 1972). Low responder to E.
ß-D-galactosidase, with "memory" developing in absence
of antibody formation (de Macario and Macario
). Precipitating and skin sensitising antibodies have slow electrophoretic
mobility (6/6) (Fahey, 1965
). Resistant to anaphylactic
shock (Treadwell, 1969
). Susceptible (1/5)
to induction of autoimmune prostatisis (contrast BALB/c) (Keetch et al, 1994
). High expression of neutral glycosphingolipid
GgOse(4)Cer in concanavalin A stimulated T lymphoblasts (cf 3/6) (Muthing,
Anti-BPO IgE monoclonal antibody produced potent systemic sensitization
sufficient for provocation of lethal shock in most aged (6 to 10 months)
mice (c.f. 3/8) (Harada et al 1991). Susceptible
to immunosuppression of contact hypersensitivity by ultraviolet B light
(cf 3/18) (Noonan and Hoffman, 1994).
High lymphocyte phytohaemagglutinin response (10/43) (Heiniger et al., 1975
., 1975). Rejection of 70% of male
skin isografts by females by 25 days (2/10) (Gasser
and Silvers, 1971
). Poor immune response to ovomucoid, but good immune
response to ovalbumin (cf. 6/12) (Vaz et al.,
., 1971). Poor immune response to DNP-keyhole limpet haemocyanin
(10/11) (Borel and Kilham, 1974
to synthetic polypeptide Glu57
(cf. 4/7) (Pinchuck and Maurer, 1965
Low antibody affinity (6/7) and small quantity of antibody produced (7/7)
(Alpers et al., 1972
1972). Discriminator between `H' and `L' sheep erythrocytes (cf. 12/18).
Also in B10.BR and B10.D2-n
and Dutton, 1975
). Low IgM antibody response to sheep red blood cells
compared with A/J (Vetvicka et al, 1993
Resistant to induction of passive cutaneous anaphylaxis (IgG1
and IgE- mediated) (12/12) (De Souza et al., 1974
1974). Erythrocytes have low agglutinability (cf. 11/25) (Rubinstein et al., 1974
., 1974). High immune response to
ferritin in B10 (4/16) and congenic lines B10.M (1/16), B10.D2 (3/I6),
B10.BR (5/16) and B10.A (6/16) (Young et al.,
., 1976). Susceptible to immunosuppression of contact hypersensitivity
by ultraviolet B light (cf 3/18) (Noonan and
). High neutrophil response to thioglycolate broth and
killed bacteria (contrast BALB/c) (Marley
et al, 1994
). Moderate susceptibility to experimental allergic encephalomyelitis
with long (1/10) duration (Lindsey, 1996
Resistant to oncogenic effects of polyoma virus given at birth (Law,
1966a). Resistant to Mycobacterium marinum (2/9) and poor
plateau harvest of M. leprae 8 months after infection (9/9) (Shepard and Habas, 1967).
Highly susceptible to infection by Salmonella typhimurium
C5 (2/7) (Plant and Glynn, 1974
Develops a slowly progressing parasitosis ("low responder") after infection
with the Cornell strain of Toxoplasma gondii
(Macario et al 1980
). Did not support sustained growth of
six strains of Leishmania mexicana mexicana
(Monroy-Ostria et al, 1994
to Leishmania major
(contrast BALB/c) (Laskay
et al, 1995, Scott et al, 1996
to L. major mexicana
, and vaccination against the parasite using
liposomes with parasite membrane antigens was effective (cf CBA/Ca but
contrast C57BL/10) (Lazama-Davila, 1997).
Susceptible to Salmonella typhimurium strain C5 (1/5) (Robson and Vas, 1972). 100-fold more resistant to Listeria
monocytogenes than A/J when measured by median lethal dose (Sadarangani et al 1980). This seems to be associated with
increased levels of gamma interferon and granulocyte-macrophage colony
stimulating factor compared with susceptible A/J mice (Iizawa et al, 1993). Resistant to Mycoplasma fermentens
(6/6) (Gabridge et al., 1972.,
1972). Resistant to Mycoplasma pulmonis infection (cf 4/16) (Cartner et al, 1996).Resistant to infection
by Mycobacterium marinum (6/6) (Yamamoto
et al 1991). Resistant to infection by liver fluke Opisthorchis
felineus (6/6) (Zelentsov, 1974). Resistant
(1/4) to infection with the helminth worm Angiostrongylus costaricennsis
(Ishii and Sano 1989). Relatively susceptible
to infection with Helicobacter felis (contrast C57BL/6) (Mohammadi et al, 1996). Susceptibile to infection by Helicobacter
felis with moderate to severe chronic active gastritis in the body
of the stomach, which increased over time (cf 4/6) (Sakagami et al, 1996). H. felis induces hypertropic
gastropathy (Fox et al, 1996).
Highly resistant to the mammary tumour virus which is thought not to
be carried by the strain (Murray and Little,
1967). Resistant to Herpes simplex virus (2/11) (Lopez,
1975). Resistant to herpes simplex virus-1 (contrast BALB/c) (Brenner et al, 1994).. Susceptible to mouse hepatitis virus
type 3 infection (cf. 5/14) (Le Prevost et al.,
1975., 1975). Develops antibodies to mouse hepatitis virus which can
be reliably detected by the complement fixation test, in contrast to five
other strains (Kagiyama et al 1991).
Low mortality in a natural epizootic of ectromelia (7/8) (Briody,
1966). High expression of RNA tumour virus group-specific antigen
in some substrains (1/8) but low in others (7/8) (Whitmire and Salerno, 1972). Resistant to development of leukaemia
on infection by Friend virus (cf. 2/11) (Dietz
and Rich, 1972). Resistant to diabetogenic effects of encephalomyocarditis
virus, but treatment with carrageenan to compromise macrophage function
makes the mice susceptible (Hirasawa et
al, 1995). Susceptible to measles virus induced encephalitis, which
correlates with a high cytotoxic T-lymphocyte response (like C3H, contrast
BALB/c) (Niewiesk et al, 1993). Resistant
to the development of tumours following inoculation with polyoma virus
(Freund et al, 1992).
Resistant (6/7) to the development of chronic Chagas' cardiomyopathy in
postacute Trypanosoma cruzi infection (Rowland
et al 1992). Resistant to infection with Trypanosoma congolense
with an initial peak of parasitemia on day 6, followed by rapid apparent
clearance in an average of 3 days (contrast BLAB/c) (Ogunremi and Tabel, 1995). Infection with larval Echinococcus
multilocularis by transportal injection of hyatid homogenate results
in a multivesiculation form of hyatid development (cf 4/9) (Nakaya et al, 1997).
Resistant to tumorigenesis induced by polymoa virus (1/9), in contrast
with C3H/Bi (Freund et al 1992). Susceptible to mouse adenovirus type
1 which causes a fatal hemorrhagic encephalomyelitis (contrast BALB/c)
(Guida et al, 1995).
Less susceptible to Streptococcus suis type 2 including the type
strain, two isolates from meningitis in pigs and two isolates from tonsils
of clinically healthy pigs (c.f. 3/5) (Kataoka
et al 1991). Resistant to carditis on infection with Lyme borreliosis
(Borrelia burgdorferi) (contrast C3H, SWR, BALB/c) (Barthold et al 1990). Thymectomized C57BL/6 mice that were
intravenously infused with monoclonal antibody to selectively deplete
CD4+ T cells are susceptible to disseminated Mycobacterium avium
infection. The increased susceptibility is comparable to that of C57BL/6-bg.
The course of such infections can be markedly restrained and in some
cases the infections can be sterilized by treatment over a 120-day period
with the antimycobacterial agent rifabutin (Furney
et al 1990). Susceptible to infection with M. avium strains
101 and 2-151, and can be used to test anti-mycobacterial agents (Furney et al, 1995). Susceptible to infection with M.
paratuberculosis (contrast C3H/HeJ) (Tanaka
et al, 1994). Resistant to infection with Yersinia enterocolitica
associate with a good interferon gamma response (contrast BALB/c) (Autenrieth et al, 1994).
