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Inbred Strains of Mice: BUB

BUB

Inbr (J) 122. Albino a,c. Origin: from albinos of unknown ancestry at Brown University, maintained by random mating until 1945. Carries no detectable endogenous ecotropic MuLV DNA sequences (Jenkins et al 1982). High serum complement activity (c.f. 8/26) (Ong et al 1989, 1992). High ED50 to behavioural effects of nicotine (19/19). Sensitive to seizures induced by nicotine (17/19) (Marks et al 1989). Carries a T-cell receptor mutation which, in association with other unknown genes, makes the strain highly susceptible to the induction of inflammatory autoimmune arthritis by type II collagen (Ortman et al, 1994, Haqqi et al, 1995).

Maintained by J.


Jenkins N. A., Copeland N. G., Taylor B. A., and Lee B. K. (1982) Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol. 43, 26-36. \par

Marks M. J., Stitzel J. A., and Collins A. C. (1989) Genetic influences on nicotine responses. Pharmacol. Biochem. Behav. 33, 667-678. \par

Ong G. L. and Mattes M. J. (1989) Mouse strains with typical mammalian levels of complement activity. J. Immunol. Methods 125, 147-158. \par

Ortman R. A., Holderbaum D., Qu X. M., Banerjee S., and Haqqi T. M. (1994) BUB/BnJ (H-2(q)) is a TCR deletion mutant mouse strain (TCR Vbetaa, KJ16- ) that is susceptible to type II collagen-induced arthritis. J. Immunol. 152, 4175-4182. \par


INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK

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last database update
04/18/2017
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The Jackson Laboratory