Susceptible, with high amylase response to the fungus Paracoccidioides
brasiliensis (cf 6/12) (Xidieh et al,
Mouse mammary tumor proviral loci have been identified by Lee and Eicher
(1990). Resistant (1/10) to infection with
Ehrlichia risticii (Williams and
Timoney, 1994). Highly susceptible to Plasmodium berghei
with all mice developing erythrocytic infection following intravenous
injection of 50 sporozoites. The same level of infection could only be
established in BALB/c with 10,000 sporozoites (Scheller
et al, 1994). Infection with P. berghei results in low blood
parasitemia and death with neuological symptoms within 8-10 days, in contrast
with the more resistant BALB/c (Moumaris
et al (1995). Resistant to chronic weakness and inflammation following
infection with Tucon strain of coxsackie virus B1, in contrast with C57BL/10
and B10 congenic strains (Tam and Messner, 1996).
Congenic line B10.D2-n is highly susceptible to infection by Salmonella
strain C5 (3/7) (Plant and
). Resistant to Herpes simplex
virus (2/Il) (Lopez, 1975
is susceptible to
mouse hepatitis virus type 3 infection (cf. 5/14) (Le
Prevost et al., 1975
., 1975). Slow immunological expulsion of Trichinella
worms (Wakelin and Donachie
). Following administration of murine cytomegalovirus, C57BL/10
and B10.BR mice developed myocarditis after neonatal infection, but inflammation
resolved rapidly after adult infection and age-related cardiopathy was
correspondingly mild. (contrast BALB/c, C3H) (Price
et al 1991
). Resistant to infection with the helminth Mesocestoides
(contrast SJL, NIH) (Lammas et
). Resistant (2/10) to infection with Ehrlichia risticii
(Williams and Timoney, 1994
to chronic weakness and inflammation following infection with Tucon strain
of coxsackie virus B1, in contrast with C57BL/6 (Tam
and Messner, 1996
). Resistant to Mycoplasma pulmonis
(cf 4/16) (Cartner et al, 1996
with larval Echinococcus multilocularis
by transportal injection
of hyatid homogenate results in a multivesiculation form of hyatid development
(cf 4/9) (Nakaya et al, 1997
to L. major mexicana
, but vaccination against the parasite using
liposomes with parasite membrane antigens was not effective (contrast
CBA/Ca and C57BL/6) (Lazama-Davila, 1997).
Poor reproductive performance (25/25) with only 3 young weaned per litter
and 0.4 young per female/week (Festing, 1976a).
Good breeding performance, 2.2 young/female/month (6/24) (Hansen et al., 1973
Good reproductive performance (3/8). Litter size 6.2 _ 0.2, sterility 8%
(Nagasawa et al., 1973
., 1973). Large
litter size (1/6), mean 6.2 (Verley et al.,
., 1967). Good breeding performance, 2.5 young/female/month (2/24)
(Hansen et al., 1973
., 1973). Has longer
and more regular oestrus cycles than DBA/2 and C3H/HeJ (Nelson et al 1992
). Late opening of vagina and first cornification
(3/3), but early onset of cyclicity compared with C3H (Nelson et al 1990
Mice carrying the Y-chromosome from Mus musculus domesticus from
Tirano (Italy) or M.m. poschiavinus from Poschiavo (Switzerland)
fail to develop normal testes but instead develop ovaries and ovotestes.
Some hermaphroditic males become fertile, but the XY females lack normal
gonadal steroids and can not carry pregnancy to term. There is delayed
expression of IGF-I which may be responsible for the low setroid expression
(Villapandofierro et al, 1996).
Good reproductive performance (3/25) with colony output 1.4 young/female/week,
litter size 6.9 (2/25) at weaning (Festing, 1976a). Intermediate breeding
performance (12/24) (Hansen et al., 1973
High degree of genetic distinctiveness (3/27) (Taylor,
High degree of genetic distinctiveness (4/27) (Taylor,
). Recommended host for the following transplantable tumours:
mammary adenocarcinoma BW 10232 melanoma B16, myeloid leukaemia C 1498
and preputial gland carcinoma ESR586 (Kaliss, 1972).
Embryonic stem cell lines have been established (Kawase
et al, 1994).
High rate of spontaneous mutations at the agouti and W loci (1/21)
(Schlager and Dickie, 1967).
High incidence of spontaneous `deviants' (possible mutants) (2/21) (Schlager and Dickie, 1967
Origin: C57BL/6J to Biesele in 1947, then pen bred, to Kaliss in 1948.
Ks resumed inbreeding. To J 1948. Differs from C57BL/6 and C57BL/10 at
the Bgls, Bglt, cdm and H2 loci as a result of a genetic
contamination, probably with a DBA substrain at the time the colony was
pen-bred. Resembles B6 at the Lv locus (at which B6 and B10 differ).
Formerly known as C57BL/Ks but renamed in Dec. 1994. Maint. by J.
Low hepatic delta-aminolaevulinate dehydratase activity in Ks substrain
(7/8) (Doyle and Schimke, 1969). High susceptibility
to BALB/Tennant leukaemia virus in Ks substrain (3/12) (Tennant,
1965). Resistant to Herpes simplex virus (2/11) in Ks substrain
(Lopez, 1975). High retinal ganglion cell number
(22/24) (Williams et al, 1996).
M., Beck S. E., Seller M. J., Fedor T., and McLaren A. (1990) Alpha-fetoprotein
levels in different strains of mice during development. Exp. Clin.
Immunogenet. 7, 123-128.
D. L. and Sundberg J. P. (1991) "Lipomatous" hamartomas and choristomas
in inbred laboratory mice. Vet. Pathol. 28, 305-312.
R. M. A., Correa B., Xavier J. G., Mallozzi M. A. B., Gambale W., and
Paula C. R. (1996) Acute effect of aflatoxin B-1 on different inbred mouse
strains. Mycopathologia 133, 23-29.
J. H., Steward M. W., and Southill J. E. (1972) Differences in immune
elimination in inbred mice. The role of low affinity antibody. Clin.
Exp. Immunol. 12, 121-132.
Ammassari-Teule M., Hoffman H. J., and Rossi-Arnaud C. (1993)
Learning in inbred mice: strain-specific abilities across three radial
maze problems. Behav. Genet. 23, 405-412.
L. M., Jones A. B., and Kovatch R. M. (1990) Effect of pretreatment with
beta-naphthoflavone on tumorigenesis by N-nitrosoethylurea in five mouse
strains. Cancer Lett. 16, 91-94.
H. B. and Edgcomb J. H. (1956) Responses of seven inbred strains of mice
to percutaneous applications of 3-methylcholanthrene. J. Natl. Cancer
Inst. 17, 481-495.
I. B., Beer M., Bohn E., Kaufmann S. H. E., and Heesemann J. (1994) Immune
responses to Yersinia enterocolitica in susceptible BALB/c and
resistant C57BL/6 mice: An essential role for gamma interferon. Infect.
Immun. 62, 2590-2599.
M., Pong S. F., King W. T., and White C. L. (1974) Mobility of mice after
amphetamine: effects of strain aggregation and illumination. Pharmacol.
Biochem. Behav. 2, 803-809.
Badr F. M. (1975) Prostaglandin
levels in tissues of the male reproductive system in six strains of mice.
Endocrinol. 96, 540-543.
R. D. and Tuffrey M. (1967) Serum antinuclear factor and the influence
of environment in mice. Nature 214, 1136-1138.
C. P., Donati E. J., Volz J. E., and Smith E. B. (1975) Variations in
serum calcium between strains of inbred mice. Lab. Animal Sci.
S. W., Beck D. S., Hansen G. M., Terwilliger G. A., and Moody K. D. (1990)
Lyme borreliosis in selected strains and ages of laboratory mice. J.
Infect. Dis. 162, 133-138.
W. G., Donahue L. R., Rosen C. J., and Baylink D. J. (1996) Genetic-variability
in adult bone-density among inbred strains of mice. Bone 18,
G. K. and Fisher A. S. (1993) Strain differences in consumption of saline
solutions by mice. Physiol. Behav. 54, 179-184.
J. K., Crabbe J. C., Riggan J., and O'Toole L. A. (1993) Voluntary consumption
of morphine in 15 inbred mouse strains. Psychopharmacology 112,
L. M., Farnham P. J., and Drinkwater N. R. (1995) Strain-dependent differences
in DNA synthesis and gene expression in the regenerating livers of C57BL/6J
and C3H/HeJ mice. Molecular Carcinogenesis 14, 46-52.
P., Daams J. H., Hageman P., and Calafat J. (1970) Genetic transmission
of viruses that incite mammary tumors in mice. Proc. Natl. Acad. Sci.
USA 67, 377-384.
E. (1966) Physiological characteristics, in Biology of the Laboratory
Mouse, 2nd. ed. (Green E. L., ed), pp. 337-350. McGraw-Hill, New
P. S., Jordan T. W., and Mackay I. R. (1990) Mouse strain differences
in susceptibility to sporidesmin-induced biliary tract injury. Liver
Blake R. L. (1970) Regulation
of liver tyrosine amino transferase activity in inbred strains and mutant
mice. I. Strain variance in fasting enzyme levels. Int. J. Biochem.
B., Geckeler W. R., and Weigert M. (1972) Genetics of the antibody response
to Dextran in mice. Science 177, 178-180.
and Kilham L. (1974) Carrier-determined tolerance in various strains of
mice: the role of isogenic IgG in the induction of hapten specific tolerance.
Proc. Soc. Exp. Biol. Med. 145, 470-474.
Bovet-Nitti F., and Oliverio A. (1966) Effects of nicotine on avoidance
conditioning of inbred strains of mice. Psychopharmacologia 10,
H. C. and Freeman M. J. (1971) Strain differences in antibody plaque-
forming cell responses in inbred mice to pneumococcal polysaccharide.
Cell. Immunol. 2, 73-81.
G. J., Cohen N., and Moynihan J. A. (1994) Similar immune response to
nonlethal infection with herpes simplex virus-1 in sensitive (BALB/c)
and resistant (C57BL/6) strains of mice. Cell. Immunol. 157,
Briody B. A. (1966)
The natural history of mouse pox. National Cancer Institute Monograph
Brooke M. S. (1965)
Natural haemogglutinins in mice: their occurrence and properties. Immunol.
Brown A. M. (1965) Pharmacogenetics
of the mouse. Lab. Anim. Care 15, 111-118.
J. H., Daroczy A. F., and Hellerstein H. K. (1962) Strain and sex differences
in serum cholesterol levels in mice. Science 135, 1071-1072.
Butler K. (1973) Predatory
behaviour in laboratory mice. Strain and sex comparisons. J. Comp.
Physiol. Psychol. 85, 243-249.
and Bonaventura N. (1997) Parallel strain-dependent susceptibility to
environmentally-induced stereotypies and stress-induced behavioral sensitization
in mice. Physiol. Behav. 61, 499-506.
S. C., Simecka J. W., Briles D. E., Cassell G. H., and Lindsey J. R. (1996)
Resistance to Mycoplasmal lung-disease in mice is a complex genetic trait.
Infect. Immun. 64, 5326-5331.
McAlack R. F., Sajid M. A., and Friedman H. (1971) Genetic differences
in the immunocyte response of mice to separate determinants on one bacterial
antigen. Nature New Biol. 230, 247-248.
Chai C. K.,
Amin A., and Reineke E. P. (1957) Thyroidal iodine metabolism in inbred
and F1 hybrid mice. Am. J. Physiol. 188, 499-502.
K. and McMartin D. N. (1976) Apparent acaridal dermatitis in a C57BL/6
Nya mouse colony. Lab. Animal Sci. 26, 781-787.
Curtis H. J. (1971)
Genetic factors in aging. Adv. Genet. 16, 305-324.
Dagg C. P. (1966) Teratogenesis,
in Biology of the laboratory mouse, 2nd. ed. (Green E. L., ed),
pp. 309-328. McGraw-Hill, New York.
Hitzemann B., and Hitzemann R. (1996) Genetics, neuroleptic response and
the organization of cholinergic neurons in the mouse striatum. J.
Pharmacol. Exp. Therapeut. 279, 1430-1438.
Daniel W. L. (1976)
Genetics of murine liver and kidney arylsulfatase B. Genetics
M. and King W. T. (1967) Pharmacogenetic factor in the convulsive responses
of mice to flurothyl. Experientia 23, 214-215.
De Souza C. M.,
Maia L. C. S., and Vaz N. M. (1974) Susceptibility to cutaneous anaphylaxis
in inbred strains of mice. J. Immunol. 112, 1369-1372.
B. S., Lieff B., Schlesinger K., and DeFries J. C. (1976) Developmental
patterns of seizure susceptibility in inbred strains of mice. Devel.
Psychobiol. 9, 17.
M. K., Dunn T. B., and Heston W. E. (1953) Results of exposure of strain
C3H mice to chloroform. Proc. Soc. Exp. Biol. Med. 83,
Di Pauli R. (1972) Genetics
of the immune response. I. Differences in the specificity of antibodies
to lipopolysaccharides among different strains of mice. J. Immunol.
and Rick M. A. (1972) Effect of host strain and H-2 type on spontaneous
regression of murine leukemia virus. Int. J. Cancer 10,
C. L. and Travis E. L. (1996) Fibroblast radiosensitivity in-vitro and
lung fibrosis in-vivo -comparison between a fibrosis-prone and fibrosis-resistant
mouse strain. Radiation Res. 146, 61-67.
Dorf M. E.,
Dunham E. K., Johnson J. P., and Benacerraf B. (1974) Genetic control
of the immune response: the effect of non-H-2 linked genes on antibody
production. J. Immunol. 112, 1329-1336.
M. and Jelinek R. (1973) Sensitivity of embryos and intraspecies differences
in mice in response to prenatal administration of corticoids. Teratology
and Schimke R. T. (1969) The genetic and developmental regulation of hepatic
-aminolaevulinate dehydratase in mice. J. Biol. Chem. 244,
Dunn T. B.
and Deringer M. K. (1968) Reticulum cell neoplasm, type B, or `Hodgkin's-like
lesion' of the mouse. J. Natl. Cancer Inst. 40, 771-821.
C., Shiau Y. W., Davis R. R., and Krieg E. F. (1996) Genetics of age-related
hearing-loss in mice .3. Susceptibility of inbred and F1-hybrid strains
to noise-induced hearing-loss. Hearing Research 93, 181-187.
T., Hauschka T. S., and Mittelman A. (1974) Differential susceptibility
of four mouse strains to induction of multiple large-bowel neoplasms by
1,2,-dimethylhydrazine. J. Natl. Cancer Inst. 52, 999-1000.
T., Shows T. B., Sproul E. E., Paolini N. S., Mittelman A., and Hauschka
T. S. (1977) Genetics of colon carcinogenesis in mice treated with 1,
2-dimethylhydrazine. Cancer Res. 37, 134-136.
G., Collins M. A., Lake B. G., and Butler W. H. (1992) The histology and
development of hepatic nodules and carcinoma in C3H/He and C57BL/6 mice
following chronic phenobarbitone administration. Toxicologic Pathology
Fahey J. L. (1965) Differences
in the electrophoretic mobility of antibody from inbred strains of mice.
J. Immunol. 94, 819-823.
D. S. and Bloom J. L. (1962) A genetic study of induced lung tumours in
mice. Brit. J. Cancer 16, 665-685.
P. F. and Dowling M. T. (1953) Studies on obesity. I. Nutritional obesity
in mice. J. Nutrit. 49, 319-331.
M. F. W. and Blackmore D. K. (1971) Life span of specified-pathogen-free
(MRC category 4) mice and rats. Lab. Anim. 5, 179-192.
Finn D. A.,
Roberts A. J., Lotrich F., and Gallaher E. J. (1997) Genetic differences
in behavioral sensitivity to a neuroactive steroid. J. Pharmacol.
Exp. Therapeut. 280, 820-828.
Flaks A. (1968) The
susceptibility of various strains of neonatal mice to the carcinogenic
effects of 9, 1 0-dimethyl- 1, 2-benzanthracene. Eur. J. Cancer
Fox J. G., Li
X., Cahill R. J., Andrutis K., Rustgi A. K., Odze R., and Wang T. C. (1996)
Hypertrophic gastropathy in Helicobacter felis-infected wild-type
C57BL/6 mice and p53 hemizygous transgenic mice. Gastroenterology
Mozes E., Maoz A., and Sela M. (1974) Thymus independence of a collagen-like
synthetic polypeptide and of collagen, and the need for thymus and bone
marrow-cell cooperation in the immune response to gelatin. J. Exp.
Med. 139, 148-158.
J. L. and Sjursen F. H. (1967) Audiogenic seizures in eleven mouse strains.
J. Hered. 58, 135-140.
S. K., Roberts A. D., and Orme I. M. (1990) Effect of rifabutin on disseminated
Mycobacterium avium infections in thymectomized, CD4 T-cell-deficient
mice. Antimicrobial Agents & Chemotherapy 34, 1629-1632.
S. K., Skinner P. S., Farrer J., and Orme I. M. (1995) Activities of rifabutin,
clarithromycin, and ethambutol against two virulent strains of Mycobacterium
avium in a mouse model. Antimicrobial Agents & Chemotherapy 39,
M. G., Abrams G. D., and Murphy W. H. (1972) Lethal toxicity of Mycoplasma
fermentens in mice. J. Infect. Dis. 125, 153-160.
S., Currie J. A., and Tully J. G. (1965) Factors affecting formation of
incomplete Vi antibody in mice. J. Bacteriol. 90, 635-642.
M. K. and Festing M. F. W. (1976) Brain glutamic acid decarboxylase and
open field activity in ten inbred strains of mice. Brain Res.
K. S. and Contreras R. J. (1995) Sodium intake linked to amiloride-sensitive
gustatory transduction in C57BL/6J and 129/J mice. Physiol. Behav.
D. L. and Silvers W. K. (1971) Genetic basis of male skin rejection in
mice. Transplant. 12, 412-414.
A. and James K. (1973) The effect of antilymphocyte antibody on the humoral
immune response in different strains of mice. Immunol. 24,
B. D., Lai L. Y., Ross S. R., and Cuzzi-Spada R. (1973) Susceptibility
of inbred mouse strains to ozone. Arch. Environ. Health 27,
Goodrick C. L.
(1975) Lifespan and the inheritance of longevity of inbred mice. J.
Gerontol. 30, 257-263.
C., Azar C. A., and Maren T. H. (1973) Strain differences in susceptibility
to the teratogenic effect of acetazolamide in mice. Teratology
Scholz E., Turfeld M., Zander D., Wiesner U., Dunemann L., and Gleichmann
E. (1997) Strain differences in tissue concentrations of mercury in inbred
mice treated with mercuric chloride. Toxicol. Appl. Pharmacol.
D., Fejer G., Pirofski L. A., and Brosnan C. F. (1995) Mouse adenovirus
type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but
not BALB/c mice. Journal of Virology 69, 7674-7681.
Ivanyi P., and Starka L. (1971) Testosterone and testosterone binding
in murine plasma. Steroidologia 2, 113-120.
W. C., Nep R. L., and Arfin S. M. (1974) Genetic variation in histidine
ammonia-lyase activity in the mouse. Biochem. Biophys. Res. Comm.
C. T., Judge F. J., and Whitney R. A. (1973) Catalog of NIH rodents.
National Institutes of Health. DHEW publication (NIH) 74-606, Bethesda.
M., Nagata M., Takeuchi M., Ohara T., Makino S., and Watanabe A. (1991)
Age-dependent difference in susceptibility to IgE antibody- and IgG1 antibody-mediated
passive anaphylactic shock in the mouse. Immunological Investigations
C. K., Amos C. I., King T. M., and Travis E. L. (1996) Inheritance of
susceptibility to bleomycin-induced pulmonary fibrosis in the mouse. Cancer
Res. 56, 2596-2601.
H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of
the phytohaemagglutinin responsiveness of lymphocytes and its relationship
to leukemogenesis. Cancer Res. 35, 825-831.
A. and Fowler A. K. (1972) Studies of the blastogenic response of murine
lymphocyte. III. Specific viral transformation. Proc. Soc. Exp. Biol.
Med. 141, 106-109.
D. (1970) Genetic influences on the behaviour of mice can be obscured
by laboratory rearing. J. Comp. Physiol. Psychol. 72,
W. E. and Vlahakis G. (1971) Mammary tumours, plaques and hyperplastic
alveolar nodules in various combinations of mouse inbred strains and the
different lines of the mammary tumour virus. Int. J. Cancer 7,
Heston W. E. (1963)
Genetics of neoplasia, in Methodology in mammalian genetics (Burdette
W. J., ed), pp. 247-268. Holden-Day, San Francisco.
Hill G. B.,
Osterhout S., and O'Fallon W. M. (1968) Variation in response to hyperbaric
oxygen among inbred strains of mice. Proc. Soc. Exp. Biol. Med.
Hill R. N.,
Clemens T. L., Liu D. K., and Vesell E. S. (1975) Genetic control of chloroform
toxicity in mice. Science 190, 159-161.
K., Ogiso Y., Takeda M., Lee M. J., Itagaki S., and Doi K. (1995) Protective
effects of macrophage-derived interferon against encephalomyocarditis
virus-induced diabetes mellitus in mice. Lab. Animal Sci. 45,
Hoag W. G. (1963) Spontaneous
cancer in mice. Ann. NY Acad. Sci. 108, 805-831.
H. A. and Rechcigl M. Jr. (1971) Erythrocyte catalase in inbred mice.
Enzyme 12, 219-225.
M. and Li H. S. (1993) Inner ear morphology in CBA/Ca and C57BL/6J mice
in relationship to noise, age and phenotype. European Archives of
Oto-Rhino-Laryngology 250, 257-264.
K. P., Richardson F. L., and Fekete E. (1966) Anatomy, in Biology
of the Laboratory Mouse, 2nd. ed. (Green E. L., ed), pp. 247-307.
McGraw-Hill, New York.
Y., Wagner R. D., and Czuprynski C. J. (1993) Analysis of cytokine mRNA
expression in Listeria-resistant C57BL/6 and Listeria-susceptible A/J
mice during Listeria monocytogenes infection. Infect. Immun.
I. and Sano M. (1989) Strain-dependent differences in susceptibility of
mice to experimental Angiostrongylus costaricennsis infection. J.
Helminthology 63, 302-306.
and Milne I. (1972) The effect of anti-lymphocytic antibody on the humoral
immune response in different strains of mice. I. The response to bovine
serum albumin. Immunol. 23, 897-909.
Jiao S., Cole
T. G., Kitchens R., Pfleger B., and Schonfeld G. (1990) Genetic heterogeneity
of lipoproteins in inbred strains of mice: analysis by gel-permeation
chromatography. Metabolism 39, 155-160.
N., Takakura A., Koyoma K., Terada E., and Sakuria Y. (1991) Detection
of mouse hepatitis virtus antibody by protein A-ELISA in 6 prevalent inbred
strains or outbred stocks of mice. Lab. Anim. 25, 106-109.
I. D., Matsuda Y., Plass C., and Chapman V. M. (1995) Isolation and characterization
of a pseudoautosomal region-specific genetic-marker in C57BL/6 mice using
genomic representational difference analysis. Proceedings of the National
Academy of Sciences of the United States of America 92, 12352-12356.
Kalter H. (1965) Interplay
of intrinsic and extrinsic factors, in Teratology (Wilson J.
G. and Warkany J., eds) University of Chicago Press, Chicago.
Kalter H. (1968) Sporadic
congenital malformations of newborn inbred mice. Teratology 1,
Y., Haritani M., Mori M., Kishima M., Sugimoto C., Nakazawa M., and Yamamoto
K. (1991) Experimental infections of mice and pigs with Streptococcus
suis type 2. J. Vet. Med. Sci. 53, 1043-1049.
E., Suemori H., Takahashi N., Okazaki K., Hashimoto K., and Nakatsuji
N. (1994) Strain difference in establishment of mouse embryonic stem (ES)
cell lines. International Journal of Developmental Biology 38,
Kaye M. and
Kusy P. (1995) Genetic lineage, bone mass, and physical activity in mice.
Bone 17, 131-135.
D. W., Humphrey P., and Ratliff T. L. (1994) Development of a mouse model
for nonbacterial prostatitis. Journal of Urology 152,
B. P., Payette P., Mudgett J., Vadas P., Pruzanski W., Kwan M., Tang C.,
Rancourt D. E., and Cromlish W. A. (1995) A natural disruption of the
secretory group II phospholipase A2 gene in inbred mouse strains. J.
Biol. Chem. 270, 22378-22385.
G. D. and Symeonidis A. (1973) Characteristic microscopic differences
in the adenohypophysis of high and low mammary tumour strains of mice.
Pathol. Eur. 8, 35-36.
M., Takahasi H., Ohtake T., Sato T., Hishida A., Nishimura M., and Honda
N. (1993) Interstrain differences in murine daunomycin-induced nephorsis.
Nephron 63, 193-198.
S. R., Levitt R. C., and Zhang L. Y. (1993) Susceptibility to ozone-induced
inflammation. I. Genetic control of the response to subacute exposure.
American Journal of Physiology - Lung Cellular and Molecular Physiology
Y. and Bock F. G. (1970) Benz  pyrene-metabolizing enzyme activity of
livers of various strains of mice. Cancer Res. 30, 1846-1849.
Adachi M., Matsuura T., Sunouchi K., Hoshino H., Okazawa A., Kobayashi
H., and Takahashi T. (1993) Bronchial reactivity to methacholine and serotonin
in six inbred mouse strains. [Japanese]. Japanese Journal of Allergology
A. E., Cross S. J., and Crabbe J. C. (1992) Neural sensitivity to pentylenetetrazol
convulsions in inbred and selectively bred mice. Brain Res. 592,
E., Salerno R. A., and Whitmire C. E. (1973) Relationships between arylhydrocarbon
hydroxylase inducibility and sensitivity to chemically induced subcutaneous
sarcomas in various strains of mice. J. Natl. Cancer Inst. 50,
I. and Leuenberger H. G. W. (1975) Gerontological data on C57BL/6 mice.
I. Sex differences in survival curves. J. Gerontol. 30,
D. A., Mitchell L. A., and Wakelin D. (1990) Genetic influences upon eosinophilia
and resistance in mice infected with Mesocestoides corti. Parasitology
T., Diefenbach A., Rollinghoff M., and Solbach V. (1995) Early parasite
containment is decisive for resistance to Leishmania major infection.
Eur. J. Immunol. 25, 2220-2227.
Law L. W. (1966a) Studies
of thymic function with emphasis on the role of the thymus in oncogenesis.
Cancer Res. 26, 551-574.
Le Prevost C.,
Virelizier J. L., and Dupuy J. M. (1975) Immunopathology of mouse hepatitis
virus type 3 infection. III. Clinical and virologic observation of a persistent
viral infection. J. Immunol. 115, 640-643.
Le A. D., Ko J.,
Chow S., and Quan B. (1994) Alcohol consumption by C57BL/6, BALB/c, and
DBA/2 mice in a limited access paradigm. Pharmacol. Biochem. Behav.
Lee B. K. and
Eicher E. M. (1990) Segregation patterns of endogenous mouse mammary tumor
viruses in five recombinant inbred strain sets [published erratum appears
in J Virol 1991 Mar;65(3):1666]. J. Virol. 64, 4568-4572.
B. B. and Vaz N. M. (1970) Effect of combinations of inbred strain, antigen
and antigen dose on immune responsiveness and reagin production in the
mouse. Int. Arch. Allergy 39, 156-171.
Levy R. P.,
McGuire W. L., Shaw R. K., and Bartsch G. E. (1965) Effect of species
differences of mice on the bioassay of thyrotropin. Endocrinol.
Li H. S. and Borg
E. (1993) Auditory degeneration after acoustic trauma in two genotypes
of mice. Hearing Research 68, 19-27.
Li H. S. (1992) Genetic influences
on susceptibility of the auditory system to aging and environmental factors.
Scandinavian Audiology, Supplement 21, 1-39.
Lindsey J. W. (1996)
Characteristics of initial and reinduced experimental autoimmune encephalomyelitis.
Immunogenet. 44, 292-297.
Lopez C. (1975) Genetics
of natural resistance to herpes virus infections in mice. Nature
Lu X., Skamene
E., and Richardson P. M. (1994) Studies of axonal regeneration in C57BL/6J
and A/J mice. Brain Res. 652, 174-176.
Lush I.M. (1988) The genetics
of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet.
Res. 53, 95-99.
A. J. L., Stahl W., and Miller R. M. (1980) Lymphocyte subpopulations
and function in chronic murine toxaplasmosis. II. Cyclic immunosuppression
in genetic-low-responder mice. Cell. Immunol. 56, 235-239.
D., Ivandic B., Welch C., Castellani L., Reue K., and Lusis A. J. (1997)
Complex genetic control of HDL levels in mice in response to an atherogenic
diet - Coordinate regulation of HDL levels and bile acid metabolism. J.
Clin. Invest. 99, 1406-1419.
Magdon E. von (1962)
Untersuchungen der katalaseaktivitat des Blutes vershiedener Mausestamme.
Z. Versuchstierk. 1, 173-178.
Margolis F. L.
(1971) Regulation of porphyrin biosynthesis in the Harderian gland of
inbred mouse strains. Arch. Biochem. Biophys. 145, 373-381.
J., Stitzel J. A., and Collins A. C. (1989) Genetic influences on nicotine
responses. Pharmacol. Biochem. Behav. 33, 667-678.
S. B., Hadley C. L., and Wakelin D. (1994) Effect of genetic variation
on induced neutrophilia in mice. Infect. Immun. 62, 4304-4309.
M. M. and Dutton R. W. (1975) The humoral response of mouse spleen cells
to two types of sheep erythrocytes. J. Immunol. 115, 1316-1321.
G. E., Wilson J. R., and Meredith W. (1970) The use of isogenic and heterogenic
mouse stocks in behavioral research, in Contribution to behavior genetic
analysis. The mouse as a prototype (Lindzey G. and Thiessen D. D.,
eds), pp. 3-32. Appleton-Century-Crofts, New York.
McClearn G. E.
(1965) Genotype and mouse behavior, in Genetics Today (Geerts
J. J., ed) Proc. XI Int. Genetics Congress, The Hague, Sept. 1993, .
P. J., Huang D., and Morahan G. (1994) C57BL/6 and C57BL/10 inbred mouse
strains differ at multiple loci on chromosome 4. Immunogenet.
and MacPike A. D. (1968) Levels and heritability of serum ceruloplasmin
activity in inbred strains of mice. Proc. Soc. Exp. Biol. Med.
Melo J. A.,
Shendure J., Pociask K., and Silver L. M. (1996) Identification of sex-specific
quantitative trait loci controlling alcohol preference in C57BL/6 mice.
Nature Genet. 13, 147-153.
L. A., Hamburg M., and Fuld H. (1967) Differences in thyroid activity
in several inbred strains of mice. Anat. Rec. 158, 275-280.
P., Oliverio A., and Bovet D. (1972) Relations between avoidance and activity.
A diallel study in mice. Behav. Biol. 7, 733-742.
Mewissen D. J.
(1971) Natural tumor incidence in a population of mice as a reference
index. Fed. Proc. 30, 311.
Kuhn C. M., Feinglos M. N., and Surwit R. (1993) Hypertension in CB57BL/6J
mouse model of non-insulin-dependent diabetes mellitus. Am. J. Physiol.
Rodriguez R. E., North S. L., and Kasprzak K. S. (1991) Nickel-induced
renal lipid peroxidation in different strains of mice: concurrence with
nickel effect on antioxidant defense systems [published erratum appears
in Toxicol Lett 1992 60:239]. Toxicol. Lett. 58, 121-133.
T., Cameron A. M., and Hall B. K. (1996a) Detailed staging of inbred C57BL/6
mice between Theiler's  stages 18 and 21 (11-13 days of gestation)
based on craniofacial development. Journal of Craniofacial Genetics
and Developmental Biology 16, 1-31.
T., Cameron A. M., and Hall B. K. (1996b) Stage-specific onset of condensation
and matrix deposition for Meckel's and other first arch cartilages in
inbred C57BL/6 mice. Journal of Craniofacial Genetics and Developmental
Biology 16, 32-47.
M., Redline R., Nedrud J., and Czinn S. (1996) Role of the host in pathogenesis
of Helicobacter-associated gastritis: H. felis Infection of inbred
and congenic mouse strains. Infect. Immun. 64, 238-245.
C. M. and Iturrian W. B. (1973) Strain differences in subcellular calcium
distribution in striated muscle of the mouse. Proc. Soc. Exp. Biol.
Med. 142, 919-923.
Monroy-Ostria A., Fuentes-Fraga I., Garcia-Flores C., and Favila-Castillo
L. (1994) Infection of BALB/c, C57Bl/6 mice and F1 hybrid CB6F1 mice with
strains of Leishmania mexicana isolated from Mexican patients
with localized or diffuse cutaneous leishmaniasis. Archives of Medical
Research 25, 401-406.
Mori A. (1968) Hereditary
hydrocephalus in C57BL mouse. Brain and Nerve 20, 695-700.
M., Sestier C., Miltgen F., Halbreich A., Gentilini M., and Sabolovic
D. (1995) Effect of fatty acid treatment in cerebral malaria-susceptible
and nonsusceptible strains of mice. Journal of Parasitology 81,
W. S. and Little C. C. (1967) Genetic studies of carcinogenesis in mice.
J. Natl. Cancer Inst. 38, 639-656.
Muthing J. (1997)
Neutral glycosphingolipids and gangliosides from spleen T lymphoblasts
of genetically different inbred mouse strains. Glycoconjugate Journal
D., Meier H., and Huebner R. J. (1970) Prevalence of murine C-type RNA
virus group specific antigen in inbred strains of mice. Life Sci.
H., Miyamoto M., and Fujimoto M. (1973) Reproductivity in inbred strains
of mice and project for their efficient production. Exp. Animals (Japan)
K., Nakao M., and Ito A. (1997) Echinococcus multilocularis:
Mouse strain difference in hydatid development. J. Helminthology
J. F., Karelus K., Felicio L. S., and Johnson T. E. (1990) Genetic influences
on the timing of puberty in mice. Biol. Reprod. 42, 649-655.
J. F., Karelus K., Felicio L. S., and Johnson T. E. (1992) Genetic influences
on oestrous cyclicity in mice: evidence that cycle length and frequency
are differentially regulated. J. Reprod. Fertil. 94, 261-268.
Ng G. Y. K., Odowd
B. F., and George S. R. (1996) Genotypic differences in mesolimbic enkephalin
gene-expression in DBA/2J and C57BL/6J inbred mice. Eur. J. Pharmacol.
S., Brinckmann U., Bankamp B., Sirak S., Liebert U. G., and Ter Meulen
V. (1993) Susceptibility to measles virus-induced encephalitis in mice
correlates with impaired antigen presentation to cytotoxic T lymphocytes.
Journal of Virology 67, 75-81.
E. M., Skrinskaya J. A., and Popova N. K. (1991) Role of genotype and
dopamine receptors in behaviour of inbred mice in a forced swimming test.
Psychopharmacology 105, 525-529.
Hasegawa M. M., and Inui N. (1993) Genetic variations in baseline and
ultraviolet light-induced sister chromatid exchanges in peritoneal lymphocytes
among different mouse strains. Mutation Research - Fundamental and
Molecular Mechanisms of Mutagenesis 286, 145-154.
(1969) Breeding of mice strains for diabetes mellitus. Exp. Animals
(Japan) 18, 147-157.
P. M., Wang J., Toyofuku W., Kuypers F. A., Ishida B. Y., and Paigen B.
(1993) Atherosclerosis and plasma and liver lipids in nine inbred strains
of mice. Lipids 28, 599-605.
F. P. and Hoffman H. A. (1994) Susceptibility to immunosuppression by
ultraviolet B radiation in the mouse. Immunogenet. 39,
Morris N., and Daly J. W. (1973) Genetic expression of the induction of
epoxide hydrase and aryl hydrocarbon hydroxylase activities in the mouse
by phenobarbital or 3-methylcholanthrene. Molec. Pharmacol. 9,
O. and Tabel H. (1995) Genetics of resistance to Trypanosoma congolense
in inbred mice: Efficiency of apparent clearance of parasites correlates
with long-term survival. Journal of Parasitology 81, 876-881.
D. M. and Weinshilboum R. M. (1987a) Mouse thiopurine methyltransferase
pharmacogenetics: biochemical studies and recombinant inbred strains.
J. Pharmacol. Exp. Therapeut. 240, 180-186.
N. C., Zhang L. Y., Ellis W. A., Scott A. L., and Kleeberger S. R. (1996)
Vitamin A deficiency enhances ozone-induced lung injury. American
Journal of Physiology - Lung Cellular and Molecular Physiology 270,
Park E. I.,
Paisley E. A., Mangian H. J., Swartz D. A., Wu M. X., O'Morchoe P. J.,
Behr S. R., Visek W. J., and Kaput J. (1997) Lipid level and type alter
stearoyl CoA desaturase mRNA abundance differently in mice with distinct
susceptibilities to diet-influenced diseases. J. Nutrit. 127,
E., Steward M. W., and Soothill J. F. (1972) The heterogeneity of antibody
affinity in inbred mice and its possible immunopathologic significance.
Clin. Exp. Immunol. 12, 231-241.
P. and Maurer P. H. (1965) Antigenicity of polypeptides (poly alpha amino
acids). XVI. Genetic control of immunogenicity of synthetic polypeptides
in mice. J. Exp. Med. 122, 673-679.
and Glynn A. A. (1974) Natural resistance to Salmonella infection, delayed
hypersensitivity and Ir genes in different strains of mice. Nature
Eddy K. S., Papadimitriou J. M., Faulkner D. L., and Shellam G. R. (1991)
Genetic determination of cytomegalovirus-induced and age-related cardiopathy
in inbred mice. Characterization of infiltrating cells. Am. J. Pathol.
T., Schlesinger K., and Calhoun W. H. (1966) Differences in brain enzymes
among five inbred strains of mice. Life Sci. 5, 2105-2111.
Qiao J. H.,
Fishbein M. C., Demer L. L., and Lusis A. J. (1995) Genetic determination
of cartilaginous metaplasia in mouse aorta. Arteriosclerosis, Thrombosis,
and Vascular Biology 15, 2265-2272.
Rebuffe-Scrive M., Surwit R., Feinglos M., Kuhn C., and Rodin
J. (1993) Regional fat distribution and metabolism in a new mouse model
(C57BL/6J) of non-insulin-dependent diabetes mellitus. Metabolism:
Clinical and Experimental 42, 1405-1409.
Reue K., PurcellHuynh
D. A., Leete T. H., Doolittle M. H., Durstenfeld A., and Lusis A. J. (1993)
Genetic variation in mouse apolipoprotein A-IV expression is determined
pre- and post-transcriptionally. J. Lipid Res. 34, 893-903.
A., Zhao Y., Daggett L. P., Reyes R., and Hardies S. C. (1995) Mus spretus
LINE-1 sequences detected in the Mus musculus inbred strain C57BL/6J using
LINE-1 DNA probes. Genetics 139, 901-906.
A. and Thompson J. S. (1976) Inbred mice and their hybrids as an animal
model for atherosclerosis research, in Atherosclerosis Drug Discovery
(Day C. E., ed), pp. 313-327. Plenum Press, New York.
M. L., Holmgren A., and Dewey M. J. (1993) Genetic control of ocular morphogenesis:
Defective lens development associated with ocular anomalies in C57BL/6
mice. Exp. Eye Res. 56, 7-16.
S. F., Marks M. J., and Collins A. C. (1996) Inbred mouse strains vary
in oral self-selection of nicotine. Psychopharmacology 124,
H. G. and Vas S. I. (1972) Resistance of mice to Salmonella typhimurium.
J. Infect. Dis. 126, 378-380.
Rodgers D. A. (1966)
Factors underlying differences in alcohol preference among inbred strains
of mice. Psychosomat. Med. 28, 498-513.
E. C., Lozykowski M. G., and McCormick T. S. (1992) Differential cardiac
histopathology in inbred mouse strains chronically infected with Trypanosoma
cruzi. Journal of Parasitology 78, 1059-1066.
C., Chesterman F. C., and Sheriff M. U. (1976) Lifespan, age changes and
tumour incidence in an ageing C57BL mouse colony. Lab. Anim.
P., Liu N., Strenn E. W., and Decary F. (1974) Electrophoretic mobility
and agglutinability of red blood cells: a `new' polymorphism in mice.
J. Exp. Med. 139, 313-322.
E. S., Neufeld E. F., and Higgins C. T. (1951) Comparison of normal blood
picture of young adults from 18 inbred strains of mice. Proc. Soc.
Exp. Biol. Med. 78, 761-766.
C., Skamene E., and Kongshaven P. A. L. (1980) Cellular basis for genetically
determined enhanced resistance of certain mouse strains to Listeriosis.
Infect. Immun. 28, 381-386.
T., Dixon M., ORourke J., Howlett R., Alderuccio F., Vella J., Shimoyama
T., and Lee A. (1996) Atrophic gastric changes in both Helicobacter
felis and Helicobacter pylori infected mice are host dependent
and separate from antral gastritis. Gut 39, 639-648.
J., Clements J., Carter T. P., and Campagnoni A. T. (1975) Comparison
of lipids in total brain tissue from five mouse genotypes. J. Neurobiol.
Sato S. I.,
Takizawa H., and Inui N. (1993) Mouse strain differences in induction
of micronuclei by base analogues and nucleosides. Mutation Research
- Mutation Research Letters 301, 45-49.
L. F., Wirtz R. A., and Azad A. F. (1994) Susceptibility of different
strains of mice to hepatic infection with Plasmodium berghei. Infect.
Immun. 62, 4844-4847.
G. and Dickie M. M. (1967) Spontaneous mutations and mutation rates in
the house mouse. Genetics 57, 319-330.
Schlager G. (1968)
Kidney weight in mice: strain differences and genetic determination. J.
Hered. 59, 171-174.
K. and Wimer R. (1967) Genotype and conditioned avoidance learning in
the mouse. J. Comp. Physiol. Psychol. 63, 139-141.
F. A., Dickey P. A., Stanco G. A., and Tarnowski G. S. (1966) Toxicity
of intraperitoneal injections of 7,1 2-dimethylbenz (a) anthracene (DMBA)
and other agents in inbred mice.# Proc. Am. Assoc. Cancer Res.
R. H., Jackson L., and Paul W. E. (1975) T-lymphocyte-enriched murine
peritoneal exudate cells. I. A reliable assay for antigen-induced T- lymphocyte
proliferation. J. Immunol. 115, 1330-1338.
W. J. and Zimmerman P. (1990) Circadian timekeeping in BALB/c and C57BL/6
inbred mouse strains. Journal of Neuroscience 11, 3685-3694.
Eaton A., Gause W. C., Zhou X. D., and Hondowicz B. (1996) Early IL-4
production does not predict susceptibility to Leishmania major.
Experimental Parasitology 84, 178-187.
C. C. and Habas J. A. (1967) Relation of infection to tissue temperature
in mice infected with Mycobacterium marinum and Mycobacterium leprae.
J. Bacteriol. 93, 790-796.
J. R., Albersheim P., and McClearn G. E. (1968) Enzyme activities and
ethanol preference in mice. Biochem. Genet. 2, 205-212.
Shih D. M.,
Gu L., Hama S., Xia Y. R., Navab M., Fogelman A. M., and Lusis A. J. (1996)
Genetic-dietary regulation of serum paraoxonase expression and its role
in atherogenesis in a mouse model. J. Clin. Invest. 97,
V., DeOme K. B., and Bern H. A. (1970) Strain differences in response
of the mouse mammary gland to hormones in vitro. J. Natl. Cancer Inst.
M., Salocks C. B., and Vanderlaan W. P. (1975) Prolactin and growth hormone
levels in different inbred strains of mice: patterns in association with
estrous cycle, time of day and perphenazine stimulation. Endocrinol.
J. H., Hogarth M. B., Simpson E., Walport M. J., and Morley B. J. (1996)
New microsatellite polymorphisms identified between C57BL-6, C57BL- 10,
and C57BL-KsJ inbred mouse strains. Immunogenet. 43, 72-75.
S., Walford R. L., and Mickey R. M. (1973) Lifespan and incidence of cancer
and other diseases in selected long-lived inbred mice and their F1 hybrids.
J. Natl. Cancer Inst. 50, 1195-1213.
G. and Francis J. E. (1993) Genetic variation of iron-induced uroporphyria
in mice. Biochem. J. 291, 29-35.
R. A. K. (1995) Increased apoB100 mRNA in inbred strains of mice by estrogen
is caused by decreased RNA editing protein mRNA. Biochemical and Biophysical
Research Communications 212, 381-387.
St. John R. D. (1973) Genetic
analysis of tail rattling in the mouse. Nature 241, 550.
A. D., Pincus T., and Talal N. (1971) The pathogenesis of autoimmunity
in New Zealand mice. III. Factors influencing the formation of anti-nucleic
acid antibodies. Immunol. 20, 523-531.
Stewart-Phillips J. L. and Lough J. (1991) Pathology of atherosclerosis
in cholesterol-fed, susceptibile mice. Atherosclerosis 90,
Storer J. B. (1966)
Longevity and gross pathology at death in 22 inbred strains of mice. J.
Gerontol. 21, 404-409.
Strong L. C. (1952)
Differences in response among mice of fifteen inbred strains to the subcutaneous
injection of methylcholanthrene. Yale J. Biol. Med. 25,
R. S., Seldin M. F., Kuhn C. M., Cochrane C., and Feinglos M. N. (1991)
Control of expression of insulin resistance and hyperglycemia by different
genetic factors in diabetic C57BL/6J mice. Diabetes 40,
R. S., Feinglos M. N., Rodin J., Sutherland A., Petro A. E., Opara E.
C., Kuhn C. M., and Rebuffe-Scrive M. (1995) Differential effects of fat
and sucrose on the development of obesity and diabetes in C57BL/6J and
A/J mice. Metabolism: Clinical and Experimental 44, 645-651.
M., Kleeberger S. R., and Croxton T. L. (1995) Genetic control of susceptibility
to ozone-induced changes in mouse tracheal electrophysiology. American
Journal of Physiology - Lung Cellular and Molecular Physiology 269,
Tam P. E. and
Messner R. P. (1996) Genetic-determinants of susceptibility to coxsackievirus
B1-induced chronic inflammatory myopathy - effects of host background
and major histocompatibility complex genes. Journal of Laboratory
and Clinical Medicine 128, 279-289.
S., Sato M., Taniguchi T., and Yokomizo Y. (1994) Histopathological and
morphometrical comparison of granulomatous lesions in BALB/c and C3H/HeJ
mice inoculated with Mycobacterium paratuberculosis. J. Comp. Pathol.
Y. and Esaki K. (1971) Strain differences in mortality of anaphylactic
shock in mice-challenging by intravenous injection. Exp. Animals (Japan)
C. G., Fitzgerald R. S., and Kleeberger S. R. (1994) Differential control
of ventilation among inbred strains of mice. American Journal of Physiology
- Regulatory Integrative and Comparative Physiology 267, R1371-R1377.
C. G., Fitzgerald R. S., Levitt R. C., Mitzner W. A., Ewart S. L., and
Kleeberger S. R. (1997) Genetic control of differential baseline breathing
pattern. J. Appl. Physiol. 82, 874-881.
D. M. and Fraser H. (1973) Hydronephrosis in inbred strains of mice with
particular reference to the BRVR strain. Lab. Anim. 7,
Taylor B. A. (1972)
Genetic relationship between inbred strains of mice. J. Hered.
Tennant J. R. (1965)
Susceptibility and resistance to viral leukemogenesis in the mouse. I.
Biological definition of the virus. J. Natl. Cancer Inst. 34,
P. E., Hutton J. J., and Taylor B. A. (1973) Genetic relationship between
aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced
skin ulceration in mice. Genetics 74, 655-659.
Thompson W. R.
(1953) The inheritance of behaviour: behavioural differences in fifteen
mouse strains. Can. J. Psychol. 7, 145-155.
Thompson J. S.
(1968) Atherosclerosis in inbred strains of mice. Anat. Res.
Toda S., Kimura
M., and Tohya K. (1989) Strain differences in histamine release from mouse
peritoneal mast cells induced by compound 48/80 or A23187. Jikken
Dobutsu - Experimental Animals 38, 135-137.
E. (1969) The inheritance of susceptibility to anaphylaxis in inbred mice
and their hybrid progenies. J. Reticuloendothel. Soc. 6,
Tsao J. W.,
Brown M. C., Carden M. J., McLean W. G., and Perry V. H. (1994) Loss of
the compound action potential: An electrophysiological, biochemical and
morphological study of early events in axonal degeneration in the C57BL/Ola
mouse. European Journal of Neuroscience 6, 516-524.
A., Senzaki H., Oyaizu T., Fujita Y., and Morii S. (1993) Strain differences
in neoplastic response to DMBA-induced uterine vascular tumors in mice.
International Journal of Oncology 2, 927-930.
P. K., Lee B. K., Lundrigan B. L., and Eicher E. M. (1992) Geographic
origin of the Y chromosomes in "old" inbred strains of mice. Mamm.
Genome 3, 254-261.
G., Wimer C. C., and Wimer R. E. (1973) Relationships between neurotransmitter
metabolism and behaviour in seven inbred strains of mice. Brain Res.
C., Fleischer A., Lafrancois J., and Mao R. F. (1996) Self-administration
of ethanol - towards the location of predisposing polygenes in quasi-congenic
animal-models. Alcohol 13, 617-620.
Van Heyningen H. E. (1961)
Differences in thyroid function of several strains of mice. Proc.
Soc. Exp. Biol. Med. 106, 37-40.
Vaz N. M., Phillips-Quagliata
J. M., Levine B. B., and Vaz E. M. (1971) H-2 linked genetic control of
immune responsiveness to ovalbumin and ovomucoid. J. Exp. Med.
F. A., Grahn D., Leslie W. P., and Hamilton K. F. (1967) Sex ratio of
mice as possible indicator of mutation rate for sex-linked lethals. J.
Hered. 58, 285-290.
V., Vonkova J., and Rihova B. (1993) Effect of age on antibody responses
in low responder C57BL/10ScSn and high responder A/J strains of mice.
Mechanisms of Ageing and Development 71, 131-141.
N., Weinblatt A. C., and Rosenstreich D. L. (1981) Inherent macrophage
defects, in Immunologic defects in laboratory animals Vol. 1
(Gershwin M. E. and Merchant B., eds), pp. 327-357. Plenum Press, New
Wahlsten D. (1973)
Contribution of the genes albinism (c) and retinal degeneration (rd) to
a strain-by-training procedure interaction in avoidance learning. Behav.
Genet. 3, 303-316.
D. and Donachie A. M. (1980) Genetic control of immunity to parasites:
adoptive transfer of immunity between inbred strains of mice characterized
by rapid and slow immune expulsion of Trichinella spiralis. Parasite
Immunol. 2, 249-260.
J. P., Frisina R. D., and Meierhans L. R. (1995) Sensorineural hearing
loss alters recovery from short-term adaptation in the C57BL/6 mouse.
Hearing Research 88, 19-26.
Waymouth C. (1973)
Erythrocyte sodium and potassium levels in normal and anaemia mice. Comp.
Biochem. Physiol. 44A, 751-766.
Weibust R. S. (1973)
Inheritance of plasma cholesterol levels in mice. Genetics 73,
C. E., Salerno R. A., Rabstein L. S., Heubner R. J., and Turner H. C.
(1971) RNA tumour-virus antigen expression in chemically induced tumours.
Virus-genome specified common antigens detected by complement fixation
in mouse tumours induced by 3-methylcholanthrene. J. Natl. Cancer
Inst. 47, 1255-1265.
C. E. and Salerno R. A. (1972) RNA tumour virus antigen and tumour induction
by various doses of 3-methylcholanthrene in various strains of mice treated
as weanlings. Cancer Res. 32, 1129-1132.
J. T., Asofsky R., and Barth W. F. (1969) Experimental murine amyloid.
IV amyloidosis and immunoglobulins. J. Immunol. 103, 741-749.
N. M. and Timoney P. J. (1994) Variation in susceptibility of ten mouse
strains to infection with a strain of Ehrlichia risticii. J. Comp.
Pathol. 110, 137-143.
R. W., Strom R. C., Rice D. S., and Goldowitz D. (1996) Genetic and environmental-control
of variation in retinal ganglion-cell number in mice. Journal of Neuroscience
J. F., Aitkin L. M., and McFadden S. L. (1993) Plasticity of auditory
cortex associated with sensorineural hearing loss in adult C57BL/6J mice.
J. Comp. Neurol. 329, 402-411.
J. F., Erway L. C., Archer J. R., and Harrison D. E. (1995) Genetics of
age-related hearing loss in mice. II. Strain differences and effects of
caloric restriction on cochlear pathology and evoked response thresholds.
Hearing Research 88, 143-155.
E., Wimer C. C., and Roderick T. H. (1969) Genetic variability in forebrain
structures between inbred strains of mice. Brain Res. 16,
E. and Speirs R. S. (1952) Strain and sex differences in response of inbred
mice to adrenal cortical hormones. Proc. Soc. Exp. Biol. Med.
C. J., Whitney G., and Tucker D. (1977) Specific anosmia in the laboratory
mouse. Behav. Genet. 7, 171-188.
C. F., Singer-Vermes L. M., Calich V. L. G., and Burger E. (1994) Plasma
amylase levels as a marker of disease severity in an isogenic murine model
of paracoccidioidomycosis. Journal of Medical and Veterinary Mycology
Y., Saito H., Setogawa T., and Tomioka H. (1991) Sex differences in host
resistance to Mycobacterium marinum infection in mice. Infect. Immun.
Yang G. M.,
Kitagawa K., Matsushita K., Mabuchi T., Yagita Y., Yanagihara T., and
Matsumoto M. (1997) C57BL/6 strain is most susceptible to cerebral ischemia
following bilateral common carotid occlusion among seven mouse strains:
Selective neuronal death in the murine transient forebrain ischemia. Brain
Res. 752, 209-218.
R., Deacon N. J., Ebringer A., and Davis D. A. L. (1976) Genetic control
of the immune response to ferritin in mice. J. Immunogenet. 3,
M. X., Christenson C. M., and Eleftheriou B. C. (1971) Strain differences
in the ovulatory response of immature mice to PMS and to the pheromonal
facilitation of PMS-induced ovulation. Biol. Reprod. 4,
G. (1974) Susceptibility of inbred mice to helminths. II. Development
of Opisthorchis felineus in A/He, CBA/Lac, CC57W/Mv, C57BL/6J, DBA/2J
and SWR/J mice [in Russian]. Med. Parazit. (Mosk.). 43,
Y., Levitt R. C., and Kleeberger S. R. (1995) Differential susceptibility
to ozone-induced airways hyperreactivity in inbred strains of mice. Experimental
Lung Research 21, 503-518.
de Macario E.
C. and Macario A. J. L. (1980) Immunosuppression associated with erythropoiesis
in genetic low responder mice. Ann. Immunol (Inst. Pasteur) 131C,
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
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